A rutina, tamb\u00e9m conhecida como vitamina P, tem a f\u00f3rmula molecular C27<\/sub>H30<\/sub>O16<\/sub>. A estrutura qu\u00edmica da rutina \u00e9 mostrada na Figura 1. \u00c9 um glicos\u00eddeo flavonoide natural com efeitos anti-inflamat\u00f3rios, antioxidantes, antial\u00e9rgicos e antivirais. O ponto de fus\u00e3o da rutina \u00e9 de aproximadamente 178 \u2103 e ela \u00e9 um cristal amarelo em temperatura ambiente. Sua cor fica mais escura quando exposta \u00e0 luz e tem um sabor amargo. Tem baixa solubilidade em \u00e1gua, \u00e9 facilmente sol\u00favel em metanol e etanol e insol\u00favel em reagentes org\u00e2nicos com baixa polaridade, como \u00e9ter de petr\u00f3leo. A rutina \u00e9 amplamente encontrada nas ra\u00edzes, caules, folhas e outras partes das plantas, e seu conte\u00fado \u00e9 maior em plantas como Sophora japonicus, erva rutinosa, Eclipta prostrata e trigo sarraceno. Atualmente, a rutina \u00e9 extra\u00edda principalmente da Sophora japonica na produ\u00e7\u00e3o industrial, e seu conte\u00fado pode chegar a mais de 23,0%. Em termos de distribui\u00e7\u00e3o geogr\u00e1fica, o teor de rutina na Sophora japonica \u00e9 maior nas prov\u00edncias de Henan, Shandong e Hebei. Al\u00e9m disso, alguns estudos mostraram que o trigo sarraceno, as t\u00e2maras vermelhas, as folhas de amoreira e outras plantas tamb\u00e9m cont\u00eam uma certa quantidade de rutina.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\")
<\/figure>\r\n\r\n\r\n\r\nFigura 1 A estrutura qu\u00edmica da rutina<\/h5>\r\n\r\n\r\n\r\nA isoquercitrina, tamb\u00e9m conhecida como apocynum A, \u00e9 um derivado da rutina derivado do derhamnosil. Sua f\u00f3rmula molecular \u00e9 C21<\/sub>H20<\/sub>O12<\/sub>. A estrutura qu\u00edmica da isoquercitrina \u00e9 mostrada na Figura 2. A isoquercitrina tem um ponto de fus\u00e3o de aproximadamente 226 \u00b0C e \u00e9 um cristal amarelo em temperatura ambiente. Sua solubilidade em \u00e1gua \u00e9 baixa, apenas 25,9 mg\/L em temperatura ambiente. Ela se torna mais escura ap\u00f3s ser dissolvida em \u00e1gua alcalina. A isoquercitrina \u00e9 amplamente distribu\u00edda em plantas, incluindo Saururus chinensis, Houttuynia cordata, Rhododendron gold leaf, rododendro, Ginkgo biloba, Morus mulberry e Elaeagnus seabuckthorn, etc. No entanto, o conte\u00fado natural de isoquercitrina nas plantas \u00e9 baixo, apenas alguns dez mil\u00e9simos em m\u00e9dia, por isso ela \u00e9 preparada principalmente por m\u00e9todos sint\u00e9ticos. Estudos farmacol\u00f3gicos modernos demonstraram que a atividade farmacol\u00f3gica da isoquercitrina \u00e9 significativamente maior do que a da rutina, e seu valor medicinal \u00e9 maior.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-2.png\")
<\/figure>\r\n\r\n\r\n\r\nFigura 2 A estrutura qu\u00edmica da isoquercitrina<\/h5>\r\n\r\n\r\n\r\n2. Prepara\u00e7\u00e3o da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA isoquercitrina tem um baixo teor natural nas plantas e \u00e9 frequentemente preparada por hidr\u00f3lise \u00e1cida, hidr\u00f3lise de alta press\u00e3o e outros m\u00e9todos no setor. Estudos usaram a cromatografia em coluna para separar o mon\u00f4mero de isoquercitrina dos extratos vegetais. Por exemplo, Shi Xin et al. usaram a cromatografia l\u00edquida de alto desempenho semipreparativa para separar a isoquercitrina com uma pureza > 98,0% dos materiais medicinais de Yidianhong; Yin Li usou a cromatografia em coluna de resina macroporosa combinada com a cromatografia l\u00edquida de alto desempenho semipreparativa para obter a isoquercitrina de 580 mg de Huangdingju 9,3 mg de isoquercitrina foram isolados do extrato alco\u00f3lico, e sua pureza foi de 