Hyaluronik asit ile ilk tan\u0131\u015fma<\/p>\n\n\n\n
Hyaluronik asit, hyaluronik asidin ortak ad\u0131d\u0131r. Disakkarit birimleri D-glukuronik asit ve N-asetilglukozaminden olu\u015fan s\u00fclf\u00fcr i\u00e7ermeyen lineer bir mukopolisakkarittir. \u0130nsan v\u00fccudunun ba\u011f dokusunda, epitel dokusunda ve sinirlerinde yayg\u0131n olarak bulunur. Organizasyon i\u00e7inde. 1934 y\u0131l\u0131nda hyaluronik asit, Columbia \u00dcniversitesi'nden Karl Meyer ve John Palmer taraf\u0131ndan s\u0131\u011f\u0131r vitr\u00f6z\u00fcnden ayr\u0131\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n
Mevcut durumda tibbi\u0307 kozmetoloji\u0307 sekt\u00f6r\u00fc<\/a>hyaluronik asit, kozmetik dolgu maddesi olarak yayg\u0131n bir \u015fekilde kullan\u0131lmaktad\u0131r. Genellikle nemlendirme, ya\u011flama ve \u015fekillendirme rol\u00fcn\u00fc oynamak i\u00e7in dermise enjekte edilir. Mikro plastik cerrahi alan\u0131nda, rinoplasti, \u00e7ene dolgusu, dudak b\u00fcy\u00fctme ve k\u0131r\u0131\u015f\u0131kl\u0131k \u00f6nleyici gibi dolgu maddeleri olarak veya nemlendirici su-\u0131\u015f\u0131k enjeksiyonlar\u0131 i\u00e7in enjeksiyon \u00fcr\u00fcnleri olarak kullan\u0131labilir, t\u0131bbi estetik dolgu pazar\u0131nda \u00f6nemli bir paya sahiptir.<\/p>\n\n\n\n Hyaluronik asit ilk olarak 2003 y\u0131l\u0131nda FDA taraf\u0131ndan cilt k\u0131r\u0131\u015f\u0131kl\u0131klar\u0131n\u0131n tedavisinde kullan\u0131lmak \u00fczere onaylanm\u0131\u015ft\u0131r. Daha sonra, su tutma ve su kilitleme i\u015flevleri nedeniyle, su-\u0131\u015f\u0131k akupunkturu gibi t\u0131bbi cilt yenileme i\u00e7in kademeli olarak kullan\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n Farkl\u0131 molek\u00fcler a\u011f\u0131rl\u0131klara g\u00f6re hyaluronik asit \u00fc\u00e7 kategoriye ayr\u0131labilir: makromolek\u00fcller, orta molek\u00fcller ve k\u00fc\u00e7\u00fck molek\u00fcller. Molek\u00fcler a\u011f\u0131rl\u0131k \u00f6nemli bir parametredir. Farkl\u0131 molek\u00fcler a\u011f\u0131rl\u0131ktaki hyaluronik asidin fonksiyonel uygulama alanlar\u0131 farkl\u0131d\u0131r.<\/p>\n\n\n\n D\u00fcnyan\u0131n ana hyaluronik asit hammadde kayna\u011f\u0131<\/p>\n\n\n\n 2018 y\u0131l\u0131nda \u00fclkemin hyaluronik asit hammadde sat\u0131\u015flar\u0131 430 tona ula\u015farak k\u00fcresel sat\u0131\u015flar\u0131n 86%'sini olu\u015fturdu ve hammadde pazar b\u00fcy\u00fckl\u00fc\u011f\u00fc 3,07 milyara ula\u015ft\u0131. \u00dcr\u00fcn yap\u0131s\u0131 a\u00e7\u0131s\u0131ndan bak\u0131ld\u0131\u011f\u0131nda, yerli hyaluronik asit hammaddeleri a\u011f\u0131rl\u0131kl\u0131 olarak d\u00fc\u015f\u00fck katma de\u011ferli kozmetik ve g\u0131da s\u0131n\u0131flar\u0131nda yo\u011funla\u015fmaktad\u0131r ve y\u00fcksek katma de\u011ferli farmas\u00f6tik s\u0131n\u0131f hammaddeler d\u00fc\u015f\u00fck bir orana sahiptir.