{"id":7255,"date":"2024-08-20T11:36:15","date_gmt":"2024-08-20T11:36:15","guid":{"rendered":"https:\/\/longchangchemical.com\/?p=7255"},"modified":"2026-04-28T10:42:33","modified_gmt":"2026-04-28T10:42:33","slug":"chemistry-approach-in-industrial-enzyme-research","status":"publish","type":"post","link":"https:\/\/longchangchemical.com\/ko\/chemistry-approach-in-industrial-enzyme-research\/","title":{"rendered":"\uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0\uc11c\uc758 \uacc4\uc0b0 \ud654\ud559 \uc811\uadfc \ubc29\uc2dd\uc740 \ubb34\uc5c7\uc778\uac00\uc694?"},"content":{"rendered":"<h1>\uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0\uc11c\uc758 \uacc4\uc0b0 \ud654\ud559 \uc811\uadfc \ubc29\uc2dd\uc740 \ubb34\uc5c7\uc778\uac00\uc694?<\/h1>\n<p><!-- lc-qa-start --><\/p>\n<p><strong>\ube60\ub978 \ub2f5\ubcc0:<\/strong> \uc2e4\uc6a9\uc801\uc778 \ud6a8\uc18c \ub610\ub294 \uc2dd\ud488 \uc131\ubd84 \uacb0\uc815\uc740 \uacf5\uc815 \ubaa9\ud45c\ub85c \uc2dc\uc791\ud558\uc5ec, \ud65c\uc131, \uc801\uc6a9 \ubc94\uc704, \uac10\uac01 \uc601\ud5a5, \uadf8\ub9ac\uace0 \ubc30\uce58 \uac04 \uc77c\uad00\uc131\uc744 \ud655\uc778\ud55c \ud6c4 \uc2a4\ucf00\uc77c\uc5c5\uc744 \uc9c4\ud589\ud569\ub2c8\ub2e4.<\/p>\n<p><!-- lc-qa-end --><\/p>\n<p>\uc774 \ub17c\ubb38\uc740 \ubd84\uc790 \uc5ed\ud559 \ud798\uc7a5 \ubc0f \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158, \uc591\uc790\uc5ed\ud559 \ubc0f \uc591\uc790\uc5ed\ud559\/\ubd84\uc790 \uc5ed\ud559 \uacb0\ud569 \ubaa8\ub378\ub9c1, \uc5f0\uc18d\uccb4 \uc815\uc804\uae30 \ubaa8\ub378\ub9c1 \ubc0f \ubd84\uc790 \ub3c4\ud0b9\uc744 \ud3ec\ud568\ud558\uc5ec \uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c, \ud2b9\ud788 \ud6a8\uc18c \uacf5\ud559 \uc548\ub0b4\ub97c \uc704\ud574 \uc0ac\uc6a9\ub418\ub294 \uc8fc\uc694 \uacc4\uc0b0 \ud654\ud559 \ubc29\ubc95\uc744 \uc18c\uac1c\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubc29\ubc95\ub4e4\uc740 \uac01\uac01 \ub450 \uac00\uc9c0 \uad00\uc810\uc5d0\uc11c \uc694\uc57d\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4: \uccab\uc9f8, \ubc29\ubc95 \uc790\uccb4\uc758 \uae30\ubcf8 \uac1c\ub150, \uc6d0\ub798 \uacc4\uc0b0\uc758 \uacb0\uacfc, \uc801\uc6a9 \uac00\ub2a5 \uc870\uac74 \ubc0f \uc7a5\ub2e8\uc810, \ub458\uc9f8, \uacc4\uc0b0\uc5d0\uc11c \uc5bb\uc740 \uc720\uc6a9\ud55c \uc815\ubcf4\ub97c \ud1b5\ud574 \ub3cc\uc5f0\ubcc0\uc774 \ubc0f \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc758 \uc124\uacc4\ub97c \uc548\ub0b4\ud569\ub2c8\ub2e4.<\/p>\n<p>\ud6a8\uc18c\uc758 \uc0b0\uc5c5\uc801 \uc751\uc6a9\uc740 100\ub144\uc758 \uc5ed\uc0ac\ub97c \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \ud6a8\uc18c \ucd09\ub9e4\ub294 \uace0\ud6a8\uc728, \ub192\uc740 \ud2b9\uc774\uc131 \ubc0f \uc120\ud0dd\uc131, \ud658\uacbd \uce5c\ud654\uc131\uc73c\ub85c \uc778\ud574 \uc2dd\ud488, \ub18d\uc5c5, \uc758\ud559 \ubc0f \ud654\ud559 \uc0b0\uc5c5\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \uc0b0\uc5c5\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. <sup>[1-2].