P vitamini olarak da bilinen Rutin'in molek\u00fcler form\u00fcl\u00fc C27<\/sub>H30<\/sub>O16<\/sub>. Rutinin kimyasal yap\u0131s\u0131 \u015eekil 1'de g\u00f6sterilmi\u015ftir. Anti-inflamatuar, anti-oksidan, anti-alerjik ve anti-viral etkileri olan do\u011fal bir flavonoid glikozittir. Rutinin erime noktas\u0131 yakla\u015f\u0131k 178 \u2103'dir ve oda s\u0131cakl\u0131\u011f\u0131nda sar\u0131 bir kristaldir. I\u015f\u0131\u011fa maruz kald\u0131\u011f\u0131nda rengi koyula\u015f\u0131r ve ac\u0131 bir tada sahiptir. Suda d\u00fc\u015f\u00fck \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011fe sahiptir, metanol, etanolde kolayca \u00e7\u00f6z\u00fcn\u00fcr ve petrol eteri gibi d\u00fc\u015f\u00fck polariteye sahip organik reaktiflerde \u00e7\u00f6z\u00fcnmez. Rutin, bitkilerin k\u00f6klerinde, g\u00f6vdelerinde, yapraklar\u0131nda ve di\u011fer k\u0131s\u0131mlar\u0131nda yayg\u0131n olarak bulunur ve i\u00e7eri\u011fi Sophora japonicus, Rutinous herb, Eclipta prostrata ve karabu\u011fday gibi bitkilerde daha y\u00fcksektir. \u015eu anda rutin, end\u00fcstriyel \u00fcretimde \u00e7o\u011funlukla Sophora japonica'dan \u00e7\u0131kar\u0131lmaktad\u0131r ve i\u00e7eri\u011fi 23.0%'den daha fazlas\u0131na ula\u015fabilmektedir. Co\u011frafi da\u011f\u0131l\u0131m a\u00e7\u0131s\u0131ndan, Sophora japonica'daki rutin i\u00e7eri\u011fi Henan, Shandong ve Hebei eyaletlerinde daha y\u00fcksektir. Ayr\u0131ca baz\u0131 \u00e7al\u0131\u015fmalar karabu\u011fday, k\u0131rm\u0131z\u0131 hurma, dut yapra\u011f\u0131 ve di\u011fer bitkilerin de belirli miktarda rutin i\u00e7erdi\u011fini g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\")
<\/figure>\r\n\r\n\r\n\r\n\u015eekil 1 Rutinin kimyasal yap\u0131s\u0131<\/h5>\r\n\r\n\r\n\r\nApocynum A olarak da bilinen Isoquercitrin, derhamnosyl'den t\u00fcretilmi\u015f bir rutin t\u00fcrevidir. Molek\u00fcler form\u00fcl\u00fc C21<\/sub>H20<\/sub>O12<\/sub>. \u0130zoquercitrin'in kimyasal yap\u0131s\u0131 \u015eekil 2'de g\u00f6sterilmi\u015ftir. Isoquercitrin yakla\u015f\u0131k 226 \u00b0C erime noktas\u0131na sahiptir ve oda s\u0131cakl\u0131\u011f\u0131nda sar\u0131 bir kristaldir. Sudaki \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc d\u00fc\u015f\u00fckt\u00fcr, oda s\u0131cakl\u0131\u011f\u0131nda sadece 25,9 mg\/L'dir. Alkali suda \u00e7\u00f6z\u00fcnd\u00fckten sonra koyula\u015f\u0131r. Isoquercitrin, Saururus chinensis, Houttuynia cordata, Rhododendron alt\u0131n yapra\u011f\u0131, ormang\u00fcl\u00fc, Ginkgo biloba, Morus dutu ve Elaeagnus deniz dikeni gibi bitkilerde yayg\u0131n olarak bulunur. Bununla birlikte, izoquercitrin'in bitkilerdeki do\u011fal i\u00e7eri\u011fi d\u00fc\u015f\u00fckt\u00fcr, ortalama olarak sadece birka\u00e7 on binde birdir, bu nedenle \u00e7o\u011funlukla sentetik y\u00f6ntemlerle haz\u0131rlan\u0131r. Modern farmakolojik \u00e7al\u0131\u015fmalar, isoquercitrin'in farmakolojik aktivitesinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu ve t\u0131bbi de\u011ferinin daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-2.png\")
<\/figure>\r\n\r\n\r\n\r\n\u015eekil 2 \u0130zoquercitrin'in kimyasal yap\u0131s\u0131<\/h5>\r\n\r\n\r\n\r\n2. \u0130zoquercitrin'in haz\u0131rlanmas\u0131<\/h3>\r\n\r\n\r\n\r\nIsoquercitrin bitkilerde d\u00fc\u015f\u00fck bir do\u011fal i\u00e7eri\u011fe sahiptir ve genellikle asit hidrolizi, y\u00fcksek bas\u0131n\u00e7l\u0131 hidroliz ve end\u00fcstrideki di\u011fer y\u00f6ntemlerle haz\u0131rlan\u0131r. \u00c7al\u0131\u015fmalar, izoquercitrin monomerini bitki \u00f6zlerinden ay\u0131rmak i\u00e7in kolon kromatografisini kullanm\u0131\u015ft\u0131r. \u00d6rne\u011fin, Shi Xin ve arkada\u015flar\u0131 Yidianhong t\u0131bbi malzemelerinden > 98.0% safl\u0131kta izoquercitrin ay\u0131rmak i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi kullanm\u0131\u015flard\u0131r; Yin Li 580 mg Huangdingju'dan izoquercitrin elde etmek i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi ile birlikte makrog\u00f6zenekli re\u00e7ine kolon kromatografisi kullanm\u0131\u015ft\u0131r Alkol ekstrakt\u0131ndan 9.3 mg izoquercitrin izole edilmi\u015ftir ve safl\u0131\u011f\u0131 95.8%'dir. Bununla birlikte, bitkilerdeki d\u00fc\u015f\u00fck do\u011fal izoquercitrin i\u00e7eri\u011fi nedeniyle, bu y\u00f6ntem sadece d\u00fc\u015f\u00fck bir verime sahip olmakla kalmaz, ayn\u0131 zamanda b\u00fcy\u00fck bir i\u015f y\u00fck\u00fcne ve \u00e7ok