Pyridinium chlorochromate Application scenarios
1. Selective Oxidation of Alcohols
Under room temperature and neutral conditions, primary alcohols are oxidized to aldehydes, and secondary alcohols to ketones, without over-oxidation to carboxylic acids or destruction of sensitive groups such as carbon-carbon double bonds (C=C) in the molecule.
2. Synthesis of Natural Products and Complex Molecules
Used for the synthesis of structure-sensitive natural products. For example, in the synthesis of lactones, lactone alcohols can be oxidized to lactone aldehydes without destroying the lactone ring.
3. Oxidation at the Allyl and Benzylic Positions
Specifically oxidizes the methylene (-CH2-) of allyl and benzyl groups to generate the corresponding unsaturated aldehydes or aromatic aldehydes.
4. Transformation of Other Functional Groups
• Oxidation of boranes to carbonyl compounds.
• Oxidation of oximes (deoxime reaction) to carbonyl compounds.
• Oxidative cleavage of alkenes, especially aryl-substituted alkenes.
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