July 9, 2024 Longchang Chemical

Tetraethylammonium Chloride CAS 56-34-8

Molecular Formula: C8H20ClN

Molecular Weight:165.7

Appearance: White crystal powder

Tetraethylammonium Chloride

Meltingpoint 39 °C
density 1.08 g/mL
Boiling point 273.32°C (rough estimate)
Color white
Refractive index 1.5480 (estimate)
solubility Soluble in water, ethanol, chloroform, or acetone

Tetraethylammonium Chloride Usage

1. Facilitating organic synthesis

As an important bio-based platform chemical, the production of 5-hydroxymethylfurfural (HMF) from the abundant substrate cellulose has attracted much attention. However, cumbersome reaction steps are unavoidable due to the complex tandem transformations of solubilization, hydrolysis and dehydration. In addition, the degradation of HMF is exacerbated by the harsh reaction conditions due to the extremely low solubility of cellulose.

Qinrui Du et al. investigated the structural changes of microcrystalline cellulose (MCC) after dissolution and regeneration in different dimethylsulfoxide (DMSO)/deep eutectic solvents (DESs) to elucidate the mechanism of dissolution [1]. The results showed that highly crystalline cellulose I in MCC was converted to amorphous cellulose II by DMSO/tetraethylammonium chloride (TEAC) treatment, leading to complete dissolution of MCC. Therefore, a dissolution-catalytic coupled reaction strategy was proposed to convert MCC to HMF by a one-pot method in DMSO/tetraethylammonium chloride, while reducing the number of steps required for the reaction and obtaining mild reaction conditions. Furthermore, the one-pot reaction pathway was clarified by analyzing the intermediate yields.The combination of AlCl3 as catalyst with DMSO/tetraethylammonium chloride resulted in 93.3 wt% MCC conversion and 53.1% HMF yield. Thus, the proposed reaction strategy makes possible the efficient production of HMF from cellulose.

2. Promotion of electrochemical reactions

Electrosolvency-coupled synthesis of hafnium alkyd [Hf(OR)4, R is alkyl] – ehs is a promising pathway for the green and efficient electrosynthesis of Hf(OR)4 alternative to the conventional thermal synthesis method.The EHS process uses ethanol and metallic Hf as feedstock, and performs simultaneous non-homogeneous phase reactions of Hf solvation and dehydrogenation from ethanol as well as a spontaneous solution-binding reaction of the Hf4+ cation and the alkoxylate anion.

To elucidate the mechanism and kinetics of anodic Hf dissolution and cathodic ethanol dehydrogenation, Shuai Li et al [2] explored the mechanism of the effect of the loading electrolyte and determined that tetraethylammonium chloride (Et4NCl) was more suitable with anhydrous ethanol. The tetraethylammonium chloride EHS process exhibited a strong pitting mechanism, i.e., breakdown of the passivation film to dissolve Hf and a two-stage dehydrogenation mechanism. Three metrics related to passivation rate, susceptibility of passivation film to breakdown and pitting rate were extracted to quantify the kinetics of passivation breakdown and Hf corrosion. Numerical models were developed to quantify the dehydrogenation kinetics. A microkinetic model was developed to evaluate the tetraethylammonium chloride EHS process and experimentally validated. The electrochemical results provide theoretical guidance for the efficient operation of the EHS process.

3. Reduction of neurotoxicity of isoflurane

Isoflurane, or isoflurane, is a commonly used general anesthetic to induce or maintain anesthesia. Due to its neurotoxicity, side effects include including depressing the respiratory center, lowering blood pressure and causing cardiac arrhythmias. More serious side effects include malignant hyperthermia and hyperkalemia.

Tetraethylammonium Chloride Packaging and Shipping

Packing: 25kg/bag

Tetraethylammonium Chloride Storage

Stored in a cool dry ventilated warehouse away from fire, heat and direct sunlight

Other Name:



N,N,N-Triethyl-ethanaminium chloride;

Tetraethyl ammonium chloride;

Tetraethylammonium chloride hydrate;


TEA chloride;


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