95,8%. No entanto, devido ao baixo teor natural de isoquercitrina nas plantas, esse m\u00e9todo n\u00e3o s\u00f3 tem um baixo rendimento, mas tamb\u00e9m tem uma grande carga de trabalho e um grande consumo de reagentes, o que limita muito sua aplica\u00e7\u00e3o na pr\u00e1tica industrial. Yu Ting et al. combinaram a hidr\u00f3lise de alta press\u00e3o com a tecnologia de separa\u00e7\u00e3o cromatogr\u00e1fica de resina SG64 para estabelecer um m\u00e9todo de prepara\u00e7\u00e3o r\u00e1pida para a isoquercitrina. No entanto, as condi\u00e7\u00f5es de hidr\u00f3lise n\u00e3o s\u00e3o f\u00e1ceis de controlar, e o rendimento da isoquercitrina \u00e9 baixo. O produto cont\u00e9m uma grande quantidade de rutina e quercetina n\u00e3o hidrolisadas obtidas por hidr\u00f3lise adicional, o que aumenta a dificuldade da separa\u00e7\u00e3o subsequente.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-1.png\")
<\/figure>\r\n\r\n\r\n\r\nA biotecnologia, como a transforma\u00e7\u00e3o microbiana e a transforma\u00e7\u00e3o catalisada por enzimas, \u00e9 essencialmente uma rea\u00e7\u00e3o metab\u00f3lica que usa enzimas livres ou enzimas complexas para modificar a estrutura de compostos estranhos. Ela tem as vantagens de condi\u00e7\u00f5es brandas, alta seletividade, poucos subprodutos, limpeza, respeito ao meio ambiente e baixo custo; natural; os compostos de glicos\u00eddeos geralmente cont\u00eam mais grupos glicosil e s\u00e3o muito polares, portanto, n\u00e3o s\u00e3o a melhor estrutura para exercer sua atividade farmacol\u00f3gica. Convert\u00ea-los em glicos\u00eddeos baixos, agliconas ou outros produtos ajudar\u00e1 a exercer melhor sua efic\u00e1cia. Wang Yuanyuan et al. usaram Streptomyces griseus para biotransformar a rutina e separaram seis produtos de convers\u00e3o, incluindo a isoquercitrina, por cromatografia em coluna de s\u00edlica gel. Estudos posteriores descobriram que as rea\u00e7\u00f5es envolvidas nesse processo s\u00e3o mais complicadas, incluindo metila\u00e7\u00e3o e hidr\u00f3lise de glicos\u00eddeos, etc., indicando que o Streptomyces griseus tem pouca especificidade para a transforma\u00e7\u00e3o da rutina.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter.png\")
<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-2.png\")
<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nFigura 1 A estrutura qu\u00edmica da rutina<\/h5>\r\n\r\n\r\n\r\nA isoquercitrina, tamb\u00e9m conhecida como apocynum A, \u00e9 um derivado da rutina derivado do derhamnosil. Sua f\u00f3rmula molecular \u00e9 C21<\/sub>H20<\/sub>O12<\/sub>. A estrutura qu\u00edmica da isoquercitrina \u00e9 mostrada na Figura 2. A isoquercitrina tem um ponto de fus\u00e3o de aproximadamente 226 \u00b0C e \u00e9 um cristal amarelo em temperatura ambiente. Sua solubilidade em \u00e1gua \u00e9 baixa, apenas 25,9 mg\/L em temperatura ambiente. Ela se torna mais escura ap\u00f3s ser dissolvida em \u00e1gua alcalina. A isoquercitrina \u00e9 amplamente distribu\u00edda em plantas, incluindo Saururus chinensis, Houttuynia cordata, Rhododendron gold leaf, rododendro, Ginkgo biloba, Morus mulberry e Elaeagnus seabuckthorn, etc. No entanto, o conte\u00fado natural de isoquercitrina nas plantas \u00e9 baixo, apenas alguns dez mil\u00e9simos em m\u00e9dia, por isso ela \u00e9 preparada principalmente por m\u00e9todos sint\u00e9ticos. Estudos farmacol\u00f3gicos modernos demonstraram que a atividade farmacol\u00f3gica da isoquercitrina \u00e9 significativamente maior do que a da rutina, e seu valor medicinal \u00e9 maior.