<\/p>\n\n\n\n Sat\u0131\u015f hacmi a\u00e7\u0131s\u0131ndan, \u015fu anda d\u00fcnyadaki ilk 5 hyaluronik asit hammaddesi \u00fcreticisinin tamam\u0131 \u00c7inli \u015firketlerdir. Pazar pay\u0131na g\u00f6re bunlar Huaxi Biological (36%), Focus Biological (12%), Fufeng Biological (10%) , Dongchen Biological (8%) ve Anhua Biological (7%).<\/p>\n\n\n\n Medikal g\u00fczellik end\u00fcstrisinde kullan\u0131lan hyaluronik asit hammaddelerinin ve son \u00fcr\u00fcnlerinin farmas\u00f6tik s\u0131n\u0131f hyaluronik asit olmas\u0131 gerekmektedir. Hammadde \u00fcreticisinin farmas\u00f6tik s\u0131n\u0131f hyaluronik asit hammaddelerinin \u00fcretimi i\u00e7in yeterlilik almas\u0131 gerekir ve hammadde \u00fcr\u00fcnlerinin safl\u0131\u011f\u0131, protein safs\u0131zl\u0131klar\u0131 ve a\u011f\u0131r metal i\u00e7eri\u011fi gibi teknik g\u00f6stergelere sahiptir. Daha y\u00fcksek gereksinimlerle, farmas\u00f6tik s\u0131n\u0131f hammaddeler, yerli hyaluronik asit hammaddelerinin toplam sat\u0131\u015flar\u0131n\u0131n yaln\u0131zca 2.3%'sini olu\u015fturmaktad\u0131r ve bu da d\u00fcnya ortalamas\u0131n\u0131n \u00e7ok alt\u0131ndad\u0131r. Bu alanda faaliyet g\u00f6steren yerli \u00fcretim \u015firketleri \u00e7o\u011funlukla Huaxi Biology ve Zhongshan Biology'dir.<\/p>\n\n\n\n Yurti\u00e7i medikal estetik dolgulu hyaluronik asit pazar\u0131na ithal \u00fcr\u00fcnler hakim<\/p>\n\n\n\n T\u0131bbi g\u00fczellik end\u00fcstrisindeki t\u0131bbi s\u0131n\u0131f hyaluronik asit terminal \u00fcr\u00fcnleri esas olarak enjeksiyon kozmetik dolgu \u00fcr\u00fcnleridir ve \u00fcr\u00fcnlerin katma de\u011feri y\u00fcksektir. Bitmi\u015f \u00fcr\u00fcnlerin NMPA S\u0131n\u0131f III t\u0131bbi cihazlar taraf\u0131ndan onaylanmas\u0131 gerekir. 2018 y\u0131l\u0131nda, \u00fclkemin medikal estetik dolgulu hyaluronik asit pazar b\u00fcy\u00fckl\u00fc\u011f\u00fc, 17%'den fazla y\u0131ll\u0131k bile\u015fik b\u00fcy\u00fcme oran\u0131yla 3,7 milyar yuan'a ula\u015ft\u0131 ve yerel farmas\u00f6tik dereceli hyaluronik asit pazar\u0131n\u0131n b\u00fcy\u00fcmesi i\u00e7in ana itici g\u00fc\u00e7 haline geldi.<\/p>\n\n\n\n \u015eu anda, \u00c7in'de NMPA sertifikas\u0131 ile onaylanm\u0131\u015f, 6's\u0131 ithal ve 8'i yerli olmak \u00fczere 14 \u015firkete ait 27 enjeksiyonluk hyaluronik asit \u00fcr\u00fcn\u00fc bulunmaktad\u0131r. Kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ithal \u00fcr\u00fcnlerin marka avantaj\u0131 a\u00e7\u0131kt\u0131r, \u00fcr\u00fcnlerin \u00e7o\u011fu yerli \u00fcr\u00fcnlerden daha y\u00fcksek fiyatl\u0131d\u0131r; yerli ithal \u00fcr\u00fcnlerin konsantrasyonu 20mg\/ml ~ 24mg\/ml aras\u0131ndad\u0131r ve yerli \u00fcr\u00fcnlerin konsantrasyonu \u00e7o\u011funlukla 16mg\/ml ~ 20mg\/ml'dir Bu arada, \u00e7o\u011fu \u00fcr\u00fcn yar\u0131m y\u0131ldan bir y\u0131la kadar dayanabilir ve plastik etkiyi korumak i\u00e7in yeniden doldurmak genellikle yar\u0131m y\u0131l veya bir y\u0131l s\u00fcrer.