fazla reaktif t\u00fcketimine sahiptir, bu da end\u00fcstriyel uygulamadaki uygulamas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar. Yu Ting ve arkada\u015flar\u0131, izoquercitrin i\u00e7in h\u0131zl\u0131 bir haz\u0131rlama y\u00f6ntemi olu\u015fturmak \u00fczere y\u00fcksek bas\u0131n\u00e7l\u0131 hidrolizi SG64 re\u00e7ine kromatografik ay\u0131rma teknolojisi ile birle\u015ftirmi\u015ftir. Bununla birlikte, hidroliz ko\u015fullar\u0131n\u0131n kontrol edilmesi kolay de\u011fildir ve izoquercitrin verimi d\u00fc\u015f\u00fckt\u00fcr. \u00dcr\u00fcn, daha fazla hidrolizle elde edilen b\u00fcy\u00fck miktarda hidrolize edilmemi\u015f rutin ve kuersetin i\u00e7erir, bu da sonraki ay\u0131rman\u0131n zorlu\u011funu art\u0131r\u0131r.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-1.png\")
<\/figure>\r\n\r\n\r\n\r\nMikrobiyal d\u00f6n\u00fc\u015f\u00fcm ve enzim katalizli d\u00f6n\u00fc\u015f\u00fcm gibi biyoteknoloji, esasen yabanc\u0131 bile\u015fiklerin yap\u0131s\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in serbest enzimler veya kompleks enzimler kullanan metabolik bir reaksiyondur. Hafif ko\u015fullar, g\u00fc\u00e7l\u00fc se\u00e7icilik, az say\u0131da yan \u00fcr\u00fcn, temiz ve \u00e7evre dostu ve d\u00fc\u015f\u00fck maliyet avantajlar\u0131na sahiptir; do\u011fal; Glikozit bile\u015fikleri genellikle daha fazla glikozil grubu i\u00e7erir ve \u00e7ok polard\u0131r, bu nedenle farmakolojik aktivitelerini uygulamak i\u00e7in en iyi yap\u0131 de\u011fildirler. Bunlar\u0131 d\u00fc\u015f\u00fck glikozitlere, aglikonlara veya di\u011fer \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcrmek, etkinliklerini daha iyi g\u00f6stermelerine yard\u0131mc\u0131 olacakt\u0131r. Wang Yuanyuan ve arkada\u015flar\u0131 rutini biyotransforme etmek i\u00e7in Streptomyces griseus kullanm\u0131\u015f ve silika jel kolon kromatografisi ile izoquercitrin dahil 6 d\u00f6n\u00fc\u015f\u00fcm \u00fcr\u00fcn\u00fcn\u00fc ay\u0131rm\u0131\u015flard\u0131r. Daha ileri \u00e7al\u0131\u015fmalar, bu s\u00fcre\u00e7te yer alan reaksiyonlar\u0131n metilasyon ve Glikozit hidrolizi vb. dahil olmak \u00fczere daha karma\u015f\u0131k oldu\u011funu ve Streptomyces griseus'un rutin d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in zay\u0131f \u00f6zg\u00fcll\u00fc\u011fe sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter.png\")
<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-2.png\")
<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\n\u015eekil 1 Rutinin kimyasal yap\u0131s\u0131<\/h5>\r\n\r\n\r\n\r\nApocynum A olarak da bilinen Isoquercitrin, derhamnosyl'den t\u00fcretilmi\u015f bir rutin t\u00fcrevidir. Molek\u00fcler form\u00fcl\u00fc C21<\/sub>H20<\/sub>O12<\/sub>. \u0130zoquercitrin'in kimyasal yap\u0131s\u0131 \u015eekil 2'de g\u00f6sterilmi\u015ftir. Isoquercitrin yakla\u015f\u0131k 226 \u00b0C erime noktas\u0131na sahiptir ve oda s\u0131cakl\u0131\u011f\u0131nda sar\u0131 bir kristaldir. Sudaki \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc d\u00fc\u015f\u00fckt\u00fcr, oda s\u0131cakl\u0131\u011f\u0131nda sadece 25,9 mg\/L'dir. Alkali suda \u00e7\u00f6z\u00fcnd\u00fckten sonra koyula\u015f\u0131r. Isoquercitrin, Saururus chinensis, Houttuynia cordata, Rhododendron alt\u0131n yapra\u011f\u0131, ormang\u00fcl\u00fc, Ginkgo biloba, Morus dutu ve Elaeagnus deniz dikeni gibi bitkilerde yayg\u0131n olarak bulunur. Bununla birlikte, izoquercitrin'in bitkilerdeki do\u011fal i\u00e7eri\u011fi d\u00fc\u015f\u00fckt\u00fcr, ortalama olarak sadece birka\u00e7 on binde birdir, bu nedenle \u00e7o\u011funlukla sentetik y\u00f6ntemlerle haz\u0131rlan\u0131r. Modern farmakolojik \u00e7al\u0131\u015fmalar, isoquercitrin'in farmakolojik aktivitesinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu ve t\u0131bbi de\u011ferinin daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\n\u015eekil 2 \u0130zoquercitrin'in kimyasal yap\u0131s\u0131<\/h5>\r\n\r\n\r\n\r\n2. \u0130zoquercitrin'in haz\u0131rlanmas\u0131<\/h3>\r\n\r\n\r\n\r\nIsoquercitrin bitkilerde d\u00fc\u015f\u00fck bir do\u011fal i\u00e7eri\u011fe sahiptir ve genellikle asit hidrolizi, y\u00fcksek bas\u0131n\u00e7l\u0131 hidroliz ve end\u00fcstrideki di\u011fer y\u00f6ntemlerle haz\u0131rlan\u0131r. \u00c7al\u0131\u015fmalar, izoquercitrin monomerini bitki \u00f6zlerinden ay\u0131rmak i\u00e7in kolon kromatografisini kullanm\u0131\u015ft\u0131r. \u00d6rne\u011fin, Shi