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nFigura 2 A estrutura qu\u00edmica da isoquercitrina<\/h5>\r\n\r\n\r\n\r\n2. Prepara\u00e7\u00e3o da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA isoquercitrina tem um baixo teor natural nas plantas e \u00e9 frequentemente preparada por hidr\u00f3lise \u00e1cida, hidr\u00f3lise de alta press\u00e3o e outros m\u00e9todos no setor. Estudos usaram a cromatografia em coluna para separar o mon\u00f4mero de isoquercitrina dos extratos vegetais. Por exemplo, Shi Xin et al. usaram a cromatografia l\u00edquida de alto desempenho semipreparativa para separar a isoquercitrina com uma pureza > 98,0% dos materiais medicinais de Yidianhong; Yin Li usou a cromatografia em coluna de resina macroporosa combinada com a cromatografia l\u00edquida de alto desempenho semipreparativa para obter a isoquercitrina de 580 mg de Huangdingju 9,3 mg de isoquercitrina foram isolados do extrato alco\u00f3lico, e sua pureza foi de 95,8%. No entanto, devido ao baixo teor natural de isoquercitrina nas plantas, esse m\u00e9todo n\u00e3o s\u00f3 tem um baixo rendimento, mas tamb\u00e9m tem uma grande carga de trabalho e um grande consumo de reagentes, o que limita muito sua aplica\u00e7\u00e3o na pr\u00e1tica industrial. Yu Ting et al. combinaram a hidr\u00f3lise de alta press\u00e3o com a tecnologia de separa\u00e7\u00e3o cromatogr\u00e1fica de resina SG64 para estabelecer um m\u00e9todo de prepara\u00e7\u00e3o r\u00e1pida para a isoquercitrina. No entanto, as condi\u00e7\u00f5es de hidr\u00f3lise n\u00e3o s\u00e3o f\u00e1ceis de controlar, e o rendimento da isoquercitrina \u00e9 baixo. O produto cont\u00e9m uma grande quantidade de rutina e quercetina n\u00e3o hidrolisadas obtidas por hidr\u00f3lise adicional, o que aumenta a dificuldade da separa\u00e7\u00e3o subsequente.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotecnologia, como a transforma\u00e7\u00e3o microbiana e a transforma\u00e7\u00e3o catalisada por enzimas, \u00e9 essencialmente uma rea\u00e7\u00e3o metab\u00f3lica que usa enzimas livres ou enzimas complexas para modificar a estrutura de compostos estranhos. Ela tem as vantagens de condi\u00e7\u00f5es brandas, alta seletividade, poucos subprodutos, limpeza, respeito ao meio ambiente e baixo custo; natural; os compostos de glicos\u00eddeos geralmente cont\u00eam mais grupos glicosil e s\u00e3o muito polares, portanto, n\u00e3o s\u00e3o a melhor estrutura para exercer sua atividade farmacol\u00f3gica. Convert\u00ea-los em glicos\u00eddeos baixos, agliconas ou outros produtos ajudar\u00e1 a exercer melhor sua efic\u00e1cia. Wang Yuanyuan et al. usaram Streptomyces griseus para biotransformar a rutina e separaram seis produtos de convers\u00e3o, incluindo a isoquercitrina, por cromatografia em coluna de s\u00edlica gel. Estudos posteriores descobriram que as rea\u00e7\u00f5es envolvidas nesse processo s\u00e3o mais complicadas, incluindo metila\u00e7\u00e3o e hidr\u00f3lise de glicos\u00eddeos, etc., indicando que o Streptomyces griseus tem pouca especificidade para a transforma\u00e7\u00e3o da rutina.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nFigura 2 A estrutura qu\u00edmica da isoquercitrina<\/h5>\r\n\r\n\r\n\r\n2. Prepara\u00e7\u00e3o da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA isoquercitrina tem um baixo teor natural nas plantas e \u00e9 frequentemente preparada por hidr\u00f3lise \u00e1cida, hidr\u00f3lise de alta press\u00e3o e outros m\u00e9todos no setor. Estudos usaram a cromatografia em coluna para separar o mon\u00f4mero de isoquercitrina dos extratos vegetais. Por exemplo, Shi Xin et al. usaram a cromatografia l\u00edquida de alto desempenho semipreparativa para separar a isoquercitrina com uma pureza > 98,0% dos materiais medicinais de Yidianhong; Yin Li usou a cromatografia em coluna de resina macroporosa combinada com