{"id":3661,"date":"2024-05-15T02:46:16","date_gmt":"2024-05-15T02:46:16","guid":{"rendered":"https:\/\/longchangchemical.com\/?post_type=product&p=3661"},"modified":"2025-12-16T09:39:36","modified_gmt":"2025-12-16T09:39:36","slug":"hydroxypinacolone-retinoate-cas-893412-73-2","status":"publish","type":"product","link":"https:\/\/longchangchemical.com\/tr\/product\/hydroxypinacolone-retinoate-cas-893412-73-2\/","title":{"rendered":"hidroksipinakolon retinoat cas 893412-73-2"},"content":{"rendered":"

hidroksipinakolon retinoat cas 893412-73-2<\/strong><\/h1>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n
G\u00f6r\u00fcn\u00fc\u015f<\/td>\nSar\u0131 toz veya kristal<\/td>\n<\/tr>\n
Tan\u0131mlama<\/td>\nUygundur<\/td>\n<\/tr>\n
\u00e7\u00f6z\u00fcn\u00fcrl\u00fck<\/td>\nSuda \u00e7\u00f6z\u00fcnmez<\/td>\n<\/tr>\n
Ate\u015fleme \u00fczerinde kal\u0131nt\u0131<\/td>\n\u22640,1%<\/td>\n<\/tr>\n
A\u011f\u0131r metal<\/td>\n\u226420ppm<\/td>\n<\/tr>\n
Tahlil<\/td>\n\u226595.0%<\/td>\n<\/tr>\n
G\u00f6r\u00fcn\u00fc\u015f<\/td>\nSar\u0131 toz veya kristal<\/td>\n<\/tr>\n
Tan\u0131mlama<\/td>\nUygundur<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

 <\/p>\n

Hidroksipinakolon Retinoat Kullan\u0131m\u0131<\/strong><\/p>\n

Hidroksi pinakolon retinoat, epidermisin ve stratum korneumun metabolizmas\u0131n\u0131 d\u00fczenleme i\u015flevine sahip, ya\u015flanmay\u0131 geciktirmek i\u00e7in kullan\u0131labilen, seboreyi azaltabilen, epidermal pigmentasyonu hafifletebilen ve cilt ya\u015flanmas\u0131n\u0131 \u00f6nlemede, akneyi \u00f6nlemede ve lekeleri beyazlatmada ve ayd\u0131nlatmada rol oynayan bir retinol t\u00fcrevidir. Retinol\u00fcn g\u00fc\u00e7l\u00fc etkisini sa\u011flarken tahri\u015fini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde azalt\u0131r ve \u015fu anda ya\u015flanma kar\u015f\u0131t\u0131 ve akne alevlenmelerinin \u00f6nlenmesi i\u00e7in kullan\u0131lmaktad\u0131r.<\/strong><\/p>\n

1. Akne temizleme
\n2. K\u0131r\u0131\u015f\u0131kl\u0131k Kar\u015f\u0131t\u0131
\n3. Cilt rengini ayd\u0131nlat\u0131n
\nKatk\u0131 maddesi miktar\u0131: 0.1 ~ 0.3%<\/p>\n

Hidroksipinakolon Retinoat Paketleme ve Sevkiyat<\/strong><\/p>\n

Paketleme G\/Al\u00fcminyum folyo \u00e7anta<\/p>\n

Hidroksipinakolon Retinoat Depolama<\/strong><\/p>\n

Serin, havaland\u0131r\u0131lm\u0131\u015f bir depoda saklay\u0131n. Depolama s\u0131cakl\u0131\u011f\u0131 37 \u00b0 C'yi ge\u00e7memelidir. Oksidanlardan ve yenilebilir kimyasallardan ayr\u0131 olarak depolanmal\u0131 ve kar\u0131\u015f\u0131k depolamadan ka\u00e7\u0131n\u0131lmal\u0131d\u0131r.<\/p>\n

\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/span><\/h2>\n

Fiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz info@longchangchemical.com<\/a><\/span> \u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/span><\/h4>\n