Xin ve arkada\u015flar\u0131 Yidianhong t\u0131bbi malzemelerinden > 98.0% safl\u0131kta izoquercitrin ay\u0131rmak i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi kullanm\u0131\u015flard\u0131r; Yin Li 580 mg Huangdingju'dan izoquercitrin elde etmek i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi ile birlikte makrog\u00f6zenekli re\u00e7ine kolon kromatografisi kullanm\u0131\u015ft\u0131r Alkol ekstrakt\u0131ndan 9.3 mg izoquercitrin izole edilmi\u015ftir ve safl\u0131\u011f\u0131 95.8%'dir. Bununla birlikte, bitkilerdeki d\u00fc\u015f\u00fck do\u011fal izoquercitrin i\u00e7eri\u011fi nedeniyle, bu y\u00f6ntem sadece d\u00fc\u015f\u00fck bir verime sahip olmakla kalmaz, ayn\u0131 zamanda b\u00fcy\u00fck bir i\u015f y\u00fck\u00fcne ve \u00e7ok fazla reaktif t\u00fcketimine sahiptir, bu da end\u00fcstriyel uygulamadaki uygulamas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar. Yu Ting ve arkada\u015flar\u0131, izoquercitrin i\u00e7in h\u0131zl\u0131 bir haz\u0131rlama y\u00f6ntemi olu\u015fturmak \u00fczere y\u00fcksek bas\u0131n\u00e7l\u0131 hidrolizi SG64 re\u00e7ine kromatografik ay\u0131rma teknolojisi ile birle\u015ftirmi\u015ftir. Bununla birlikte, hidroliz ko\u015fullar\u0131n\u0131n kontrol edilmesi kolay de\u011fildir ve izoquercitrin verimi d\u00fc\u015f\u00fckt\u00fcr. \u00dcr\u00fcn, daha fazla hidrolizle elde edilen b\u00fcy\u00fck miktarda hidrolize edilmemi\u015f rutin ve kuersetin i\u00e7erir, bu da sonraki ay\u0131rman\u0131n zorlu\u011funu art\u0131r\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nMikrobiyal d\u00f6n\u00fc\u015f\u00fcm ve enzim katalizli d\u00f6n\u00fc\u015f\u00fcm gibi biyoteknoloji, esasen yabanc\u0131 bile\u015fiklerin yap\u0131s\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in serbest enzimler veya kompleks enzimler kullanan metabolik bir reaksiyondur. Hafif ko\u015fullar, g\u00fc\u00e7l\u00fc se\u00e7icilik, az say\u0131da yan \u00fcr\u00fcn, temiz ve \u00e7evre dostu ve d\u00fc\u015f\u00fck maliyet avantajlar\u0131na sahiptir; do\u011fal; Glikozit bile\u015fikleri genellikle daha fazla glikozil grubu i\u00e7erir ve \u00e7ok polard\u0131r, bu nedenle farmakolojik aktivitelerini uygulamak i\u00e7in en iyi yap\u0131 de\u011fildirler. Bunlar\u0131 d\u00fc\u015f\u00fck glikozitlere, aglikonlara veya di\u011fer \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcrmek, etkinliklerini daha iyi g\u00f6stermelerine yard\u0131mc\u0131 olacakt\u0131r. Wang Yuanyuan ve arkada\u015flar\u0131 rutini biyotransforme etmek i\u00e7in Streptomyces griseus kullanm\u0131\u015f ve silika jel kolon kromatografisi ile izoquercitrin dahil 6 d\u00f6n\u00fc\u015f\u00fcm \u00fcr\u00fcn\u00fcn\u00fc ay\u0131rm\u0131\u015flard\u0131r. Daha ileri \u00e7al\u0131\u015fmalar, bu s\u00fcre\u00e7te yer alan reaksiyonlar\u0131n metilasyon ve Glikozit hidrolizi vb. dahil olmak \u00fczere daha karma\u015f\u0131k oldu\u011funu ve Streptomyces griseus'un rutin d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in zay\u0131f \u00f6zg\u00fcll\u00fc\u011fe sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\n\u015eekil 2 \u0130zoquercitrin'in kimyasal yap\u0131s\u0131<\/h5>\r\n\r\n\r\n\r\n2. \u0130zoquercitrin'in haz\u0131rlanmas\u0131<\/h3>\r\n\r\n\r\n\r\nIsoquercitrin bitkilerde d\u00fc\u015f\u00fck bir do\u011fal i\u00e7eri\u011fe sahiptir ve genellikle asit hidrolizi, y\u00fcksek bas\u0131n\u00e7l\u0131 hidroliz ve end\u00fcstrideki di\u011fer y\u00f6ntemlerle haz\u0131rlan\u0131r. \u00c7al\u0131\u015fmalar, izoquercitrin monomerini bitki \u00f6zlerinden ay\u0131rmak i\u00e7in kolon kromatografisini kullanm\u0131\u015ft\u0131r. \u00d6rne\u011fin, Shi Xin ve arkada\u015flar\u0131 Yidianhong t\u0131bbi malzemelerinden > 98.0% safl\u0131kta izoquercitrin ay\u0131rmak i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi kullanm\u0131\u015flard\u0131r; Yin Li 580 mg Huangdingju'dan izoquercitrin elde etmek i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi ile birlikte makrog\u00f6zenekli re\u00e7ine kolon kromatografisi kullanm\u0131\u015ft\u0131r Alkol ekstrakt\u0131ndan 9.3 mg izoquercitrin izole edilmi\u015ftir ve safl\u0131\u011f\u0131 95.8%'dir. Bununla birlikte, bitkilerdeki d\u00fc\u015f\u00fck do\u011fal izoquercitrin i\u00e7eri\u011fi nedeniyle, bu y\u00f6ntem sadece d\u00fc\u015f\u00fck bir verime sahip olmakla kalmaz, ayn\u0131 zamanda b\u00fcy\u00fck bir i\u015f y\u00fck\u00fcne ve \u00e7ok fazla reaktif t\u00fcketimine sahiptir, bu da end\u00fcstriyel uygulamadaki uygulamas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar. Yu Ting ve arkada\u015flar\u0131, izoquercitrin i\u00e7in h\u0131zl\u0131 bir haz\u0131rlama y\u00f6ntemi olu\u015fturmak \u00fczere y\u00fcksek bas\u0131n\u00e7l\u0131 hidrolizi SG64 re\u00e7ine kromatografik ay\u0131rma teknolojisi ile birle\u015ftirmi\u015ftir. Bununla birlikte, hidroliz ko\u015fullar\u0131n\u0131n kontrol edilmesi kolay de\u011fildir ve izoquercitrin verimi d\u00fc\u015f\u00fckt\u00fcr. \u00dcr\u00fcn, daha fazla hidrolizle elde edilen b\u00fcy\u00fck miktarda hidrolize edilmemi\u015f rutin ve kuersetin i\u00e7erir, bu da sonraki ay\u0131rman\u0131n zorlu\u011funu art\u0131r\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nMikrobiyal d\u00f6n\u00fc\u015f\u00fcm ve enzim katalizli d\u00f6n\u00fc\u015f\u00fcm gibi biyoteknoloji, esasen yabanc\u0131 bile\u015fiklerin yap\u0131s\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in serbest enzimler veya kompleks enzimler kullanan metabolik bir reaksiyondur. Hafif ko\u015fullar, g\u00fc\u00e7l\u00fc se\u00e7icilik, az say\u0131da yan \u00fcr\u00fcn, temiz ve \u00e7evre dostu ve d\u00fc\u015f\u00fck maliyet avantajlar\u0131na sahiptir; do\u011fal; Glikozit bile\u015fikleri genellikle daha fazla glikozil grubu i\u00e7erir ve \u00e7ok polard\u0131r, bu nedenle farmakolojik aktivitelerini uygulamak i\u00e7in en iyi yap\u0131 de\u011fildirler. Bunlar\u0131 d\u00fc\u015f\u00fck glikozitlere, aglikonlara veya di\u011fer \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcrmek, etkinliklerini daha iyi g\u00f6stermelerine yard\u0131mc\u0131 olacakt\u0131r. Wang Yuanyuan ve arkada\u015flar\u0131 rutini biyotransforme etmek i\u00e7in Streptomyces griseus kullanm\u0131\u015f ve silika jel kolon kromatografisi ile izoquercitrin dahil 6 d\u00f6n\u00fc\u015f\u00fcm \u00fcr\u00fcn\u00fcn\u00fc ay\u0131rm\u0131\u015flard\u0131r. Daha ileri \u00e7al\u0131\u015fmalar, bu s\u00fcre\u00e7te yer alan reaksiyonlar\u0131n metilasyon ve Glikozit hidrolizi vb. dahil olmak \u00fczere daha karma\u015f\u0131k oldu\u011funu ve Streptomyces griseus'un rutin d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in zay\u0131f \u00f6zg\u00fcll\u00fc\u011fe sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Isoquercitrin bitkilerde d\u00fc\u015f\u00fck bir do\u011fal i\u00e7eri\u011fe sahiptir ve genellikle asit hidrolizi, y\u00fcksek bas\u0131n\u00e7l\u0131 hidroliz ve end\u00fcstrideki di\u011fer y\u00f6ntemlerle haz\u0131rlan\u0131r. \u00c7al\u0131\u015fmalar, izoquercitrin monomerini bitki \u00f6zlerinden ay\u0131rmak i\u00e7in kolon kromatografisini kullanm\u0131\u015ft\u0131r. \u00d6rne\u011fin, Shi Xin ve arkada\u015flar\u0131 Yidianhong t\u0131bbi malzemelerinden > 98.0% safl\u0131kta izoquercitrin ay\u0131rmak i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi kullanm\u0131\u015flard\u0131r; Yin Li 580 mg Huangdingju'dan izoquercitrin elde etmek i\u00e7in yar\u0131 haz\u0131rlay\u0131c\u0131 y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi ile birlikte makrog\u00f6zenekli re\u00e7ine kolon kromatografisi kullanm\u0131\u015ft\u0131r Alkol ekstrakt\u0131ndan 9.3 mg izoquercitrin izole edilmi\u015ftir ve safl\u0131\u011f\u0131 95.8%'dir. Bununla birlikte, bitkilerdeki d\u00fc\u015f\u00fck do\u011fal izoquercitrin i\u00e7eri\u011fi nedeniyle, bu y\u00f6ntem sadece d\u00fc\u015f\u00fck bir verime sahip olmakla kalmaz, ayn\u0131 zamanda b\u00fcy\u00fck bir i\u015f y\u00fck\u00fcne ve \u00e7ok fazla reaktif t\u00fcketimine sahiptir, bu da end\u00fcstriyel uygulamadaki uygulamas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar. Yu Ting ve arkada\u015flar\u0131, izoquercitrin i\u00e7in h\u0131zl\u0131 bir haz\u0131rlama y\u00f6ntemi olu\u015fturmak \u00fczere y\u00fcksek bas\u0131n\u00e7l\u0131 hidrolizi SG64 re\u00e7ine kromatografik ay\u0131rma teknolojisi ile birle\u015ftirmi\u015ftir. Bununla birlikte, hidroliz ko\u015fullar\u0131n\u0131n kontrol edilmesi kolay de\u011fildir ve izoquercitrin verimi d\u00fc\u015f\u00fckt\u00fcr. \u00dcr\u00fcn, daha fazla hidrolizle elde edilen b\u00fcy\u00fck miktarda hidrolize edilmemi\u015f rutin ve kuersetin i\u00e7erir, bu da sonraki ay\u0131rman\u0131n zorlu\u011funu art\u0131r\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nMikrobiyal d\u00f6n\u00fc\u015f\u00fcm ve enzim katalizli