a cromatografia l\u00edquida de alto desempenho semipreparativa para obter a isoquercitrina de 580 mg de Huangdingju 9,3 mg de isoquercitrina foram isolados do extrato alco\u00f3lico, e sua pureza foi de 95,8%. No entanto, devido ao baixo teor natural de isoquercitrina nas plantas, esse m\u00e9todo n\u00e3o s\u00f3 tem um baixo rendimento, mas tamb\u00e9m tem uma grande carga de trabalho e um grande consumo de reagentes, o que limita muito sua aplica\u00e7\u00e3o na pr\u00e1tica industrial. Yu Ting et al. combinaram a hidr\u00f3lise de alta press\u00e3o com a tecnologia de separa\u00e7\u00e3o cromatogr\u00e1fica de resina SG64 para estabelecer um m\u00e9todo de prepara\u00e7\u00e3o r\u00e1pida para a isoquercitrina. No entanto, as condi\u00e7\u00f5es de hidr\u00f3lise n\u00e3o s\u00e3o f\u00e1ceis de controlar, e o rendimento da isoquercitrina \u00e9 baixo. O produto cont\u00e9m uma grande quantidade de rutina e quercetina n\u00e3o hidrolisadas obtidas por hidr\u00f3lise adicional, o que aumenta a dificuldade da separa\u00e7\u00e3o subsequente.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotecnologia, como a transforma\u00e7\u00e3o microbiana e a transforma\u00e7\u00e3o catalisada por enzimas, \u00e9 essencialmente uma rea\u00e7\u00e3o metab\u00f3lica que usa enzimas livres ou enzimas complexas para modificar a estrutura de compostos estranhos. Ela tem as vantagens de condi\u00e7\u00f5es brandas, alta seletividade, poucos subprodutos, limpeza, respeito ao meio ambiente e baixo custo; natural; os compostos de glicos\u00eddeos geralmente cont\u00eam mais grupos glicosil e s\u00e3o muito polares, portanto, n\u00e3o s\u00e3o a melhor estrutura para exercer sua atividade farmacol\u00f3gica. Convert\u00ea-los em glicos\u00eddeos baixos, agliconas ou outros produtos ajudar\u00e1 a exercer melhor sua efic\u00e1cia. Wang Yuanyuan et al. usaram Streptomyces griseus para biotransformar a rutina e separaram seis produtos de convers\u00e3o, incluindo a isoquercitrina, por cromatografia em coluna de s\u00edlica gel. Estudos posteriores descobriram que as rea\u00e7\u00f5es envolvidas nesse processo s\u00e3o mais complicadas, incluindo metila\u00e7\u00e3o e hidr\u00f3lise de glicos\u00eddeos, etc., indicando que o Streptomyces griseus tem pouca especificidade para a transforma\u00e7\u00e3o da rutina.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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A isoquercitrina tem um baixo teor natural nas plantas e \u00e9 frequentemente preparada por hidr\u00f3lise \u00e1cida, hidr\u00f3lise de alta press\u00e3o e outros m\u00e9todos no setor. Estudos usaram a cromatografia em coluna para separar o mon\u00f4mero de isoquercitrina dos extratos vegetais. Por exemplo, Shi Xin et al. usaram a cromatografia l\u00edquida de alto desempenho semipreparativa para separar a isoquercitrina com uma pureza > 98,0% dos materiais medicinais de Yidianhong; Yin Li usou a cromatografia em coluna de resina macroporosa combinada com a cromatografia l\u00edquida de alto desempenho semipreparativa para obter a isoquercitrina de 580 mg de Huangdingju 9,3 mg de isoquercitrina foram isolados do extrato alco\u00f3lico, e sua pureza foi de 95,8%. No entanto, devido ao baixo teor natural de isoquercitrina nas plantas, esse m\u00e9todo n\u00e3o s\u00f3 tem um baixo rendimento, mas tamb\u00e9m tem uma grande carga de trabalho e um grande consumo de reagentes, o que limita muito sua aplica\u00e7\u00e3o na pr\u00e1tica industrial. Yu Ting et al. combinaram a hidr\u00f3lise de alta press\u00e3o com a tecnologia de separa\u00e7\u00e3o cromatogr\u00e1fica de resina SG64 para estabelecer um m\u00e9todo de prepara\u00e7\u00e3o r\u00e1pida para a isoquercitrina. No entanto, as condi\u00e7\u00f5es de hidr\u00f3lise n\u00e3o s\u00e3o f\u00e1ceis de controlar, e o rendimento da isoquercitrina \u00e9 baixo. O produto cont\u00e9m uma grande quantidade de rutina e quercetina n\u00e3o hidrolisadas obtidas por hidr\u00f3lise adicional, o que aumenta a dificuldade da separa\u00e7\u00e3o subsequente.