<\/p>\n\n\n\n Sat\u0131\u015f miktar\u0131 a\u00e7\u0131s\u0131ndan bak\u0131ld\u0131\u011f\u0131nda, 2018 y\u0131l\u0131nda hyaluronik asit medikal estetik terminal pazar\u0131n\u0131n b\u00fcy\u00fckl\u00fc\u011f\u00fc 3,7 milyar yuan olmu\u015ftur. Koreli \u015firketler ile Avrupal\u0131 ve Amerikal\u0131 \u015firketler ilk iki i\u00e7 pazar pay\u0131n\u0131 olu\u015fturdu ve ikisinin birle\u015fik pazar pay\u0131 74,7% oldu. Yerli medikal estetik dolgulu hyaluronik asit pazar\u0131na hakimdir. Temsilci \u015firketler G\u00fcney Kore \u015firketleri LG (25.50%), Humedix (13.20%), Amerikan Allergan (19.4%) ve \u0130sve\u00e7 Q-Med (12.20%); yerel \u015firketler 23.4% \u015eirketin toplam pazar pay\u0131 \u00fc\u00e7\u00fcnc\u00fc s\u0131rada yer al\u0131yor ve ana \u015firketler Haohai Biological (18.4%), Amic (12.5%) ve Huaxi Biological (11.5%).<\/p>\n\n\n\n Farkl\u0131 marka \u00fcr\u00fcnlerin temel farkl\u0131l\u0131klar\u0131<\/p>\n\n\n\n Modifiye edilmemi\u015f do\u011fal hyaluronik asidin cilt, g\u00f6zler, eklemler ve di\u011fer b\u00f6lgelerdeki yar\u0131lanma \u00f6mr\u00fc yakla\u015f\u0131k 1 ila 21 g\u00fcn aras\u0131nda de\u011fi\u015fmektedir. Bu \u00f6zellik hyaluronik asidin medikal estetik end\u00fcstrisindeki uygulamalar\u0131n\u0131 s\u0131n\u0131rlamaktad\u0131r. \u00c7apraz ba\u011flama ajanlar\u0131 ve farkl\u0131 \u00e7apraz ba\u011flama teknolojileri kullan\u0131larak hyaluronik asidin \u00f6zelliklerinin de\u011fi\u015ftirilmesi, hyaluronik asidin doldurma ve \u015fekillendirme kabiliyetini ve v\u00fccuttaki dayan\u0131kl\u0131l\u0131k s\u00fcresini de\u011fi\u015fen derecelerde art\u0131rabilir.<\/p>\n\n\n\n Ancak bu t\u00fcr bir \u00e7apraz ba\u011flama teknolojisinin y\u00fcksek bir e\u015fi\u011fi vard\u0131r. Hyaluronik asidin performans\u0131n\u0131 art\u0131r\u0131rken, \u00fcr\u00fcn\u00fcn g\u00fcvenli\u011fini de g\u00f6z \u00f6n\u00fcnde bulundurmak gerekir. \u00d6zellikle g\u00fcvenli\u011fin \u00f6nemi, \u00fcr\u00fcn performans\u0131n\u0131n iyile\u015ftirilmesinden \u00e7ok daha fazlad\u0131r. Raporlara g\u00f6re, hyaluronik asit ile kombine edilmeyen \u00e7apraz ba\u011flay\u0131c\u0131 ajanlar v\u00fccutta serbest halde bulunduklar\u0131nda DNA'ya ba\u011flanabilmekte ve olduk\u00e7a toksik ve kanserojen olabilmektedir. Ger\u00e7ek \u00fcretim s\u00fcrecinde, kalan \u00e7apraz ba\u011flama maddesi miktar\u0131n\u0131n g\u00fcvenli bir aral\u0131kta kontrol edilmesi gerekir. \u0130\u00e7eride. Bu nedenle, \u00e7apraz ba\u011flama teknolojisi, farkl\u0131 markalar\u0131n \u00fcr\u00fcnleri aras\u0131ndaki temel fark ve patent d\u00fczeninin odak noktas\u0131d\u0131r.<\/p>\n\n\n\n \u015eu anda, FDA sertifikal\u0131 hyaluronik asit dolgulu \u00fcr\u00fcnlerde kullan\u0131lan \u00e7apraz ba\u011flama ajanlar\u0131 aras\u0131nda BDDE (b\u00fctanol glisidil eter) ve DVS (divinil s\u00fclfon) bulunmaktad\u0131r. BDDE, \u00e7apraz ba\u011flama i\u00e7in yerel medikal estetik end\u00fcstrisinde \u00f6nerilmekte ve yayg\u0131n olarak kullan\u0131lmaktad\u0131r.