<\/sup> \uc0b0\uc5c5 \uc751\uc6a9 \ud658\uacbd\uc740 \ud6a8\uc18c\uac00 \uc790\uc5f0\uc5d0\uc11c \uc0b4\uc544\uac00\ub294 \ud658\uacbd\uacfc \ud06c\uac8c \ub2e4\ub974\uae30 \ub54c\ubb38\uc5d0 \ucc9c\uc5f0 \ud6a8\uc18c\uc758 \ud2b9\uc131\uacfc \ucd09\ub9e4 \uae30\ub2a5 \ubc0f \uc751\uc6a9 \ud658\uacbd\uc774 \uc77c\ubc18\uc801\uc73c\ub85c \uc77c\uce58\ud558\uc9c0 \uc54a\uac70\ub098 \ucd5c\uc801\uc774 \uc544\ub2d9\ub2c8\ub2e4. \uc774 \uacbd\uc6b0 \ud6a8\uc18c\uc758 \uc131\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uae30 \uc704\ud574 \ud6a8\uc18c \uacf5\ud559\uc758 \ub3c4\uc6c0\uc73c\ub85c \ud6a8\uc18c\uc758 \ucc9c\uc5f0 \uc544\ubbf8\ub178\uc0b0 \uc11c\uc5f4\uc744 \uc218\uc815\ud560 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. <sup>[3].<\/sup> \uac00\uc7a5 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ud6a8\uc18c \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1 \uc804\ub7b5\uc740 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \uc704\ud55c \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac \uad6c\ucd95, \uc989 \uc2e4\ud5d8\uc2e4 \uc8fc\ub3c4 \uc9c4\ud654\uc785\ub2c8\ub2e4. <sup>[4].<\/sup> \ud6a8\uacfc\uc801\uc778 \uc9c1\uc811 \uc9c4\ud654\ub97c \uc704\ud55c \ud544\uc218 \uc804\uc81c \uc870\uac74 \uc911 \ud558\ub098\ub294 \uc2a4\ud06c\ub9ac\ub2dd \uc911\uc778 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc758 \ub77c\uc774\ube0c\ub7ec\ub9ac \uc6a9\ub7c9(\uc989, \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0 \ud3ec\ud568\ub41c \ub3cc\uc5f0\ubcc0\uc774\uc758 \uc218)\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac \ub0b4 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc720\uc775\ud55c \ub3cc\uc5f0\ubcc0\uc774\uc758 \ube44\uc728\uc5d0 \ube44\ud574 \ucda9\ubd84\ud788 \ud06c\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc758 \ud06c\uae30\ub294 \uc2a4\ud06c\ub9ac\ub2dd \ubc29\ubc95, \uc0ac\uc6a9 \uac00\ub2a5\ud55c \ub9ac\uc18c\uc2a4 \ubc0f \uae30\ud0c0 \uac1d\uad00\uc801\uc778 \uc870\uac74\uc5d0 \uc758\ud574 \uc81c\ud55c\ub418\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \ud575\uc2ec \ubb38\uc81c\ub294 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0\uc11c \ud6a8\uacfc\uc801\uc778 \ub3cc\uc5f0\ubcc0\uc774\uc758 \ube44\uc728\uc744 \ub192\uc774\ub294 \ubc29\ubc95\uc785\ub2c8\ub2e4. \ud6a8\uc18c \uc11c\uc5f4, \uad6c\uc870 \ubc0f \uc911\uc694\ud55c \ud2b9\uc131 \uac04\uc758 \uad00\uacc4\ub97c \uc2ec\uce35\uc801\uc73c\ub85c \uc774\ud574\ud558\uba74 \ub3cc\uc5f0\ubcc0\uc774 \ud56b\uc2a4\ud31f\uc744 \uc2dd\ubcc4\ud558\uace0 \ub3cc\uc5f0\ubcc0\uc774 \ubc94\uc704\ub97c \uc81c\ud55c\ud558\uba70 \uc591\uc9c8\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac \uc124\uacc4\ub97c \uc2e4\ud604\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc804\uc0b0 \ud654\ud559 \ubc29\ubc95\uc740 \uc774\ub7ec\ud55c \uc774\ud574\ub97c \uc5bb\ub294 \uc911\uc694\ud55c \uc218\ub2e8\uc785\ub2c8\ub2e4. \uacc4\uc0b0 \uc124\uacc4\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \uacc4\uc0b0 \uc124\uacc4 \ub2e8\ubc31\uc9c8 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub294 \ubb34\uc791\uc704 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc5d0 \ube44\ud574 \ud6a8\uacfc\uc801\uc778 \ub3cc\uc5f0\ubcc0\uc774\uc758 \ube44\uc728\uc744 \uba87 \ubc30\ub098 \ub192\uc77c \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. <sup>[5].<\/sup> \uc77c\ubd80 \uc5b4\ub824\uc6b4 \ud6a8\uc18c \uacf5\ud559\uc774\ub098 \ub2e8\ubc31\uc9c8 \uacf5\ud559\uc758 \uacbd\uc6b0, \uacc4\uc0b0\uc774 \uac00\uc838\uc62c \uc218 \uc788\ub294 \uc0c1\ub2f9\ud55c \uac1c\uc120\uc740 \ub354 \uc774\uc0c1 \ud6a8\uc728\uc131 \ud5a5\uc0c1\uc5d0 \uad6d\ud55c\ub418\uc9c0 \uc54a\uace0 \uad81\uadf9\uc801\uc778 \uc131\ud328\ub97c \uacb0\uc815\ud560 \uc218 \uc788\uc744 \ub9cc\ud07c \ucda9\ubd84\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\uc81c\ub85c \uacc4\uc0b0 \ud654\ud559\uacfc \uacc4\uc0b0 \uc0dd\ubb3c\ud559 \ubc29\ubc95\uc740 \uc790\uc5f0 \ud6a8\uc18c\uac00 \uac16\uc9c0 \ubabb\ud55c \ucd09\ub9e4 \uae30\ub2a5\uc744 \uac00\uc9c4 \uc778\uacf5 \ud6a8\uc18c\ub97c \ucc98\uc74c\ubd80\ud130 \uc124\uacc4\ud558\ub294 \ub370 \uc131\uacf5\ud588\uc2b5\ub2c8\ub2e4. \ub2e4\ub978 \ub9ac\ubdf0\uc5d0\uc11c\ub294 \uc544\ubbf8\ub178\uc0b0 \uc11c\uc5f4\uc758 \ucd5c\uc801 \uc124\uacc4\ub97c \uc790\ub3d9\ud654\ud558\ub294 \ubc29\ubc95\uc5d0 \ub300\ud574 \ub2e4\ub8e8\uc5c8\uc73c\ubbc0\ub85c \uc774 \ub17c\ubb38\uc5d0\uc11c\ub294 \uc8fc\uc5b4\uc9c4 \uc544\ubbf8\ub178\uc0b0 \uc11c\uc5f4\uc744 \uac00\uc9c4 \ud6a8\uc18c\ub97c \uc2dc\ubbac\ub808\uc774\uc158\ud558\uace0 \ubd84\uc11d\ud558\ub294 \uacc4\uc0b0 \ubc29\ubc95\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd9c \uac83\uc785\ub2c8\ub2e4. \ubb3c\ub860 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ub7ec\ud55c \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc57c\uc0dd\ud615\uacfc \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac1c\ubcc4\uc801\uc73c\ub85c \uc5f0\uad6c\ud55c \ub2e4\uc74c \uacb0\uacfc\ub97c \ube44\uad50\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ub2e8\ubc31\uc9c8, \ud2b9\ud788 \ud6a8\uc18c\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc624\ub7ab\ub3d9\uc548 \uacc4\uc0b0 \ud654\ud559 \uc5f0\uad6c\uc758 \uc911\uc694\ud55c \uc601\uc5ed\uc774\uc5c8\uc2b5\ub2c8\ub2e4. <sup>[6-8].<\/sup> \uc8fc\uc694 \ubc29\ubc95\uc73c\ub85c\ub294 \uace0\uc804 \ubd84\uc790 \uc5ed\ud559 \uc5ed\uc7a5 \uae30\ubc18\uc758 \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158(\uace0\uc804 MD)\uc774 \uc788\uc2b5\ub2c8\ub2e4. <sup>[9],<\/sup> \uc591\uc790 \uc5ed\ud559(QM) <sup>[10] \ubc0f<\/sup> \uc591\uc790 \uc5ed\ud559\/\ubd84\uc790 \uc5ed\ud559(QM\/MM) \uacb0\ud569 \ubc29\ubc95 <sup>[8,11-12],<\/sup> \ubd84\uc790 \uac04 \ubcf5\ud569\uccb4 \uc608\uce21, \uc989 \ubd84\uc790 \ub3c4\ud0b9(\ub3c4\ud0b9) <sup>[13], \uadf8\ub9ac\uace0<\/sup> \uc815\uc804\uae30 \ubc0f \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \uc815\ub7c9\ud654\ud558\uae30 \uc704\ud55c \ud3b8\uad11 \uc5f0\uc18d\uccb4 \ubaa8\ub378(PCM) [ <sup>14].