UDAD Application scenarios
1. Gallstone-related diseases
Used to dissolve radiolucent cholesterol gallstones in the gallbladder, provided that gallbladder function is normal. It is also used to prevent gallstone recurrence after gallbladder-preserving surgery.
2. Cholestatic liver diseases
Used to treat cholestatic diseases such as primary biliary cirrhosis, improving liver function by replacing toxic bile acids and promoting bile secretion. It is also used in the treatment of intrahepatic cholestasis of pregnancy.
3. Bile reflux-related diseases
Used to treat bile reflux gastritis. It can also be used for digestive problems caused by bile deficiency, such as bile deficiency steatorrhea and post-ileectomy steatorrhea.
4. Other liver diseases
Clinical studies show that it can be used as an adjunct treatment for autoimmune hepatitis, and its use is being explored in the treatment of non-alcoholic fatty liver disease (NASH), various types of hepatitis, and toxic liver injury.
Description
Ursodeoxycholic acid CAS 128-13-2
| Item |
Specifications |
| Appearance |
White or almost white powder |
| Solubility |
Practically insoluble in water;freely soluble in ethanol(96 per cent);slightly soluble in acetone;practically insoluble in methylene chloride. |
| IR Identification |
IR absorption spectrum should be in accordance with the reference standard. |
| TLC Identification |
The principal spot in the chromatogram obtained with the rest solution(b) is similar in position,colour and size to the principal spot in the chromatogram obtain with reference solution(a). |
| Chemical Identification |
The suspension obtained is greenish-blue. |
| Specific optical |
+58.0º~+62.0º |
| Melting point |
About 202℃ |
| Impurity C |
≤0.1% |
| Impurity A |
≤1.0% |
| Unspecified Impurities |
≤0.1% |
| Total Impurities |
≤1.5% |
| Methanol |
≤3000ppm |
| Isopropanol |
≤5000ppm |
| Ethyl acetate |
≤5000ppm |
| Loss on drying |
≤1.0% |
| Sulfated ash |
≤0.1% |
| Heavy metals |
≤20ppm |
| Total Aerobic Microbial Count |
≤10³cfu/g |
| Total Yeasts&Moulds Count |
≤10²cfu/g |
| Escherichia coli |
Not detected |
| Assay(on dry substance) |
99.0%~101.0% |
| Particle Size |
For reference |
Ursodeoxycholic acid Usage
1. Study finds that ursodeoxycholic acid can be used to prevent neocoronavirus infections, It reduces the number of cellular ACE-receptors on cells making it more difficult for viruses to enter human cells.
2. Ursodeoxycholic acid has a beneficial cholestatic effect as it increases the secretion of bile acids when it enters the patient’s body.
3. It also inhibits the synthesis of cholesterol in the liver, reducing the cholesterol and cholesterol esters contained in the bile. In addition, studies have shown that ursodeoxycholic acid can have an immunomodulatory effect when dealing with chronic liver diseases.
4. Ursodeoxycholic acid is useful for cholesterol reduction and stone dissolution, and can be used for the treatment of small stones in the gallbladder without surgery.
Ursodeoxycholic acid Packaging and Shipping
Packing:25KG/drum
Delivery:General goods
Ursodeoxycholic acid Storage
Storage Conditions:Storeinacool,dry,well-ventilated place.
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