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotecnologia, como a transforma\u00e7\u00e3o microbiana e a transforma\u00e7\u00e3o catalisada por enzimas, \u00e9 essencialmente uma rea\u00e7\u00e3o metab\u00f3lica que usa enzimas livres ou enzimas complexas para modificar a estrutura de compostos estranhos. Ela tem as vantagens de condi\u00e7\u00f5es brandas, alta seletividade, poucos subprodutos, limpeza, respeito ao meio ambiente e baixo custo; natural; os compostos de glicos\u00eddeos geralmente cont\u00eam mais grupos glicosil e s\u00e3o muito polares, portanto, n\u00e3o s\u00e3o a melhor estrutura para exercer sua atividade farmacol\u00f3gica. Convert\u00ea-los em glicos\u00eddeos baixos, agliconas ou outros produtos ajudar\u00e1 a exercer melhor sua efic\u00e1cia. Wang Yuanyuan et al. usaram Streptomyces griseus para biotransformar a rutina e separaram seis produtos de convers\u00e3o, incluindo a isoquercitrina, por cromatografia em coluna de s\u00edlica gel. Estudos posteriores descobriram que as rea\u00e7\u00f5es envolvidas nesse processo s\u00e3o mais complicadas, incluindo metila\u00e7\u00e3o e hidr\u00f3lise de glicos\u00eddeos, etc., indicando que o Streptomyces griseus tem pouca especificidade para a transforma\u00e7\u00e3o da rutina.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nA biotecnologia, como a transforma\u00e7\u00e3o microbiana e a transforma\u00e7\u00e3o catalisada por enzimas, \u00e9 essencialmente uma rea\u00e7\u00e3o metab\u00f3lica que usa enzimas livres ou enzimas complexas para modificar a estrutura de compostos estranhos. Ela tem as vantagens de condi\u00e7\u00f5es brandas, alta seletividade, poucos subprodutos, limpeza, respeito ao meio ambiente e baixo custo; natural; os compostos de glicos\u00eddeos geralmente cont\u00eam mais grupos glicosil e s\u00e3o muito polares, portanto, n\u00e3o s\u00e3o a melhor estrutura para exercer sua atividade farmacol\u00f3gica. Convert\u00ea-los em glicos\u00eddeos baixos, agliconas ou outros produtos ajudar\u00e1 a exercer melhor sua efic\u00e1cia. Wang Yuanyuan et al. usaram Streptomyces griseus para biotransformar a rutina e separaram seis produtos de convers\u00e3o, incluindo a isoquercitrina, por cromatografia em coluna de s\u00edlica gel. Estudos posteriores descobriram que as rea\u00e7\u00f5es envolvidas nesse processo s\u00e3o mais complicadas, incluindo metila\u00e7\u00e3o e hidr\u00f3lise de glicos\u00eddeos, etc., indicando que o Streptomyces griseus tem pouca especificidade para a transforma\u00e7\u00e3o da rutina.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nO m\u00e9todo de hidr\u00f3lise enzim\u00e1tica tem as vantagens de condi\u00e7\u00f5es de rea\u00e7\u00e3o brandas, forte especificidade e f\u00e1cil controle da rea\u00e7\u00e3o, e pode superar as defici\u00eancias do m\u00e9todo mencionado acima para preparar a isoquercitrina. Por exemplo, Wu Di et al. usaram a \u03b1-L-rhamnosidase produzida por microrganismos para transformar a rutina; os resultados mostraram que o rendimento da isoquercitrina foi de 49,4%, e sua pureza pode chegar a 98,3% ap\u00f3s a purifica\u00e7\u00e3o por cromatografia em coluna de s\u00edlica gel. Sun Guoxia et al. usaram a hesperidinase para hidrolisar a rutina e preparar a isoquercitrina, e usaram l\u00edquidos i\u00f4nicos para aumentar o rendimento da isoquercitrina. A