<\/p>\n

Retinol'e Yeni Alternatifler<\/strong><\/h2>\n

HPR olarak k\u0131salt\u0131lan hidroksi pinakol bak\u0131r retinoat, yeni bir retinoid t\u00fcrevidir. Retinoik asit ve k\u00fc\u00e7\u00fck molek\u00fcl pinakol\u00fcn esterle\u015fmesiyle olu\u015fur. Di\u011fer retinoik asit t\u00fcrevlerinin aksine, HPR retinoik asidin etkinlik grubunu korur ve retinoik aside d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesine gerek yoktur, bu nedenle do\u011frudan retinoik asit resept\u00f6r\u00fc \u00fczerinde hareket edebilir ve bir rol oynayabilir ve ya\u015flanma kar\u015f\u0131t\u0131 etkisi all-trans retinoik asit ile benzerdir. Bu makale kullan\u0131mdaki baz\u0131 avantajlar\u0131n\u0131 a\u00e7\u0131klayacakt\u0131r.<\/p>\n

Hidroksi pinakolon retinoat<\/p>\n

Daha nazik.
\nBilim insanlar\u0131, insan cildinin in vitro modelinde \u00e7oklu A vitamininin (HPR, trans retinoik asit, retinol, retinaldehit ve retinil palmitat dahil) etkilerini ya\u015flanma kar\u015f\u0131t\u0131 ve tahri\u015f a\u00e7\u0131s\u0131ndan kar\u015f\u0131la\u015ft\u0131rd\u0131. Bu \u00e7al\u0131\u015fma, HPR'nin retinoik asitten daha zay\u0131f inflamasyona (IL-1\u03b1 ile etiketlenmi\u015f) neden oldu\u011funu bulmu\u015ftur. Sitotoksisite de 10 kat konsantrasyonda daha d\u00fc\u015f\u00fckt\u00fc. Bu nedenle, HPR retinoik aside g\u00f6re daha stabil ve daha hafif bir alternatiftir ve kozmetikte kullan\u0131labilir.<\/p>\n

Daha Etkili
\nK\u0131r\u0131\u015f\u0131kl\u0131k Kar\u015f\u0131t\u0131
\nHidroksi pinakolon retinoid i\u00e7eren \u00fcr\u00fcn kullan\u0131larak, 0. (W0), 14. (W14) ve 28. (W28) g\u00fcnlerde deneklerden lokal olarak al\u0131nan gamze hacmi, k\u0131r\u0131\u015f\u0131kl\u0131klar ve ince \u00e7izgilerin g\u00f6r\u00fcnt\u00fcleri, WL-HPR1130 serumu i\u00e7eren numunenin 2 hafta ve 4 hafta boyunca kullan\u0131lmas\u0131ndan sonra, deneklerin g\u00f6z k\u00f6\u015fesindeki gamze hacminin, k\u0131r\u0131\u015f\u0131kl\u0131klar\u0131n ve ince \u00e7izgilerin \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015fti\u011fi ve azalma e\u011filimi g\u00f6sterdi\u011fi g\u00f6zlemlenebilir.<\/p>\n

Keratin metabolizmas\u0131n\u0131 destekler
\nHidroksipinakolon retinoat (HPR) keratin metabolizmas\u0131n\u0131 h\u0131zland\u0131rarak, keratinositlerin d\u00fczg\u00fcn bir \u015fekilde farkl\u0131la\u015fmas\u0131n\u0131 sa\u011flayarak ve interstisyel lipidlerin sentezini te\u015fvik ederek g\u00f6zenekleri azalt\u0131r ve cilt p\u00fcr\u00fczl\u00fcl\u00fc\u011f\u00fcn\u00fc azalt\u0131r, bu da daha p\u00fcr\u00fczs\u00fcz, daha e\u015fit bir cilt ile sonu\u00e7lan\u0131r.<\/p>\n

