{"id":4427,"date":"2021-03-03T02:52:18","date_gmt":"2021-03-03T02:52:18","guid":{"rendered":"https:\/\/longchangchemical.com\/?p=4427"},"modified":"2025-02-19T03:33:48","modified_gmt":"2025-02-19T03:33:48","slug":"overview-of-glycoside-hydrolase","status":"publish","type":"post","link":"https:\/\/longchangchemical.com\/nl\/overview-of-glycoside-hydrolase\/","title":{"rendered":"Overzicht van glycoside hydrolase"},"content":{"rendered":"

Overzicht van glycoside hydrolase<\/h1>\r\n

Mijn naam is Harold en ik herinner me nog de schok die ik voelde toen ik voor het eerst de kristallisatie van de glycoside in ginkgobladextract onder de microscoop zag - die kleine zeshoekige kristallen bevatten het potentieel om de ziekte van Alzheimer te bestrijden. Als chemicus die al 15 jaar onderzoek doet naar natuurlijke producten, zal ik je meenemen in dit moleculaire koninkrijk dat is geweven van suiker en leven, en onthullen hoe glycosiden zijn ge\u00ebvolueerd van een verdedigingsmechanisme van planten tot een schatkamer van de moderne geneeskunde.<\/h3>\r\n

1. Glycosiden: het chemische codeboek van de natuur<\/h4>\r\n

De kunst van de suikerkettingtaal<\/strong><\/p>\r\n

Planten schrijven hun overlevingsepos in glycosiden: de suikergroep werkt als een \"moleculair schild\" om het actieve aglucon te beschermen. Deze ingenieuze binaire structuur is de inspiratiebron voor 70% moderne medicijnen. Tijdens mijn onderzoek in het regenwoud van de Amazone ontdekte ik dat lokale stammen de afscheidingen van cardiotone pijlgifkikkers als wapens gebruiken en moderne farmaceutische bedrijven gebruiken hetzelfde principe om medicijnen voor het hart te ontwikkelen.<\/p>\r\n

Structuur bepaalt het lot<\/strong><\/p>\r\n

- Oxiden (bijv. digitalisglycosiden) - de hoeksteen van cardiovasculaire geneesmiddelen<\/p>\r\n

- Carbonylverbindingen (bijv. baicale\u00efne) - donkere paarden in het antivirale veld<\/p>\r\n

- Stikstofhoudende verbindingen (bijv. purine nucleosiden) - het arsenaal van geneesmiddelen tegen kanker<\/p>\r\n

Uit het onderzoek van ons team in 2021 bleek dat het veranderen van de configuratie van de hydroxylgroep op de C-2 positie van glucose in notoginsenoside de antistollingsactiviteit met 3,7 keer kan verhogen.<\/p>\r\n

2. Het evolutionaire pad van suikerketens ontsluiten<\/h4>\r\n

De inspiratie van academicus Zhang Shuzheng<\/strong><\/p>\r\n

Het vergeelde experimentele document uit 1958 beschrijft het beginpunt van glycosidenonderzoek in China. Ik had het geluk om het eerste-generatie papieren elektroforese-apparaat in het laboratorium van de academicus te zien - een eenvoudig apparaat gebouwd met filterpapier en een glazen plaat, maar het screende de rhizobiumstam die de enzymbereidingsindustrie veranderde. Deze geest van wetenschappelijk onderzoek inspireert ons: belangrijke doorbraken beginnen vaak met innovaties in basisinstrumenten.<\/p>\r\n

De drie belangrijkste wapens van moderne enzymtechnologie<\/strong><\/p>\r\n

    \r\n
  1. Gerichte evolutie: net als bij moleculaire alchemie hebben we Bacillus subtilis in staat gesteld de effici\u00ebntie van zijn enzymproductie 40 keer te verhogen.<\/li>\r\n
  2. Structurele biologie: cryo-elektronenmicroscopie onthult het werkingsmechanisme van de \"moleculaire schaar\" van het glycosidase<\/li>\r\n
  3. Synthetische biologie: de gistcelfabriek reconstrueren om zeldzame ginsenosiden te produceren<\/li>\r\n<\/ol>\r\n

    Doorbraken van pijnpunten in de industrie<\/strong><\/p>\r\n

    Een farmaceutisch bedrijf stond op het punt om de productie op te schorten omdat de extractiesnelheid van baicaline lager was dan 12%. Na de introductie van het thermofiele bacteri\u00eble glycosidase,<\/p>\r\n

    \u2192 het extractiepercentage steeg tot 89<\/p>\r\n

    \u2192 de hoeveelheid gebruikt organisch oplosmiddel werd verminderd met 75<\/p>\r\n