taxa de convers\u00e3o do produto final atingiu 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introdu\u00e7\u00e3o \u00e0s atividades farmacol\u00f3gicas da rutina e da isoquercitrina<\/h3>\r\n\r\n\r\n\r\nA rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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A rutina \u00e9 um componente importante do c\u00e1rtamo da medicina tradicional chinesa e de outros medicamentos para promover a circula\u00e7\u00e3o sangu\u00ednea e remover a estagna\u00e7\u00e3o do sangue. Ela tem certos efeitos sobre doen\u00e7as cardiovasculares e cerebrovasculares, como trombose cerebral e angina pectoris. Jin Ming et al. descobriram que uma determinada concentra\u00e7\u00e3o de rutina pode antagonizar a liga\u00e7\u00e3o espec\u00edfica do fator ativador de plaquetas e dos receptores de plaquetas de coelho, inibindo assim a ades\u00e3o plaquet\u00e1ria mediada pelo fator ativador e o aumento de Ca2+<\/sup>\u00a0nas plaquetas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nGuardia et al. estudaram tr\u00eas flavonoides: hesperidina, quercetina e rutina, e os efeitos da a\u00e7\u00e3o anti-inflamat\u00f3ria desses tr\u00eas flavonoides em ratos. Primeiro, foi constru\u00eddo um modelo de inflama\u00e7\u00e3o aguda e cr\u00f4nica em ratos. Ap\u00f3s a administra\u00e7\u00e3o intraperitoneal em uma dose de 80 mg\/kg-d, os tr\u00eas flavonoides podem inibir as fases aguda e cr\u00f4nica do modelo de inflama\u00e7\u00e3o experimental; entre eles, a rutina tem o efeito mais forte na inflama\u00e7\u00e3o cr\u00f4nica. Yoo et al. estudaram os efeitos anti-inflamat\u00f3rios da rutina sobre a resposta pr\u00f3-inflamat\u00f3ria das c\u00e9lulas endoteliais da veia umbilical humana (HUVECs) induzidas pela prote\u00edna 1 do grupo de alta mobilidade (HMGB1) e vias de sinaliza\u00e7\u00e3o relacionadas. Os resultados mostram que a rutina pode inibir a libera\u00e7\u00e3o de HMGB1 e reduzir a migra\u00e7\u00e3o de leuc\u00f3citos de camundongos. Outros estudos descobriram que a rutina tamb\u00e9m pode inibir a produ\u00e7\u00e3o do fator de necrose tumoral alfa e da interleucina 6 induzida pela HMGB1, o que prova que a rutina pode tratar v\u00e1rias doen\u00e7as graves de vasculite inibindo a via de sinaliza\u00e7\u00e3o da HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nYang et al. mediram a atividade antioxidante da rutina e a compararam com o antioxidante padr\u00e3o butil-hidroxitolueno (BHT) e o \u00e1cido asc\u00f3rbico (Vc). Os resultados mostram que a rutina tem uma forte capacidade de eliminar os radicais livres DPPH. Quando a concentra\u00e7\u00e3o \u00e9 de 0,05 mg\/mL, as taxas de inibi\u00e7\u00e3o de Vc, BHT e rutina podem chegar a 92,8%, 58,8% e 90,4%, respectivamente; al\u00e9m disso, a rutina tem um forte efeito sobre os lip\u00eddios. A peroxida\u00e7\u00e3o qualitativa tamb\u00e9m tem um efeito inibit\u00f3rio significativo.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. usaram o m\u00e9todo MTT para detectar o efeito citot\u00f3xico da rutina em c\u00e9lulas de c\u00e2ncer humano e linhas de c\u00e9lulas n\u00e3o tumorig\u00eanicas. Diferentes doses de rutina foram injetadas intraperitonealmente em camundongos nu\/nu com carcinoma de c\u00f3lon SW480 por 32 dias; os n\u00edveis s\u00e9ricos do fator de crescimento endotelial vascular (VEGF), o tempo de sobreviv\u00eancia e os efeitos toxicol\u00f3gicos sobre o peso corporal e o peso dos \u00f3rg\u00e3os foram analisados. Os resultados mostram que a rutina tem o maior efeito citot\u00f3xico nas c\u00e9lulas SW480 (IC50 = 125 \u03bcM) e n\u00e3o tem efeito t\u00f3xico em outros \u00f3rg\u00e3os dos camundongos; em compara\u00e7\u00e3o