Phenolphthalein Application scenarios
1. Acid-Base Indicator (Most important and classic application)
• Principle: Colorless in acidic or neutral solutions, turns purplish-red in alkaline solutions.
• Specific Applications
• Chemical Experiment Teaching and Analysis: Used in acid-base titration experiments to visually indicate the reaction endpoint (commonly used color change range: pH 8.2-10.0).
• Chemical Production Process Control: For rapid detection of the acidity or alkalinity of liquid products.
• Daily Science Education and Testing: Used to make “invisible ink” or test the acidity or alkalinity of substances (e.g., soil, household liquids, etc.).
2. Pharmaceutical Field (Historically widely used, now strictly prohibited)
• Past Use: Formerly used as a main ingredient in stimulant laxatives to treat constipation.
• Current Status: Due to serious side effects such as potential carcinogenicity, electrolyte imbalance, and intestinal dysfunction from long-term use, many countries including China, the United States, and the European Union have completely banned its use as a pharmaceutical raw material.
3. Industrial and Special Uses
• Cement Accelerating Admixture Component: Used as a component in some cement additives, utilizing its chemical properties.
• Fluorescent Dye Precursor: Its molecular structure can be used to synthesize certain fluorescent dyes.
• Research Reagent: Used as a synthetic intermediate or as a subject of characteristic research in chemical research.
Description
Phenolphthalein CAS 77-09-8
| Item |
Specifications |
| Characteristics |
A white or almost white powder, practically insoluble in water, soluble in alcohol. |
| Melting Point |
It melts at about 260℃ |
| Identification |
A：Positive B：Positive |
| Appearance of solution |
The solution is clear and not more intensely coloured than reference solution Y7 |
| Related substances |
Less than 0.5% |
| Heavy metals |
Not more than0.001% |
| Acidity or alkalinity |
Complies |
| Chlorides |
Not more than 0.01% |
| Sulphates |
Not more than 0.02% |
| Loss on drying |
Not more than 0.5% |
| Sulphated ash |
Not more than 0.1% |
| Assay |
98.0%-101.0%(C2OHi4O4) |
| Microorganism |
TPC<1000cfu/g |
| Y and M <100cfu/g |
| E-coli – absent |
| Staphylococcus Aureus-Absent |
| Pseudomonas Aeruginosa-Absent |
| Albicans Saccharomyces-Absent |
Phenolphthalein Usage
1. Phenolphthalein is a weak organic acid. It is white or slightly yellowish fine crystals at room temperature. It is odorless and tasteless. It is hardly soluble in water but easily soluble in alcohol (ethanol) and ether. Dissolved in alcohol solution to make acid-base indicator, it is colorless in acid solution, red in lye or alkali metal carbonate solution, but if it is in concentrated alkali solution, it will generate colorless trimetal The salt, the red faded. In view of this characteristic, it is often used as an indicator of acid-base titration in laboratories. The color range of PH value is 8.2～10.0, from colorless to red. When the phenolphthalein reagent is dripped into water or a neutral, acidic aqueous solution, white turbidity will appear. This is because alcohol is easily soluble in water and the phenolphthalein, which is hardly soluble in water, precipitates out in the reagent.
2. Pharmaceutical Ingredients: Phenolphthalein is used as a pharmaceutical light laxative for habitual and persistent constipation. It is available in tablets, suppositories and other dosage forms, mainly in the colon, through the decomposition of the body to form soluble sodium salts, stimulate the nerve plexus in the intestinal wall, so that peristalsis increases and promote defecation.
3. Organic synthesis: Phenolphthalein is also used in the synthesis of plastics, especially the synthesis of diazanaphthone polyarylether ketone polyarylether ketone polymers. These polymers have good heat resistance, water resistance, chemical resistance, heat aging resistance and processing and shaping, made of fibres, coatings and composites are widely used in electrical and electronic appliances, machinery and equipment, transportation, aerospace, atomic energy engineering and military and other fields.
4. Chemical analysis: Phenolphthalein can be used as an endocrinator for the colocal determination of key acidity and detection of magnesium ions. Phenolphthalein as an endocrinator can indicate the concentration of Chinese acid. In the detection of magnesium ions, phenolphthalein can indicate the presence and concentration of magnesium ions.
5. Biochemical trails: Phenolphthalein may be used as an identifier for some biochemical tests to detect the presence or absence of traits, e.g. detection of the presence of enzyme reactions and metabolic activity.
6. Pharmaceuticals and pigments: Phenolphthalein can be prepared as a synthetic compound for some organopharmaceuticals and pigments. It can be used as a preparation to give different colours to rolls and other materials.
PhenolphthaleinPackaging and Shipping
Fiber Drum,25kg
Phenolphthalein Storage
Store in a cool, dry place.
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