    \u2192 en 30.000 ton afvalwater per jaar gereduceerd<\/p>\r\n

    3. De toekomst van glycosidetechnologie<\/h4>\r\n

    De hypothese die mijn laboratorium verifieert<\/strong><\/p>\r\n

    Kunnen we \"slimme glycosiden\" ontwikkelen? We hebben geprobeerd om pH-responsieve glycaanketens te combineren met antikanker aglyconen om de automatische afgifte van geneesmiddelen in de tumormicro-omgeving (pH 5,5-6,5) mogelijk te maken. Muisproeven hebben een 60% toename in doelgerichtheid aangetoond, wat het paradigma van de toediening van chemotherapiemedicijnen kan herschrijven.<\/p>\r\n

    Routekaart voor industri\u00eble transformatie<\/strong><\/p>\r\n

      \r\n
    1. V\u00f3\u00f3r 2025: een glycoside fingerprint database opzetten voor belangrijke medicinale planten<\/li>\r\n
    2. Doel voor 2030: 80% van de glycosideproductie zal worden gekatalyseerd door enzymen.<\/li>\r\n
    3. Ultieme visie: kunstmatig ontworpen \"superglycosiden\" die de natuur overtreffen<\/li>\r\n<\/ol>\r\n

      Visuele suggesties<\/h3>\r\n
        \r\n
      1. Interactief glycosidestructuurmodel<\/b> (alternatieve tekst: vergelijking van de driedimensionale moleculaire structuren van oxiden\/carbonyls\/nitriles)<\/li>\r\n
      2. Enzymatische hydrolyse dynamisch diagram<\/b> (alternatieve tekst: animatie van het moleculaire mechanisme van glycosidase splitsing van de suikerketen)<\/li>\r\n
      3. Historisch technologisch vergelijkingstabel<\/b> (papieren elektroforese in 1958 vs moderne HPLC-MS-systemen)<\/li>\r\n<\/ol>\r\n

        Speciaal advies voor collega-onderzoekers<\/h3>\r\n

        De volgende keer dat je te maken hebt met slecht oplosbare glycosiden, probeer dan onze \"vuur en ijs\" methode:<\/p>\r\n

        \u2460 Snel invriezen met vloeibare stikstof om de celwanden van de plant te breken<\/p>\r\n

        \u2461 Elueer de doelcomponenten met een gradi\u00ebntenzym van 45 \u00b0C<\/p>\r\n

        Deze methode heeft de extractietijd van polydatine verkort van 12 uur tot 90 minuten en het desbetreffende artikel wordt momenteel door vakgenoten beoordeeld.<\/p>\r\n

        In een tijdperk waarin elke gram glycosiden miljoenen therapeutische mogelijkheden kan bevatten, zijn we niet alleen samengestelde tolken, maar ook vertalers van de code van het leven. Wanneer je een plantenextract in je handen houdt, bedenk dan dat de sleutel tot het genezen van ziekten van de volgende eeuw misschien wel in die stille suikerketens zit.<\/p>\r\n

        Neem nu contact met ons op!<\/b><\/strong><\/h2>\r\n

        Als je Price nodig hebt, vul dan je contactgegevens in op het formulier hieronder. We nemen dan meestal binnen 24 uur contact met je op. Je kunt me ook een e-mail sturen\u00a0info@longchangchemical.com<\/a><\/span>\u00a0tijdens kantooruren (8:30 tot 18:00 UTC+8 ma. ~ za.) of gebruik de live chat op de website voor een snel antwoord.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n
        Samenstelling Glucoamylase<\/span><\/a><\/td>\r\n9032-08-0<\/td>\r\n<\/tr>\r\n
        Pullulanase<\/span><\/a><\/td>\r\n9075-68-7<\/td>\r\n<\/tr>\r\n
        Xylanase<\/span><\/a><\/td>\r\n37278-89-0<\/td>\r\n<\/tr>\r\n
        Cellulase<\/span><\/a><\/td>\r\n9012-54-8<\/td>\r\n<\/tr>\r\n
        Naringinase<\/span><\/a><\/td>\r\n9068-31-9<\/td>\r\n<\/tr>\r\n
        \u03b2-amylase<\/span><\/a><\/td>\r\n9000-91-3<\/td>\r\n<\/tr>\r\n
        Glucose-oxidase<\/span><\/a><\/td>\r\n9001-37-0<\/td>\r\n<\/tr>\r\n
        alfa-amylase<\/td>\r\n9000-90-2<\/td>\r\n<\/tr>\r\n
        Pectinase<\/span><\/a><\/td>\r\n9032-75-1<\/td>\r\n<\/tr>\r\n
        Peroxidase<\/td>\r\n9003-99-0<\/td>\r\n<\/tr>\r\n
        Lipase<\/span><\/a><\/td>\r\n9001-62-1<\/td>\r\n<\/tr>\r\n
        Katalase<\/span><\/a><\/td>\r\n9001-05-2<\/td>\r\n<\/tr>\r\n
        TANNASE<\/span><\/a><\/td>\r\n9025-71-2<\/td>\r\n<\/tr>\r\n
        Elastase<\/span><\/a><\/td>\r\n39445-21-1<\/td>\r\n<\/tr>\r\n
        Urease<\/span><\/a><\/td>\r\n9002-13-5<\/td>\r\n<\/tr>\r\n
        DEXTRANASE<\/span><\/a><\/td>\r\n9025-70-1<\/td>\r\n<\/tr>\r\n
        L-Lactische dehydrogenase<\/span><\/a><\/td>\r\n9001-60-9<\/td>\r\n<\/tr>\r\n
        Dehydrogenase malaat<\/span><\/a><\/td>\r\n9001-64-3<\/td>\r\n<\/tr>\r\n
        Cholesteroloxidase<\/span><\/a><\/td>\r\n9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"