HPR keratin metabolizmas\u0131 yoluyla sivilceleri azalt\u0131r, folik\u00fcler a\u00e7\u0131kl\u0131k t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131 azalt\u0131r ve ya\u011f bezlerinin ya\u011f salg\u0131lamas\u0131n\u0131 engeller, b\u00f6ylece akne patlamalar\u0131n\u0131 azalt\u0131r ve cilt iltihab\u0131n\u0131n bast\u0131r\u0131lmas\u0131n\u0131 ve ortadan kald\u0131r\u0131lmas\u0131n\u0131 sa\u011flar. Ayr\u0131ca keratin metabolizmas\u0131 yoluyla cildi beyazlatabilir, melanositlerin bo\u015falmas\u0131n\u0131 h\u0131zland\u0131r\u0131r ve melanosit \u00fcretimini azalt\u0131r.<\/p>\n

Daha kararl\u0131
\nAra\u015ft\u0131rmac\u0131lar A vitamini analoglar\u0131n\u0131n \u0131\u015f\u0131\u011fa duyarl\u0131l\u0131\u011f\u0131n\u0131 test etmi\u015f ve test edilen t\u00fcm A vitaminleri aras\u0131nda retinil palmitat (Rpal) ve beta karoten (\u03b2cal) \u0131\u015f\u0131\u011fa daha kolay bozunarak bir hafta \u0131\u015f\u0131\u011fa maruz kald\u0131ktan sonra neredeyse tamamen bozunurken, hidroksipinakolon retinil palmitat (HPR) bir hafta sonra sadece y\u00fczde 40 oran\u0131nda bozunmu\u015ftur. Ortalama olarak, \u0131\u015f\u0131\u011fa maruz kalma, test edilen t\u00fcm A vitaminleri aras\u0131nda HPR'nin stabilitesi \u00fczerinde en az etkiye sahip olmu\u015ftur.<\/p>\n

Buna ek olarak, makalenin deneysel verilerine g\u00f6re, HPR, sim\u00fcle edilmi\u015f uzun vadeli stabilite testinde (25\u00b0C'de 6 ay ve 60% nem) ve h\u0131zland\u0131r\u0131lm\u0131\u015f stabilite testinde (40\u00b0C, UV'ye maruz kalan ortam) form\u00fclasyonda \u00e7ok stabil kalm\u0131\u015ft\u0131r (ba\u015flang\u0131\u00e7taki 95% i\u00e7eri\u011finden esasen de\u011fi\u015fmeden). Di\u011fer birka\u00e7 A s\u0131n\u0131f\u0131 t\u00fcrev i\u00e7in \u00f6nemli bozulma g\u00f6sterilmi\u015ftir.<\/p>\n

\u00d6zet
\nHidroksi pinakolon retinoat, d\u00f6n\u00fc\u015ft\u00fcrme i\u015flemi olmaks\u0131z\u0131n do\u011frudan retinoik asit resept\u00f6r\u00fcne ba\u011flanabilen ve h\u0131zl\u0131 bir etki ba\u015flang\u0131c\u0131na sahip olan do\u011frudan bir etkiye sahiptir; k\u00fc\u00e7\u00fck bir molek\u00fcler a\u011f\u0131rl\u0131kla, transdermal olarak daha kolay emilme, d\u00fc\u015f\u00fck tahri\u015f, y\u00fcksek aktivite ve y\u00fcksek stabilite avantaj\u0131na sahiptir, bu sadece etkinlik a\u00e7\u0131s\u0131ndan geleneksel retinolden daha iyi de\u011fil, ayn\u0131 zamanda g\u00fcvenlik a\u00e7\u0131s\u0131ndan da daha iyidir ve uygulama i\u00e7in b\u00fcy\u00fck bir potansiyele sahiptir.<\/p>","protected":false},"excerpt":{"rendered":"

Kimyasal Ad\u0131:Hidroksipinakolon Retinoat<\/p>\n

CAS No: 893412-73-2<\/p>\n

Molek\u00fcler Form\u00fcl: C26H38O3<\/p>\n

Molek\u00fcler A\u011f\u0131rl\u0131k:398.57812<\/p>\n

Molek\u00fcler Yap\u0131:\"Hidroksipinakolon<\/p>\n

G\u00f6r\u00fcn\u00fcm:Sar\u0131 toz veya kristal<\/p>\n

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