d\u00f6n\u00fc\u015f\u00fcm gibi biyoteknoloji, esasen yabanc\u0131 bile\u015fiklerin yap\u0131s\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in serbest enzimler veya kompleks enzimler kullanan metabolik bir reaksiyondur. Hafif ko\u015fullar, g\u00fc\u00e7l\u00fc se\u00e7icilik, az say\u0131da yan \u00fcr\u00fcn, temiz ve \u00e7evre dostu ve d\u00fc\u015f\u00fck maliyet avantajlar\u0131na sahiptir; do\u011fal; Glikozit bile\u015fikleri genellikle daha fazla glikozil grubu i\u00e7erir ve \u00e7ok polard\u0131r, bu nedenle farmakolojik aktivitelerini uygulamak i\u00e7in en iyi yap\u0131 de\u011fildirler. Bunlar\u0131 d\u00fc\u015f\u00fck glikozitlere, aglikonlara veya di\u011fer \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcrmek, etkinliklerini daha iyi g\u00f6stermelerine yard\u0131mc\u0131 olacakt\u0131r. Wang Yuanyuan ve arkada\u015flar\u0131 rutini biyotransforme etmek i\u00e7in Streptomyces griseus kullanm\u0131\u015f ve silika jel kolon kromatografisi ile izoquercitrin dahil 6 d\u00f6n\u00fc\u015f\u00fcm \u00fcr\u00fcn\u00fcn\u00fc ay\u0131rm\u0131\u015flard\u0131r. Daha ileri \u00e7al\u0131\u015fmalar, bu s\u00fcre\u00e7te yer alan reaksiyonlar\u0131n metilasyon ve Glikozit hidrolizi vb. dahil olmak \u00fczere daha karma\u015f\u0131k oldu\u011funu ve Streptomyces griseus'un rutin d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in zay\u0131f \u00f6zg\u00fcll\u00fc\u011fe sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nMikrobiyal d\u00f6n\u00fc\u015f\u00fcm ve enzim katalizli d\u00f6n\u00fc\u015f\u00fcm gibi biyoteknoloji, esasen yabanc\u0131 bile\u015fiklerin yap\u0131s\u0131n\u0131 de\u011fi\u015ftirmek i\u00e7in serbest enzimler veya kompleks enzimler kullanan metabolik bir reaksiyondur. Hafif ko\u015fullar, g\u00fc\u00e7l\u00fc se\u00e7icilik, az say\u0131da yan \u00fcr\u00fcn, temiz ve \u00e7evre dostu ve d\u00fc\u015f\u00fck maliyet avantajlar\u0131na sahiptir; do\u011fal; Glikozit bile\u015fikleri genellikle daha fazla glikozil grubu i\u00e7erir ve \u00e7ok polard\u0131r, bu nedenle farmakolojik aktivitelerini uygulamak i\u00e7in en iyi yap\u0131 de\u011fildirler. Bunlar\u0131 d\u00fc\u015f\u00fck glikozitlere, aglikonlara veya di\u011fer \u00fcr\u00fcnlere d\u00f6n\u00fc\u015ft\u00fcrmek, etkinliklerini daha iyi g\u00f6stermelerine yard\u0131mc\u0131 olacakt\u0131r. Wang Yuanyuan ve arkada\u015flar\u0131 rutini biyotransforme etmek i\u00e7in Streptomyces griseus kullanm\u0131\u015f ve silika jel kolon kromatografisi ile izoquercitrin dahil 6 d\u00f6n\u00fc\u015f\u00fcm \u00fcr\u00fcn\u00fcn\u00fc ay\u0131rm\u0131\u015flard\u0131r. Daha ileri \u00e7al\u0131\u015fmalar, bu s\u00fcre\u00e7te yer alan reaksiyonlar\u0131n metilasyon ve Glikozit hidrolizi vb. dahil olmak \u00fczere daha karma\u015f\u0131k oldu\u011funu ve Streptomyces griseus'un rutin d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u00e7in zay\u0131f \u00f6zg\u00fcll\u00fc\u011fe sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nEnzimatik hidroliz y\u00f6ntemi, hafif reaksiyon ko\u015fullar\u0131, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fck ve reaksiyonun kolay kontrol\u00fc gibi avantajlara sahiptir ve izoquercitrin haz\u0131rlamak i\u00e7in yukar\u0131da belirtilen y\u00f6ntemin eksikliklerinin \u00fcstesinden gelebilir. \u00d6rne\u011fin, Wu Di ve arkada\u015flar\u0131 rutini d\u00f6n\u00fc\u015ft\u00fcrmek i\u00e7in mikroorganizmalar taraf\u0131ndan \u00fcretilen \u03b1-L-rhamnosidaz kullanm\u0131\u015ft\u0131r; sonu\u00e7lar izoquercitrin veriminin 49.4% oldu\u011funu ve silika jel kolon kromatografisi ile safla\u015ft\u0131r\u0131ld\u0131ktan sonra safl\u0131\u011f\u0131n\u0131n 98.3%'ye ula\u015fabilece\u011fini g\u00f6stermi\u015ftir. Sun Guoxia ve arkada\u015flar\u0131 izoquercitrin haz\u0131rlamak \u00fczere rutini hidrolize etmek i\u00e7in hesperidinaz kullanm\u0131\u015f ve izoquercitrin verimini art\u0131rmak i\u00e7in iyonik s\u0131v\u0131lar kullanm\u0131\u015ft\u0131r. Nihai \u00fcr\u00fcn\u00fcn d\u00f6n\u00fc\u015f\u00fcm oran\u0131 99.27 \u00b1 0.55%'ye ula\u015fm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n3. Rutin ve izoquercitrin'in farmakolojik aktivitelerine giri\u015f<\/h3>\r\n\r\n\r\n\r\nRutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Rutin, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 aspir ve di\u011fer ila\u00e7lar\u0131n \u00f6nemli bir bile\u015fenidir. Serebral tromboz ve anjina pektoris gibi kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar \u00fczerinde belirli etkileri vard\u0131r. Jin Ming ve arkada\u015flar\u0131, belirli bir rutin konsantrasyonunun trombosit aktive edici fakt\u00f6r ve tav\u015fan trombosit resept\u00f6rlerinin spesifik ba\u011flanmas\u0131n\u0131 antagonize edebilece\u011fini, b\u00f6ylece aktive edici fakt\u00f6r\u00fcn arac\u0131l\u0131k etti\u011fi trombosit yap\u0131\u015fmas\u0131n\u0131 ve serbest Ca2+<\/sup>\u00a0trombositlerde konsantrasyon.