<\/p>\n\n\n\n H\u0131zl\u0131 cevap:<\/strong> Pratik bir kimyasal tedarik karar\u0131, \u00f6ncelikle kullan\u0131m amac\u0131ndan yola \u00e7\u0131kar; ard\u0131ndan \u00f6l\u00e7ek b\u00fcy\u00fctme a\u015famas\u0131na ge\u00e7ilmeden \u00f6nce safl\u0131k, uyumluluk, depolama ko\u015fullar\u0131 ve i\u015flem s\u0131ras\u0131ndaki davran\u0131\u015flar\u0131 do\u011frulan\u0131r.<\/p>\n\n\n\n\n\n\n\n COA, MSDS veya TDS'ye ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi girin, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz info@longchangchemical.com<\/a> \u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/strong> <\/p>\n\n\n\n Bu makale Longchang Kimya Ar-Ge Departman\u0131 taraf\u0131ndan yaz\u0131lm\u0131\u015ft\u0131r. Kopyalaman\u0131z ve yeniden basman\u0131z gerekiyorsa, l\u00fctfen kayna\u011f\u0131 belirtin. <\/strong><\/p>\n\n\n\n Genel kimyasal kararlar, ekipler teoriden uygulamaya ge\u00e7i\u015f yapt\u0131\u011f\u0131nda genellikle daha net hale gelir: malzemenin ne yapmas\u0131 gerekti\u011fi, ne kadar saf olmas\u0131 gerekti\u011fi, ger\u00e7ek s\u00fcre\u00e7te nas\u0131l davrand\u0131\u011f\u0131 ve hangi sonraki a\u015fama k\u0131s\u0131tlamalar\u0131n\u0131 kar\u015f\u0131lamas\u0131 gerekti\u011fi gibi konular ele al\u0131n\u0131r.<\/p>\n Ka\u011f\u0131t \u00fczerinde do\u011fru g\u00f6r\u00fcnen bir malzeme neden kullan\u0131mda yine de d\u00fc\u015f\u00fck performans g\u00f6sterebilir?<\/strong> Teknik kimyasal se\u00e7iminde her zaman en d\u00fc\u015f\u00fck maliyetli se\u00e7enekle mi ba\u015flanmal\u0131d\u0131r?<\/strong> First acquaintance with hyaluronic acid Hyaluronic acid is the common name of hyaluronic acid. It is a non-sulfur linear mucopolysaccharide composed of disaccharide units D-glucuronic acid and N-acetylglucosamine. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4909","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\n \u015eimdi Bize Ula\u015f\u0131n!<\/strong> <\/strong><\/h2>\n\n\n
Genel end\u00fcstriyel kimyasallar i\u00e7in pratik bir tedarik kontrol listesi<\/h2>\n
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\u00d6nerilen \u00fcr\u00fcn referanslar\u0131<\/h3>\n
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Al\u0131c\u0131lar ve form\u00fclat\u00f6rler i\u00e7in SSS<\/h3>\n
\u00c7\u00fcnk\u00fc ger\u00e7ek d\u00fcnya proses ko\u015fullar\u0131, substrat etkile\u015fimi ve depolama davran\u0131\u015f\u0131, basitle\u015ftirilmi\u015f bir spesifikasyon incelemesinde a\u00e7\u0131k\u00e7a g\u00f6r\u00fclmeyen sorunlar\u0131 ortaya \u00e7\u0131karabilir.<\/p>\n
Genellikle de\u011fil. Proses uyumlulu\u011fu, istikrar ve nihai kalite dikkate al\u0131nd\u0131\u011f\u0131nda, en d\u00fc\u015f\u00fck sat\u0131n alma fiyat\u0131 her zaman en d\u00fc\u015f\u00fck kullan\u0131m maliyeti anlam\u0131na gelmez.<\/p>\n","protected":false},"excerpt":{"rendered":"