tween 85 cas 9005-70-3

Tween 85 Details

Chemical Name:Tween 85

CAS No.: 9005-70-3

Molecular Formula: CH4

Molecular Weight:16.04246

MolecularStructure:Tween 85 CAS 9005-70-3

Appearance:Yellow to amber oily liquid


Tween 85 Typical Properties

Appearance Yellow to amber oily liquid
Acid Value(KOH mg/g) ≤2.0
Saponification Value(KOH mg/g) 83-98
Hydroxyl Value(KOH mg/g) 40-60
Water(%) ≤3.0%

Tween 85 Usage

  1. Emulsifying Agent: Tween 85, with CAS number 9005-70-3, is commonly used as an emulsifying agent. It is part of the Tween series of surfactants and is particularly effective in forming stable oil-in-water emulsions.
  2. Pharmaceutical Formulations: This compound is utilized in pharmaceutical formulations. Tween 85 can be included in certain drug formulations to enhance solubility and bioavailability, especially for poorly water-soluble drugs.
  3. Food and Beverage Industry: Tween 85 may be employed in the food and beverage industry. It is used in certain formulations to improve the texture and stability of products, such as baked goods and emulsified beverages.
  4. Cosmetic Products: In the cosmetic industry, Tween 85 is used in certain formulations. It may be present in skincare and personal care products to aid in the emulsification of ingredients and enhance product stability.

Tween 85 Packaging and Shipping

Packing: 25kg/drum,50 kg/drum, 200kg/drum

Tween 85 Storage

Stored in ventilated place away from acids, oxidants and food

tween range of products

Specification Tween-20 Tween-40 Tween-60 Tween-80
CAS 9005-64-5 9005-66-7 9005-67-8 9005-65-6
Appearance(25℃) Amber coloured viscous liquid Slightly yellow waxy solid Slightly yellow waxy solid Amber viscous oil
Hydroxyl value(mgKOH/g) 90~110 85~100 80~105 65~82
Saponification value(mgKOH/g) 40~50 40~55 40~55 43~55
Acid value(mgKOH/g) ≤2.0 ≤2.0 ≤2.0 ≤2.0
Moisture(%) ≤3 ≤3 ≤3 ≤3
HLB value 16.5 15.5 14.5 15
Specific Gravity 1.08~1.13 1.05~1.10 1.05~1.10 1.06~1.09


Specifications Performance and Specifications
T-20 1、It is easily soluble in water, methanol, ethanol, isopropanol and other solvents, insoluble in movable and mineral oil, with emulsification, diffusion, solubilisation, stabilisation and other properties.
2、This product is harmless to human body, no irritation, in the food industry is mainly used for cake, ice cream, shortening and other production.
3、In other aspects, it can be used as emulsifier of mineral oil, solvent of dyestuff, emulsifier of cosmetic, stabiliser of foam, emulsifier, diffuser and stabiliser of pharmaceuticals and auxiliary agent of photo emulsion.
T-40 1, easily soluble in water, methanol, ethanol, isopropanol and other solvents, insoluble in dynamic, mineral oil, used as o/w-type emulsifier, solubiliser, stabiliser, diffusion agent, antistatic agent, lubricant.
T-60 1, soluble in water, methanol, ethanol, isopropanol and other solvents, insoluble in dynamic, mineral oil, has excellent emulsifying properties, both wetting, foaming, diffusion and other effects.
2、Used as o/w type emulsifier, dispersant, stabiliser, used in food, medicine, cosmetics, water-based paint manufacturing.
3、Used as softener and antistatic agent in textile industry, it is the softener of polyacrylonitrile spinning oil component and fibre post-processing, which can make the fibre eliminate static electricity, improve its softness and give the fibre good dyeing performance.
T-80 1, soluble in water, methanol, ethanol, insoluble in mineral oil, used as emulsifier, dispersant, wetting agent, solubiliser, stabilizer, used in medicine, cosmetics, food and other industries.
2, in the production of polyurethane foam used as a stabilizer, foaming agent; in synthetic fibres can be used as an antistatic agent, is the intermediate of chemical fibre oils; in the production of photographic materials used as a wetting agent and dispersant in the film; in the process of waterproofing of fabrics by emulsified silicone oil, with good results, also used in nylon and viscose cords as an oil agent and water-soluble emulsifier, often mixed with S-80.
3、It is used as emulsifier, anti-waxing agent, thick oil wetting, drag reducing agent, near-well zone treatment agent in oil field; it is used as lubricating coolant for precision machine tool modulation.