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nGuardia ve arkada\u015flar\u0131 hesperidin, kuersetin ve rutinden olu\u015fan \u00fc\u00e7 flavonoidi ve bu \u00fc\u00e7 flavonoidin s\u0131\u00e7anlar \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir. \u0130lk olarak, bir s\u0131\u00e7an akut ve kronik inflamasyon modeli olu\u015fturulmu\u015ftur. \u00dc\u00e7 flavonoid, 80 mg\/kg-d dozunda intraperitoneal uygulamadan sonra, deneysel inflamasyon modelinin akut ve kronik fazlar\u0131n\u0131 inhibe edebilmektedir; bunlar aras\u0131nda rutin, kronik inflamasyon \u00fczerinde en g\u00fc\u00e7l\u00fc etkiye sahiptir. Yoo ve arkada\u015flar\u0131, rutinin y\u00fcksek hareketlilik grubu proteini 1 (HMGB1) ve ilgili sinyal yollar\u0131 taraf\u0131ndan ind\u00fcklenen insan umbilikal ven endotel h\u00fccrelerinin (HUVEC'ler) pro-enflamatuar yan\u0131t\u0131 \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015ftir. Sonu\u00e7lar rutinin HMGB1 sal\u0131n\u0131m\u0131n\u0131 engelleyebildi\u011fini ve fare l\u00f6kositlerinin g\u00f6\u00e7\u00fcn\u00fc azaltabildi\u011fini g\u00f6stermektedir. Daha ileri \u00e7al\u0131\u015fmalar, rutinin HMGB1 taraf\u0131ndan ind\u00fcklenen t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin 6 \u00fcretimini de inhibe edebilece\u011fini bulmu\u015ftur; bu da rutinin HMGB1 sinyal yolunu inhibe ederek \u00e7e\u015fitli \u015fiddetli vask\u00fclit hastal\u0131klar\u0131n\u0131 tedavi edebilece\u011fini kan\u0131tlamaktad\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nYang ve arkada\u015flar\u0131 rutinin antioksidan aktivitesini \u00f6l\u00e7m\u00fc\u015f ve standart antioksidan olan b\u00fctil hidroksitoluen (BHT) ve askorbik asit (Vc) ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar rutinin DPPH serbest radikallerini temizlemede g\u00fc\u00e7l\u00fc bir yetene\u011fe sahip oldu\u011funu g\u00f6stermektedir. Konsantrasyon 0.05 mg\/mL oldu\u011funda, Vc, BHT ve rutinin inhibisyon oranlar\u0131 s\u0131ras\u0131yla 92.8%, 58.8% ve 90.4%'ye ula\u015fabilir; ayr\u0131ca rutinin lipitler \u00fczerinde g\u00fc\u00e7l\u00fc bir etkisi vard\u0131r. Kalitatif peroksidasyon da \u00f6nemli bir inhibit\u00f6r etkiye sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro ve arkada\u015flar\u0131, rutinin insan kanser h\u00fccreleri ve t\u00fcm\u00f6rijenik olmayan h\u00fccre hatlar\u0131 \u00fczerindeki sitotoksik etkisini tespit etmek i\u00e7in MTT y\u00f6ntemini kullanm\u0131\u015flard\u0131r. Farkl\u0131 rutin dozlar\u0131 32 g\u00fcn boyunca SW480 kolon karsinomlu nu\/nu farelere intraperitoneal olarak enjekte edilmi\u015f; serum vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF) seviyeleri, hayatta kalma s\u00fcresi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve organlar\u0131n a\u011f\u0131rl\u0131\u011f\u0131 \u00fczerindeki toksikolojik etkiler analiz edilmi\u015ftir. Sonu\u00e7lar, rutinin SW480 h\u00fccreleri \u00fczerinde en y\u00fcksek sitotoksik etkiye sahip oldu\u011funu (IC50 = 125 \u03bcM) ve farelerin di\u011fer organlar\u0131 \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; tedavi edilmeyen farelerle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, ortalama hayatta kalma s\u00fcresi 50 g\u00fcn uzar ve serum VEGF seviyesi 55% azal\u0131r. Saleh ve arkada\u015flar\u0131 rutin ve orlistat\u0131n iki meme kanseri modeli (in vivo EAC ve in vitro MCF7) ve pankreas kanseri h\u00fccre hatlar\u0131 (PANC-1) \u00fczerindeki antikanser etkilerini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. T\u00fcm\u00f6r hacmi, CEA (karsinoembriyonik antijen) seviyesi, kolesterol i\u00e7eri\u011fi, FAS antijeni, antioksidan etki ve histopatolojik inceleme, hem rutin hem de orlistat\u0131n v\u00fccutta anti-kanser aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ayr\u0131ca, her ikisi de apoptozu te\u015fvik ederek MCF-7 ve PANC-1 h\u00fccre hatlar\u0131 i\u00e7in