        Overview of glycoside hydrolase My name is Harold, and I still remember the shock I felt when I first observed the crystallization of the glycoside in ginkgo leaf extract under the microscope \u2013 those tiny hexagonal crystals contained the potential to combat Alzheimer’s disease. As a chemist who has been researching natural products for 15 […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4427","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\nOverview of glycoside hydrolase - Longchang chemical Co., Ltd.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/nl\/overview-of-glycoside-hydrolase\/\" \/>\n<meta property=\"og:locale\" content=\"nl_NL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Overview of glycoside hydrolase - Longchang chemical Co., Ltd.\" \/>\n<meta property=\"og:description\" content=\"Overview of glycoside hydrolase My name is Harold, and I still remember the shock I felt when I first observed the crystallization of the glycoside in ginkgo leaf extract under the microscope \u2013 those tiny hexagonal crystals contained the potential to combat Alzheimer’s disease. As a chemist who has been researching natural products for 15 […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/nl\/overview-of-glycoside-hydrolase\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-03T02:52:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-19T03:33:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Overview of glycoside hydrolase\",\"datePublished\":\"2021-03-03T02:52:18+00:00\",\"dateModified\":\"2025-02-19T03:33:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/\"},\"wordCount\":789,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"nl-NL\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/\",\"url\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/\",\"name\":\"Overview of glycoside hydrolase - Longchang chemical Co., Ltd.\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"datePublished\":\"2021-03-03T02:52:18+00:00\",\"dateModified\":\"2025-02-19T03:33:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#breadcrumb\"},\"inLanguage\":\"nl-NL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Overview of glycoside hydrolase\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"nl-NL\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"nl-NL\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/nl\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Overzicht van glycoside hydrolase - Longchang chemical Co, Ltd.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/nl\/overview-of-glycoside-hydrolase\/","og_locale":"nl_NL","og_type":"article","og_title":"Overview of glycoside hydrolase - Longchang chemical Co., Ltd.","og_description":"Overview of glycoside hydrolase My name is Harold, and I still remember the shock I felt when I first observed the crystallization of the glycoside in ginkgo leaf extract under the microscope \u2013 those tiny hexagonal crystals contained the potential to combat Alzheimer’s disease. As a chemist who has been researching natural products for 15 […]","og_url":"https:\/\/longchangchemical.com\/nl\/overview-of-glycoside-hydrolase\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-03T02:52:18+00:00","article_modified_time":"2025-02-19T03:33:48+00:00","og_image":[{"width":1000,"height":1000,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg","type":"image\/jpeg"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Overview of glycoside hydrolase","datePublished":"2021-03-03T02:52:18+00:00","dateModified":"2025-02-19T03:33:48+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/"},"wordCount":789,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"articleSection":["Enzyme News"],"inLanguage":"nl-NL","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/","url":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/","name":"Overzicht van glycoside hydrolase - Longchang chemical Co, Ltd.","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"datePublished":"2021-03-03T02:52:18+00:00","dateModified":"2025-02-19T03:33:48+00:00","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#breadcrumb"},"inLanguage":"nl-NL","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/overview-of-glycoside-hydrolase\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"Overview of glycoside hydrolase"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"Chemisch bedrijf Longchang","description":"China chemische fabrikant \uff06 leverancier","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"nl-NL"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"Chemisch bedrijf Longchang","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"nl-NL","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"Chemisch bedrijf Longchang","image":{"@type":"ImageObject","inLanguage":"nl-NL","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/nl\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/posts\/4427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/comments?post=4427"}],"version-history":[{"count":5,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/posts\/4427\/revisions"}],"predecessor-version":[{"id":7905,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/posts\/4427\/revisions\/7905"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/media?parent=4427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/categories?post=4427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/nl\/wp-json\/wp\/v2\/tags?post=4427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}