com os camundongos n\u00e3o tratados, o tempo m\u00e9dio de sobreviv\u00eancia \u00e9 prolongado em 50 dias e o n\u00edvel s\u00e9rico de VEGF A diminui de 55%. Saleh et al. compararam os efeitos anticancer\u00edgenos da rutina e do orlistat em dois modelos de c\u00e2ncer de mama (EAC in vivo e MCF7 in vitro) e em linhas celulares de c\u00e2ncer pancre\u00e1tico (PANC-1). O volume do tumor, o n\u00edvel de CEA (ant\u00edgeno carcinoembrion\u00e1rio), o conte\u00fado de colesterol, o ant\u00edgeno FAS, o efeito antioxidante e o exame histopatol\u00f3gico mostraram que tanto a rutina quanto o orlistat tinham atividade anticancer\u00edgena no organismo. Al\u00e9m disso, ambos s\u00e3o citot\u00f3xicos para as linhas celulares MCF-7 e PANC-1, promovendo a apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nEstudos farmacol\u00f3gicos modernos mostraram que as atividades farmacol\u00f3gicas da isoquercitrina na antioxida\u00e7\u00e3o, antitumor e outros aspectos s\u00e3o significativamente maiores do que as da rutina. Jung et al. isolaram sete compostos, como a isoquercitrina, do Platycladus orientalis e testaram sua atividade antioxidante. Os resultados mostraram que a isoquercitrina tem um efeito sobre a linha de c\u00e9lulas ganglionares da retina RGC-5 induzida por per\u00f3xido de hidrog\u00eanio (H2<\/sub>O2<\/sub>). O efeito inibit\u00f3rio da morte celular \u00e9 o mais forte. Ao mesmo tempo, a isoquercitrina \u00e9 tolerada por via oral, portanto, pode ser usada para tratar doen\u00e7as como o glaucoma. Rogerio et al. estudaram os efeitos anti-inflamat\u00f3rios da quercetina e da isoquercitrina em modelos de asma em camundongos; os resultados mostraram que esses dois flavonoides s\u00e3o inibidores eficazes da inflama\u00e7\u00e3o eosinof\u00edlica e t\u00eam certo potencial para o tratamento de doen\u00e7as al\u00e9rgicas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nHuang et al. estudaram o mecanismo do efeito da isoquercitrina no c\u00e2ncer de f\u00edgado. Em experimentos in vitro, verificou-se que a isoquercitrina pode inibir a prolifera\u00e7\u00e3o de c\u00e9lulas cancer\u00edgenas e promover sua apoptose e, ao mesmo tempo, reduzir o n\u00edvel de express\u00e3o de PKC em c\u00e9lulas de c\u00e2ncer de f\u00edgado humano; em experimentos in vivo, a isoquercitrina tamb\u00e9m pode causar tumores transplantados em camundongos nus. A taxa de crescimento das c\u00e9lulas \u00e9 significativamente reduzida. Confirma-se que a isoquercitrina pode inibir significativamente a ocorr\u00eancia e o desenvolvimento do c\u00e2ncer de f\u00edgado, e seu mecanismo molecular pode estar relacionado \u00e0s vias de sinaliza\u00e7\u00e3o da PKC e da MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nJi Lili comparou a atividade hipoglic\u00eamica in vitro da isoquercitrina e dos flavonoides totais das folhas de Moringa oleifera. Os resultados mostraram que ambos podem aumentar significativamente o consumo de glicose pelas c\u00e9lulas HepG2, e o efeito hipoglic\u00eamico da isoquercitrina \u00e9 significativamente mais forte do que o dos flavonoides totais; estudos posteriores descobriram que seu mecanismo hipoglic\u00eamico \u00e9 aumentado principalmente pela inibi\u00e7\u00e3o da atividade da DPP-4 e a secre\u00e7\u00e3o de insulina tamb\u00e9m regula positivamente a express\u00e3o de InsR, PKA e PKC\u03b1, aumentando assim o efeito da insulina e promovendo a prolifera\u00e7\u00e3o das c\u00e9lulas do f\u00edgado e das ilhotas pancre\u00e1ticas.