sitotoksiktir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nModern farmakolojik \u00e7al\u0131\u015fmalar, izoquercitrinin anti-oksidasyon, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerdeki farmakolojik aktivitelerinin rutinden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Jung ve arkada\u015flar\u0131 Platycladus orientalis'ten isoquercitrin gibi yedi bile\u015fik izole etmi\u015f ve antioksidan aktivitelerini test etmi\u015flerdir. Sonu\u00e7lar, isoquercitrin'in hidrojen peroksitle ind\u00fcklenen retinal ganglion h\u00fccre hatt\u0131 RGC-5 \u00fczerinde etkili oldu\u011funu g\u00f6stermi\u015ftir (H2<\/sub>O2<\/sub>). H\u00fccre \u00f6l\u00fcm\u00fcn\u00fc engelleyici etkisi en g\u00fc\u00e7l\u00fc olan\u0131d\u0131r. Ayn\u0131 zamanda, izoquercitrin oral olarak tolere edilir, bu nedenle glokom gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131labilir. Rogerio ve arkada\u015flar\u0131, quercetin ve isoquercitrin'in ast\u0131m fare modelleri \u00fczerindeki anti-enflamatuar etkilerini incelemi\u015flerdir; sonu\u00e7lar, bu iki flavonoidin etkili eozinofilik enflamasyon inhibit\u00f6rleri oldu\u011funu ve alerjik hastal\u0131klar\u0131n tedavisi i\u00e7in belirli bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nHuang ve arkada\u015flar\u0131 izoquercitrinin karaci\u011fer kanseri \u00fczerindeki etki mekanizmas\u0131n\u0131 incelemi\u015flerdir. In vitro deneylerde, isoquercitrin'in apoptozu te\u015fvik ederken kanser h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleyebildi\u011fi ve ayn\u0131 zamanda insan karaci\u011fer kanseri h\u00fccrelerinde PKC'nin ekspresyon seviyesini azaltabildi\u011fi bulunmu\u015ftur; in vivo deneylerde, isoquercitrin \u00e7\u0131plak farelerde nakledilen t\u00fcm\u00f6rlere de neden olabilir. H\u00fccrelerin b\u00fcy\u00fcme oran\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131r. \u0130zoquercitrin'in karaci\u011fer kanserinin olu\u015fumunu ve geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilece\u011fi ve molek\u00fcler mekanizmas\u0131n\u0131n PKC ve MAPK sinyal yollar\u0131yla ilgili olabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nJi Lili, Moringa oleifera yapraklar\u0131n\u0131n izoquercitrin ve toplam flavonoidlerinin in vitro hipoglisemik aktivitesini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. Sonu\u00e7lar, her ikisinin de HepG2 h\u00fccreleri taraf\u0131ndan glikoz t\u00fcketimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve isoquercitrin'in hipoglisemik etkisinin toplam flavonoidlerden \u00f6nemli \u00f6l\u00e7\u00fcde daha g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermektedir; daha ileri \u00e7al\u0131\u015fmalar, hipoglisemik mekanizmas\u0131n\u0131n esas olarak DPP-4 aktivitesini inhibe ederek artt\u0131\u011f\u0131n\u0131 ve ins\u00fclin salg\u0131lanmas\u0131n\u0131n da InsR, PKA ve PKC\u03b1 ekspresyonunu yukar\u0131 reg\u00fcle etti\u011fini, b\u00f6ylece ins\u00fclinin etkisini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer ve pankreas adac\u0131k h\u00fccrelerinin proliferasyonunu te\u015fvik etti\u011fini bulmu\u015ftur.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nYun ve arkada\u015flar\u0131 isoquercitrin'in antifungal aktivitesini ve etki mekanizmas\u0131n\u0131 tart\u0131\u015fm\u0131\u015f; sonu\u00e7lar isoquercitrin'in patojenik mantarlar\u0131n duyarl\u0131l\u0131k testinde g\u00fc\u00e7l\u00fc bir etkiye sahip oldu\u011funu ve hemoliz bulunmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, candida albicans da malonil iyod\u00fcr ve potasyum sal\u0131n\u0131m\u0131 i\u00e7in test edilmi\u015f ve izoquercitrinin h\u00fccre zar\u0131na m\u00fcdahale edebilece\u011fi ve membran hasar\u0131n\u0131 te\u015fvik etmek i\u00e7in ge\u00e7irgenli\u011fini art\u0131rabilece\u011fi ve b\u00f6ylece antibakteriyel aktivite uygulayabilece\u011fi do\u011frulanm\u0131\u015ft\u0131r. Kim ve arkada\u015flar\u0131, isoquercitrin'in influenza A ve B vir\u00fcslerinin replikasyonunu inhibe edebilece\u011fini ve amantadin ve oseltamivir ile birlikte kullan\u0131ld\u0131\u011f\u0131nda, diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini ve isoquercitrin'in diren\u00e7li vir\u00fcslerin ortaya \u00e7\u0131kmas\u0131n\u0131 etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6sterdi\u011fini bulmu\u015flard\u0131r. Viral influenza tedavisi i\u00e7in belirli bir uygulama potansiyeline sahiptir.