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  1. What is the role of polysorbate (Tween) in formulation?
  Polysorbate (PS) is a class of amphiphilic, nonionic surfactant family, the most widely used surfactant in biopharmaceutical formulations, which prevents denaturation of proteins in the melting process, aggregation, surface adsorption and flocculant formulations.   As a preparation used as a protein stabilizer, mainly because Tween specific biocompatibility is better, low toxicity, and can effectively stabilize the role of proteins. Even at lower concentrations, PS20 and PS80 provide adequate protein stability due to their high hydrophilic-lipophilic equilibrium values and low critical micelle concentrations.    
  1. What is the mechanism of protein stabilization by Tween?
  It is commonly believed that PS20 and PS80 stabilize proteins primarily through interfacial competition.The surface activity of PS20 and PS80 is much higher than that of typical therapeutic proteins (e.g., monoclonal antibodies), and as a result, they competitively block interfaces and inhibit adsorption of proteins to the gas-liquid interface. This property effectively prevents proteins from unfolding at the interface during manufacturing, sample handling and storage (including mixing, filtration, pumping, shaking, stirring and freezing/thawing). Similarly, it prevents protein adsorption and subsequent loss on product-contact surfaces (e.g. filters, primary/closed containers, and IV tubing), which plays a critical role in ensuring accurate dose delivery to patients.   PS20 and PS80 may also stabilize proteins through direct interactions, thereby increasing the colloidal stability of proteins. Therapeutic proteins may merge to form aggregates through their hydrophobic plaques. Polysorbates may interact with hydrophobic patches on protein surfaces through hydrophobic interactions, thereby preventing protein aggregation and further aggregate unfolding. However, the direct interaction of surfactants with proteins and the subsequent improvement in protein colloid stability may be protein-specific and not widely applicable. For example, a thermodynamic study showed that polysorbate binds to human serum albumin, however, surfactant binding to the three immunoglobulins studied was found to be very low to negligible.  
  1. What are the causes of Tween degradation and the factors that influence it?
    Because polysorbate degradation may inadvertently affect the quality, efficacy, safety, and stability of protein preparations, drug regulatory authorities are increasingly scrutinizing polysorbate control strategies to ensure that polysorbate levels remain constant during the shelf life of drug products.     The hydrolysis of polysorbates involves the cleavage of fatty acid ester bonds, and the resulting release of free fatty acids can form invisible or visible particles. It has been proposed that enzyme-induced polysorbate hydrolysis is the primary cause of visible and subvisible particle formation affecting product quality, and that polysorbate hydrolysis is limited at typical protein formulation pH.   Polysorbate may also be auto-oxidized by temperature, light, or transition trace metals, generating peroxides that may cause protein oxidation, and generating acids that may lead to a decrease in solution pH.   Degradation of PS80 by hydrolysis leads to slower surface adsorption. Free fatty acids released during hydrolysis also form insoluble particles, which negatively affect protein quality and stability.   Histidine, a commonly used buffer for protein preparations, may have a confounding effect on PS degradation.  
  1. What are the disadvantages of Tween 80 as a stabilizer?
  Tween 80 as a polymer itself fluctuates greatly in purity; high purity Tween 80 is colorless and clear, whereas most Tween products are yellow to brown in color and contain large amounts of impurities or degradation products.   The lipophilic components of Tween 80 include unsaturated fatty acids, which are easily oxidized and degraded to produce additional toxic components, resulting in toxic side effects that can outweigh the benefits of the product. The medical community has confirmed that Tween 80, when used in injectable form, can cause allergic reactions, including shock, dyspnea, hypotension, angioedema, rubella and other anaphylactic symptoms. These adverse reactions can be very severe in human clinical trials.   There are strict restrictions on the use of Tween 80, which is a potentially unsafe excipient that can have a significant impact on human health when used improperly.  
  1. What is the difference between Tween 20 and Tween 80?
    The two are synthesized from different raw materials:  
  1. the synthetic raw materials of Tween 80: polymerization of dehydrated sorbitan monooleate with ethylene oxide;
  1. Tween 20 is synthesized from a mixture of polyoxyethylene dehydrate sorbitan monolaurate and a portion of polyoxyethylene bis dehydrate sorbitan monolaurate.
  The uses of the two are different:  
  1. The use of Tween 80: Tween 80 belongs to polyol-type nonionic surfactant, and it is the most commonly used one among polysorbates. It has significant resistance to electrolytes, strong hydrophilicity, and is widely used in liquid, semi-solid and solid preparations as O/W emulsifier, solubilizer, wetting agent, dispersant and stabilizer;
  1. The use of Tween 20: for the condensation of Spectrum and ethylene oxide, due to its molecule has more hydrophilic groups a polyoxyethylene, so hydrophilic, as a non-ionic detergent. It is often used as oil-in-water (O/W) emulsifier; it can be combined with other emulsifiers such as sodium lauryl sulfate or spironolactone, which can increase the stability of emulsion. It can also be used as solubilizer for some drugs.
  The properties of the two are different:  
  1. Tween 80 properties: Tween 80 peroxide value does not exceed 10, for the light yellow to orange viscous liquid; slightly special odor. The taste is slightly bitter and astringent, with a warm sensation;
  1. Tween 20 properties: Tween 20 is a yellow or amber-colored clear oily liquid, with a special odor and a weak bitter taste.


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