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nYun et al. discutiram a atividade antif\u00fangica da isoquercitrina e seu mecanismo de a\u00e7\u00e3o; os resultados mostraram que a isoquercitrina tem um forte efeito no teste de suscetibilidade de fungos patog\u00eanicos, e nenhuma hem\u00f3lise foi encontrada. Al\u00e9m disso, a candida albicans tamb\u00e9m foi testada quanto \u00e0 libera\u00e7\u00e3o de malonil iodeto e pot\u00e1ssio, confirmando que a isoquercitrina pode interferir na membrana celular e aumentar sua permeabilidade para promover danos \u00e0 membrana, exercendo assim atividade antibacteriana. Kim et al. descobriram que a isoquercitrina pode inibir a replica\u00e7\u00e3o dos v\u00edrus influenza A e B e, quando usada em conjunto com a amantadina e o oseltamivir, pode inibir efetivamente o surgimento de v\u00edrus resistentes, indicando que a isoquercitrina pode inibir efetivamente o surgimento de v\u00edrus resistentes. Ela tem um certo potencial de aplica\u00e7\u00e3o para o tratamento da gripe viral.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\nSe precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nComposto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCelulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUrease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nMalato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nColesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/pt\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"pt-BR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nAl\u00e9m dos efeitos acima, a isoquercitrina tamb\u00e9m tem atividades fisiol\u00f3gicas, como antiosteoporose, redu\u00e7\u00e3o da press\u00e3o arterial, lip\u00eddios sangu\u00edneos, neuroprote\u00e7\u00e3o e antidepress\u00e3o. A aplica\u00e7\u00e3o da \u03b1-L-rhamnosidase na biotransforma\u00e7\u00e3o da rutina ser\u00e1 apresentada mais adiante.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
- \n
- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n
- \n
- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nEntre em contato conosco agora!<\/b><\/strong><\/h2>\r\n
Se precisar do Price, preencha suas informa\u00e7\u00f5es de contato no formul\u00e1rio abaixo. Normalmente, entraremos em contato dentro de 24 horas. Voc\u00ea tamb\u00e9m pode me enviar um e-mail\u00a0info@longchangchemical.com<\/a><\/span>\u00a0durante o hor\u00e1rio comercial (das 8h30 \u00e0s 18h UTC+8 de segunda a s\u00e1bado) ou use o bate-papo ao vivo do site para obter uma resposta imediata.<\/b><\/strong><\/h4>\r\n
\r\n\r\n
\r\n Composto Glucoamilase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\n Pullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\n Xilanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\n Celulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\n Naringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n \u03b2-Amilase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\n Glucose oxidase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\n alfa-Amilase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\n Pectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\n Peroxidase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\n Lipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\n Catalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\n TANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\n Elastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\n Urease<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\n DEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\n L-L\u00e1ctico desidrogenase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\n Malato desidrogenase<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\n Colesterol oxidase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":" 1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n