Probenecid CAS 57-66-9

Probenecid CAS 57-66-9

Chemical Name: Probenecid

CAS number: 57-66-9

Molecular formula: C13H19NO4S

Molecular weight: 285.36

Appearance: white crystalline powder

Effective content (%): ≥95-99


What is Probenecid?


1. Probenecid is a new type of highly effective penicillins and cephalosporin antibiotics. Specially used for penicillins, cephalosporin antibiotics synergist, can enhance the efficacy of cephalosporins, penicillins 8-10 times.

2. In addition, this product can also competitively inhibit the secretion of weak organic acids (such as penicillin, cephalosporin) in the renal tubules, thereby increasing the blood concentration of these antibiotics and prolonging their action time.

3. This product is easily absorbed by oral administration, and the plasma protein binding rate is as high as 85% to 90%. Adults take 1g each time, the plasma concentration reaches the peak within 2 to 4 hours, and the half-life is 6 to 12 hours. Probenecid is rapidly metabolized in the liver, and the main metabolite is probenecid acetoglucuronic acid. Metabolites are mainly excreted in urine. This product has no anti-inflammatory and analgesic effects, so it is ineffective against acute gout.

Probenecid Usage

1. Treatment of gout, hyperuricemia, 1.25-2.5g per horse, cow, sheep, pig 0.5g, chicken 40mg, cat, dog 60mg, twice daily.

2. To enhance penicillin, cephalosporins efficacy and duration of action, according to 1 part probenecid (calculated as pure product): 3.5 parts of penicillin, cephalosporin ratio compatibility.

Probenecid Instructions

After the product is dissolved by adding water (the ratio of dissolution can be determined according to the actual situation), It is soluble in dilute sodium hydroxide solution and almost insoluble in dilute acid.

Probenecid Packaging, storage, transportation and expiration date

The product can be packaged in 1kg, 5kg, 10kg, 20kg according to the customer’s needs, or packaged according to the user’s needs; it can be stored in dark, dry and sealed place and the valid period is 24 months.


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