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\nFiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nBile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nKsilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nSel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nAlfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/figure>\r\n\r\n\r\n\r\nYukar\u0131daki etkilere ek olarak, izoquercitrin ayr\u0131ca anti-osteoporoz, kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcrme, kan lipitleri, n\u00f6roproteksiyon ve anti-depresyon gibi fizyolojik aktivitelere de sahiptir. Rutinin biyotransformasyonunda \u03b1-L-rhamnosidaz uygulamas\u0131 daha sonra tan\u0131t\u0131lacakt\u0131r.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
- \n
- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n
- \n
- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\n\u015eimdi Bize Ula\u015f\u0131n!<\/b><\/strong><\/h2>\r\n
Fiyata ihtiyac\u0131n\u0131z varsa, l\u00fctfen a\u015fa\u011f\u0131daki forma ileti\u015fim bilgilerinizi doldurun, genellikle 24 saat i\u00e7inde sizinle ileti\u015fime ge\u00e7ece\u011fiz. Bana e-posta da g\u00f6nderebilirsiniz\u00a0info@longchangchemical.com<\/a><\/span>\u00a0\u00c7al\u0131\u015fma saatleri i\u00e7inde (8:30 - 6:00 UTC+8 Pzt.~Sat.) veya h\u0131zl\u0131 yan\u0131t almak i\u00e7in web sitesi canl\u0131 sohbetini kullan\u0131n.<\/b><\/strong><\/h4>\r\n
\r\n\r\n
\r\n Bile\u015fik Glukoamilaz<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\n Pullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\n Ksilanaz<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\n Sel\u00fclaz<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\n Naringinaz<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n \u03b2-Amilaz<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\n Glikoz oksidaz<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\n Alfa-Amilaz<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\n Pektinaz<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\n Peroksidaz<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\n Lipaz<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\n Katalaz<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\n TANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\n Elastaz<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\n Urease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\n DEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\n L-Laktik dehidrojenaz<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\n Dehidrojenaz malat<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\n Kolesterol oksidaz<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":" 1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"description\":\"We hope our products are used worldwide to enable science.\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"tr_TR","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/tr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"tr","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"Rutin ve izoquercitrinin haz\u0131rlanmas\u0131 ve farmakolojik aktivitesi - Longchang Chemical","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","description":"\u00dcr\u00fcnlerimizin d\u00fcnya \u00e7ap\u0131nda bilimi m\u00fcmk\u00fcn k\u0131lmak i\u00e7in kullan\u0131lmas\u0131n\u0131 umuyoruz.","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Preparation and pharmacological activity of rutin and isoquercitrin"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Longchang Kimya","description":"\u00c7in kimyasal \u00fcreticisi \uff06 tedarik\u00e7isi","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Longchang Kimya","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Longchang Kimya","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/tr\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/comments?post=4452"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions"}],"predecessor-version":[{"id":9094,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/posts\/4452\/revisions\/9094"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/media?parent=4452"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/categories?post=4452"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/tr\/wp-json\/wp\/v2\/tags?post=4452"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}} - CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n