<\/sup> \ud478\uc544\uc1a1-\ubcfc\uce20\ub9cc \ubaa8\ub378(PB)\uacfc \uac19\uc740) <sup>[14],<\/sup> \uadf8\ub9ac\uace0 \uae30\ud558\ud559\uc801 \uc18d\uc131\uc5d0 \uae30\ubc18\ud55c \uc77c\ubd80 \ubaa8\ub378\uc785\ub2c8\ub2e4. \uc774 \ubc31\uc11c\uc5d0\uc11c\ub294 \uccab\uc9f8, \uae30\ubcf8 \uc6d0\ub9ac, \ub3c5\ucc3d\uc801\uc778 \uacc4\uc0b0 \uacb0\uacfc, \uc801\uc6a9 \uac00\ub2a5\uc131 \uc870\uac74, (\uc7a0\uc7ac\uc801\uc778) \uc7a5\ub2e8\uc810 \ub4f1 \ubc29\ubc95 \uc790\uccb4\uc5d0 \ub300\ud55c \uac1c\uc694\ub97c \ub450 \uac00\uc9c0 \uad00\uc810\uc5d0\uc11c \uc0b4\ud3b4\ubcf4\uace0, \ub458\uc9f8, \uc774\ub7ec\ud55c \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \ucd09\ub9e4 \uad00\ub828 \uba54\ucee4\ub2c8\uc998\uc5d0 \ub300\ud55c \ub354 \uae4a\uc740 \uc774\ud574\uc640 \uc774\ub860\uc801 \uc608\uce21 \ub610\ub294 \uc124\uba85\uacfc \uac19\uc740 \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1 \uad00\ub828 \uc815\ubcf4\ub97c \uc5bb\ub294 \ubc29\ubc95\uc5d0 \ub300\ud574 \uc124\uba85\ud569\ub2c8\ub2e4.\ub458\uc9f8, \uc774\ub7ec\ud55c \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \ucd09\ub9e4 \uad00\ub828 \uba54\ucee4\ub2c8\uc998\uc5d0 \ub300\ud55c \ub354 \uae4a\uc740 \uc774\ud574, \uc57c\uc0dd\ud615\uc5d0 \ub300\ud55c \ub2e4\uc591\ud55c \ub3cc\uc5f0\ubcc0\uc774\uc758 \ud2b9\uc131 \ub610\ub294 \uae30\ub2a5 \ubcc0\ud654\uc5d0 \ub300\ud55c \uc774\ub860\uc801 \uc608\uce21 \ub610\ub294 \uc124\uba85\uacfc \uac19\uc740 \uacf5\ud559 \uad00\ub828 \uc815\ubcf4\ub97c \uc5bb\ub294 \ubc29\ubc95, \uc989 \uc720\ub3c4 \uc9c4\ud654\ub97c \uc704\ud55c \uace0\ud488\uc9c8 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac \uc124\uacc4 \ub610\ub294 \uace0\ud488\uc9c8 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac \uc124\uacc4 \ub610\ub294 \ub3cc\uc5f0\ubcc0\uc774 \uc740\ud589 \uc124\uacc4, \uc6d0\uc2dc \uacc4\uc0b0 \uacb0\uacfc \ubd84\uc11d\uc744 \uae30\ubc18\uc73c\ub85c \ud2b9\uc815 \ub3cc\uc5f0\ubcc0\uc774 \ubd80\uc704 \ubc0f \ub3cc\uc5f0\ubcc0\uc774 \uc720\ud615 \uc81c\uc548 \ub4f1\uc5d0 \ub300\ud574 \uc124\uba85\ud569\ub2c8\ub2e4.<\/p>\n<p>1<\/p>\n<p>\uace0\uc804 \ubd84\uc790 \uc5ed\ud559 \uc5ed\uc7a5(MM)\uc5d0 \uae30\ubc18\ud55c \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158(MD)<\/p>\n<p>1.1<\/p>\n<p>\ubc29\ubc95 \uc18c\uac1c<\/p>\n<p>\ub2f9\ubd84\uac04 \ud6a8\uc18c \ucd09\ub9e4\uc640 \uad00\ub828\ub41c \ud654\ud559\uc801 \ubcc0\ud654\ub294 \uace0\ub824\ud558\uc9c0 \uc54a\uace0 \ubd84\uc790 \uc5f4 \uc6b4\ub3d9\uc73c\ub85c \uc778\ud55c \ud6a8\uc18c\uc758 \ud615\ud0dc \ubcc0\ud654, \ud6a8\uc18c\uc640 \ubc18\uc751\ubb3c(\ub610\ub294 \uc0dd\uc131\ubb3c) \uc0ac\uc774\uc758 \ube44\uacf5\uc720 \ubcf5\ud569\uccb4 \ud615\uc131 \ubc0f \ud574\ub9ac \uacfc\uc815\ub9cc \uace0\ub824\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacfc\uc815\uc5d0\uc11c \ubd84\uc790\uc758 \uc804\uc790 \uc0c1\ud0dc\ub294 \ubcc0\ud558\uc9c0 \uc54a\uc73c\uba70(\uc608: \uacf5\uc720 \uacb0\ud569\uc774 \ub04a\uc5b4\uc9c0\uac70\ub098 \uc0dd\uc131\ub418\uc9c0 \uc54a\uc74c), \ubd84\uc790 \uc5ed\ud559 \ud798\uc7a5 \ubaa8\ub378\uc774 \uc801\uc6a9\ub429\ub2c8\ub2e4. \uc18c\uc704 \ubd84\uc790 \uc5ed\ud559 \ud798\uc7a5\uc740 \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc758 \uc704\uce58 \uc5d0\ub108\uc9c0\uac00 \uae30\ud558\ud559\uc801 \uad6c\uc131(\uc989, \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc744 \uad6c\uc131\ud558\ub294 \ubaa8\ub4e0 \uc6d0\uc790\uc758 \uacf5\uac04 \uc88c\ud45c)\uc5d0 \uc758\uc874\ud558\ub294 \uac83\uc744 \ud45c\ud604\ud558\ub294 \uacbd\ud5d8\uc801 \uc218\ud559\uc801 \ud568\uc218\uc785\ub2c8\ub2e4(\uadf8\ub9bc 1A). \uc989, \uc6b0\ub9ac\uac00 <i><em>X<\/em><\/i> \ub97c \uc0ac\uc6a9\ud558\uc5ec \ubaa8\ub4e0 \uc6d0\uc790\uc758 \uacf5\uac04 \uc88c\ud45c\ub97c \ub098\ud0c0\ub0b4\uace0 <i><sup><em>VMM<\/em><\/sup><\/i> <i><em><strong>(X<\/strong><\/em><\/i> )\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubd84\uc790\ub825\uc7a5 \ud3ec\ud150\uc15c \uc5d0\ub108\uc9c0\ub97c \ub098\ud0c0\ub0b4\uba70, \ubd84\uc790\uac00 \ud55c \ud615\ud0dc\uc5d0\uc11c \ub2e4\ub978 \ud615\ud0dc\ub85c \ubcc0\ud654\ud568\uc5d0 \ub530\ub77c \ud3ec\ud150\uc15c \uc5d0\ub108\uc9c0\uac00 \ubcc0\ud654\ud569\ub2c8\ub2e4. <sub>X1<\/sub> \ub2e4\ub978 <sub>X2<\/sub>:<br \/>\n<i><sup><em>\u2206VMM<\/em><\/sup><\/i> = <i><sup><em>VMM<\/em><\/sup><\/i> ( <sub>X2<\/sub> ) &#8211; <i><sup><em>VMM<\/em><\/sup><\/i> ( <sub>X1<\/sub> ).<br \/>\n\uc5f4\uc5ed\ud559 \uc774\ub860\uc5d0 \ub530\ub974\uba74 \ubd84\uc790\uc758 \uc6d0\uc790\ub294 \ud56d\uc0c1 \uc5f4 \uc6b4\ub3d9\uc744 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4, <i><em>X<\/em><\/i> \ub294 \uc2dc\uac04\uc5d0 \ub530\ub77c \ub04a\uc784\uc5c6\uc774 \ubcc0\ud654\ud558\uba70, \uc2e4\ud5d8 \uad00\ucc30\uc744 \ud560 \ub54c \uc2dc\ub8cc\ub294 \ud56d\uc0c1 \uc5ec\ub7ec \ubd84\uc790\ub85c \uad6c\uc131\ub418\uba70(\ub2e8\uc77c \ubd84\uc790 \uc2e4\ud5d8 \uc81c\uc678), \uc11c\ub85c \ub2e4\ub978 \ud615\ud0dc \uc0c1\ud0dc\uc758 \ubd84\uc790\uac00 \uc874\uc7ac\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc6b4\ub3d9\ud559\uc801 \uad00\uc810\uc5d0\uc11c\ub294 \uc2dc\uac04\uc5d0 \ub530\ub978 \ud615\ud0dc \ubcc0\ud654\ub97c \uace0\ub824\ud574\uc57c \ud558\uace0, \uc5f4\uc5ed\ud559\uc801 \uad00\uc810\uc5d0\uc11c\ub294 \uc11c\ub85c \ub2e4\ub978 \ud615\ud0dc\ub97c \uac00\uc9c4 \ubd84\uc790\uc758 \ud655\ub960 \ubd84\ud3ec\ub97c \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4. \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158(MD)\uc740 \uc774\ub7ec\ud55c \ub450 \uac00\uc9c0 \uce21\uba74\uc758 \ud2b9\uc131\uc744 \uc870\uc0ac\ud560 \uc218 \uc788\ub294 \uac00\uc7a5 \uac04\ub2e8\ud55c \ubaa8\ub378\uc785\ub2c8\ub2e4(\uadf8\ub9bc 1B). MD \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c\ub294 \ucd08\uae30 \ud615\ud0dc\uc5d0\uc11c \uc2dc\uc791\ud558\uc5ec \ud604\uc7ac \ud615\ud0dc\uc640 \uc704\uce58 \uc5d0\ub108\uc9c0 \ud568\uc218(\ud798\uc740 \uc6d0\uc790\uc758 \uc88c\ud45c\uc5d0 \ub300\ud55c \uc704\uce58 \uc5d0\ub108\uc9c0 \ud568\uc218\uc758 \uc74c\uc758 \ubbf8\ubd84)\ub97c \uae30\ubc18\uc73c\ub85c \uac01 \uc2dc\uc810\uc758 \uac01 \uc6d0\uc790\uc5d0 \uc791\uc6a9\ud558\ub294 \ud798\uc744 \uacc4\uc0b0\ud558\uace0, \ub274\ud134\uc758 \uc6b4\ub3d9 \ubc29\uc815\uc2dd\uc744 \uc218\uce58\uc801\uc73c\ub85c \ud1b5\ud569\ud558\uc5ec \ub2e4\uc74c \uc2dc\uc810\uc758 \ud615\ud0dc\ub97c \uad6c\ud55c \ud6c4 \uc774 \uacfc\uc815\uc744 \ubc18\ubcf5\ud558\uc5ec \uc2dc\uac04\uc5d0 \ub530\ub978 \ud615\ud0dc \ubcc0\ud654\uc758 \uada4\uc801\uc744 \uc5bb\uc2b5\ub2c8\ub2e4.<br \/>\n\uadf8 \uc0ac\uc774\uc5d0 \ud2b9\uc218 \uc54c\uace0\ub9ac\uc998\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud658\uacbd \uc694\uc778(\uc608: \uc628\ub3c4, \uc555\ub825 \ub4f1)\uc774 \ubd84\uc790 \uc6b4\ub3d9\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc2dc\ubbac\ub808\uc774\uc158\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5f4\uc5ed\ud559\uc801 \uc6d0\ub9ac\uc5d0 \ub530\ub974\uba74 \uc2dc\uac04 \uac04\uaca9\uc774 \ucda9\ubd84\ud788 \uae38\uba74 \uc11c\ub85c \ub2e4\ub978 \uc2dc\uc810\uc5d0\uc11c \ub3d9\uc77c\ud55c \ubd84\uc790\uc758 \ud615\ud0dc\uc640 \uc5f4\uc5ed\ud559\uc801 \ud3c9\ud615 \uc0c1\ud0dc\uc758 \ub2e4\ub978 \ubd84\uc790\uc758 \ud615\ud0dc \ud655\ub960 \ubd84\ud3ec\uac00 \ub3d9\uc77c\ud569\ub2c8\ub2e4(\uc989, \uc2dc\uac04 \ud3c9\uade0\uc740 \uc2dc\uc2a4\ud15c \ud3c9\uade0\uacfc \ub3d9\uc77c\ud569\ub2c8\ub2e4). \ub530\ub77c\uc11c MD \uc2dc\ubbac\ub808\uc774\uc158\uc744 \ucda9\ubd84\ud788 \uc624\ub79c \uc2dc\uac04 \ub3d9\uc548 \uc218\ud589\ud558\uba74 \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c \uc5bb\uc740 \uc77c\ub828\uc758 \ud615\ud0dc\ub97c \ud2b9\uc815 \uc5f4\uc5ed\ud559\uc801 \ud3c9\ud615 \uc0c1\ud0dc\uc5d0\uc11c\uc758 \ubd84\uc790 \ud615\ud0dc \ubd84\ud3ec\uc758 \uc0d8\ud50c\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc6d0\ub9ac\ub97c \ubc14\ud0d5\uc73c\ub85c MD\uc5d0\uc11c \uc5bb\uc740 \uc2dc\uac04 \uada4\uc801\uc744 \uae30\ubc18\uc73c\ub85c \uc5f4\uc5ed\ud559\uc801 \ud3c9\ud615 \uc0c1\ud0dc\uc5d0\uc11c \uc2dc\uc2a4\ud15c\uc758 \uc784\uc758\uc758 \uad00\ucc30 \uac00\ub2a5\ud55c \ud2b9\uc131\uc744 \ubd84\uc11d\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\nMD\ub294 \ud615\ud0dc \ubcc0\ud654\uc758 \uc6b4\ub3d9\ud559\uc801 \ubcc0\ud654 \uacfc\uc815\uacfc \uc911\uc694\ud55c \ubbf8\uc2dc\uc801 \uc591\uc790 \uc5f4\uc5ed\ud559\uc801 \ubd84\ud3ec\ub97c \uc6d0\uc790 \ud574\uc0c1\ub3c4\uc5d0\uc11c \uc885\ud569\uc801\uc73c\ub85c \ubd84\uc11d\ud560 \uc218 \uc788\ub294 \uac15\ub825\ud55c \uacc4\uc0b0 \ub3c4\uad6c\ub97c \uc81c\uacf5\ud558\uba70, \uc774\ub294 \ud6a8\uc18c\uc640 \uac19\uc740 \ubcf5\uc7a1\ud55c \uc0dd\uccb4 \uac70\ub300 \ubd84\uc790 \uae30\uacc4\uc758 \uc124\uacc4 \uc6d0\ub9ac\uc640 \uc791\ub3d9 \uba54\ucee4\ub2c8\uc998\uc744 \ubc1d\ud788\ub294 \ub370 \ud2b9\ud788 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \ud604\uc7ac \uace0\ubd84\uc790 \uad6c\uc870 \ubd84\uc11d\uc744 \uc704\ud55c \uc2e4\ud5d8\uc801 \ubc29\ubc95\uc740 \uc2dc\uacf5\uac04\uc801\uc73c\ub85c \ud3c9\uade0\ud654\ub41c \uc815\uc801 \uad6c\uc870\ub9cc\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0, MD \uc2dc\ubbac\ub808\uc774\uc158\uc740 \uad00\ub828 \uc5f0\uad6c\uc5d0\uc11c \ub300\uccb4 \ubd88\uac00\ub2a5\ud55c \uae30\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc804\uc81c \ud558\uc5d0 MD \ub3c4\uad6c \uc790\uccb4\ub294 \uc5ec\uc804\ud788 \uc9c0\uc18d\uc801\uc778 \uac1c\uc120\uacfc \uac1c\uc120\uc758 \uacfc\uc815\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \ubc29\ubc95\ub860\uc801\uc73c\ub85c MD\uc758 \uc8fc\uc694 \ud55c\uacc4\ub294 \uccab\uc9f8, \ubd84\uc790\ub825\uc7a5 \ubaa8\ub378\uc758 \uc815\ud655\uc131, \ub458\uc9f8, \uc81c\ud55c\ub41c \uc2dc\ubbac\ub808\uc774\uc158 \uc2dc\uac04\uc73c\ub85c \uc778\ud574 \ud615\ud0dc \uacf5\uac04\uc758 \uc804\uccb4 \uc0d8\ud50c\ub9c1\uc744 \uc2e4\ud604\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \ub450 \uac00\uc9c0 \uce21\uba74\uc5d0\uc11c \ube44\ub86f\ub429\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ubb38\uc81c\uc758 \uacbd\uc6b0, \ubd84\uc790\ub825\uc7a5\uc740 \ucd5c\uadfc \uba87 \ub144 \ub3d9\uc548 \ud06c\uac8c \uac1c\uc120\ub418\uc5b4 \uc0dd\ubb3c\ud559\uc801 \uac70\ub300 \ubd84\uc790, \ud2b9\ud788 \ub2e8\ubc31\uc9c8 \uc2dc\uc2a4\ud15c\uc758 \ud615\ud0dc \ud3c9\ud615\uc5d0 \ub300\ud55c \uc5f4\uc5ed\ud559\uc801 \uc124\uba85\uc758 \uc815\ud655\ub3c4\uac00 \ud5a5\uc0c1\ub418\uc5b4 \ud5e4\ub4dc \ud3f4\ub529 \uacfc\uc815\uc5d0\uc11c \uc790\uc5f0 \uad6c\uc870\uc5d0 \uc774\ub974\uae30\uae4c\uc9c0 \ub2e4\uc591\ud55c \ub2e8\ubc31\uc9c8 \ubd84\uc790\ub97c \uc131\uacf5\uc801\uc73c\ub85c \uc2dc\ubbac\ub808\uc774\uc158\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. <sup>[15-16].<\/sup> \uc2dc\ubbac\ub808\uc774\uc158 \uc2dc\uac04\uc758 \uacbd\uc6b0, \ucef4\ud4e8\ud130 \ud558\ub4dc\uc6e8\uc5b4 \ubc0f \uc18c\ud504\ud2b8\uc6e8\uc5b4\uc758 \ubc1c\ub2ec\ub85c \uc778\ud574 \uae30\uc874 \ucef4\ud4e8\ud305 \ud558\ub4dc\uc6e8\uc5b4(\uc608: \uadf8\ub8f9\uc5d0\uc11c \uc0ac\uc6a9\ud558\ub294 \uba40\ud2f0\ucf54\uc5b4 \uc11c\ubc84)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc77c\ubc18\uc801\uc778 \ud06c\uae30\uc758 \uc2dc\uc2a4\ud15c(\uc608: \uc218\uc6a9\uc561 \ub0b4 \uc218\ubc31 \uac1c\uc758 \uc794\uae30\ub85c \uc774\ub8e8\uc5b4\uc9c4 \ud6a8\uc18c \ubd84\uc790)\uc5d0 \ub300\ud574 \ub9c8\uc774\ud06c\ub85c\ucd08 \ub2e8\uc704\ub85c \uc2dc\ubbac\ub808\uc774\uc158\uc744 \uc218\ud589\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc2dc\uac04 \uaddc\ubaa8\uc5d0\uc11c\ub294 \uad6c\uc870 \ub3c4\uba54\uc778\uc774\ub098 \uace0\ub9ac \uc601\uc5ed\uc758 \uac1c\ubc29 \ubc0f \ud3d0\uc1c4\uc640 \uac19\uc740 \uacfc\uc815\uc744 \uad00\ucc30\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub354 \ub9ce\uc740 \ucef4\ud4e8\ud305 \ub9ac\uc18c\uc2a4\ub97c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub2e4\uba74 \uae30\ud310 \uacb0\ud569\/\ud574\uccb4\uc640 \uac19\uc740 \ud504\ub85c\uc138\uc2a4\ub97c \uc9c1\uc811 \uc2dc\ubbac\ub808\uc774\uc158\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uc2dc\ubbac\ub808\uc774\uc158\uc774 \ub3c4\ub2ec\ud560 \uc218 \uc5c6\ub294 \uc2dc\uac04 \uaddc\ubaa8(\uc608: \uc54c\ub85c\uc2a4\ud14c\ub9ad \ub2e8\ubc31\uc9c8\uc758 \ub300\uaddc\ubaa8 \uae30\ub2a5 \ubcc0\ud654 \ub4f1)\uc758 \ud504\ub85c\uc138\uc2a4\ub97c \uc5f0\uad6c\ud558\ub824\uba74 \ud5a5\uc0c1\ub41c \uc0d8\ud50c\ub9c1 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[17],<\/sup> \uc0ac\uc6a9\uc790\uac00 MD \uc774\ub860\uc5d0 \ub300\ud574 \ub354 \uae4a\uc774 \uc774\ud574\ud558\uace0 \uc788\ub2e4\ub294 \uc804\uc81c\ud558\uc5d0 \ub9d0\uc774\uc8e0.<br \/>\n\ud604\uc7ac \ub300\ubd80\ubd84\uc758 MD \uc2dc\ubbac\ub808\uc774\uc158 \uc560\ud50c\ub9ac\ucf00\uc774\uc158\uc740 \ub098\ub178\ucd08\uc5d0\uc11c \ub9c8\uc774\ud06c\ub85c\ucd08\uae4c\uc9c0\uc758 \uc2dc\uac04 \ubc94\uc704\ub97c \ub2e4\ub8e8\uba70, \ud615\ud0dc \uacf5\uac04\uc758 \uc0d8\ud50c\ub9c1\uc740 \ub300\ubd80\ubd84 \ucd08\uae30 \uad6c\uc870 \ubd80\uadfc\uc73c\ub85c \uc81c\ud55c\ub429\ub2c8\ub2e4(\ub2e8\uc77c \ub3c4\uba54\uc778 \ub2e8\ubc31\uc9c8\uc758 \uacbd\uc6b0 \uc77c\ubc18\uc801\uc73c\ub85c 3-4\u00c5 \ubc94\uc704\uc5d0\uc11c \ub8e8\ud2b8-\ud3c9\uade0 \uc81c\uacf1(RMS) \ubcc0\uc704\uc758 \uad6c\uc870\uc801 \uc0c1\uc2b9\uacfc \ud558\uac15). \ub530\ub77c\uc11c \uc2dc\ubbac\ub808\uc774\uc158 \uacb0\uacfc\uac00 \uc758\ubbf8 \uc788\ub294 \uacb0\uacfc\ub97c \uc5bb\uc73c\ub824\uba74 \ud569\ub9ac\uc801\uc778 \ucd08\uae30 \uad6c\uc870\ub97c MD\uc5d0 \uc785\ub825\uc73c\ub85c \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4. \ub300\ubd80\ubd84\uc758 \uacbd\uc6b0 \uc2e4\ud5d8\uc801\uc73c\ub85c \uacb0\uc815\ub41c \uacb0\uc815 \uad6c\uc870 \ub610\ub294 \uc0c1\ub3d9 \ub2e8\ubc31\uc9c8\uc758 \ube44\uad50 \ubaa8\ub378\ub9c1\uc5d0 \uae30\ubc18\ud55c \uad6c\uc870\uac00 MD\uc758 \ucd08\uae30 \uad6c\uc870\ub85c \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ud6a8\uc18c-\uae30\uc9c8 \ubcf5\ud569\uccb4\ub97c \uc2dc\ubbac\ub808\uc774\uc158\ud560 \ub54c\ub294 \ubd84\uc790 \ub3c4\ud0b9\uc744 \uc0ac\uc6a9\ud558\uac70\ub098 \uacb0\uc815 \uad6c\uc870\uc758 \ub2e4\ub978 \uc791\uc740 \ubd84\uc790(\uc608: \uc5b5\uc81c\uc81c)\ub97c \uae30\uc9c8\ub85c \uc9c1\uc811 \ub300\uccb4\ud558\uc5ec \ube48 \ud6a8\uc18c \ub610\ub294 \ub2e4\ub978 \ubd84\uc790\uc640 \ubcf5\ud569\ub41c \ud6a8\uc18c\uc758 \uad6c\uc870\ub97c \uae30\ubc18\uc73c\ub85c \ubcf5\ud569\uccb4\uc758 \ucd08\uae30 \uad6c\uc870\ub97c \ubaa8\ub378\ub9c1\ud574\uc57c \ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. MD \uc2dc\ubbac\ub808\uc774\uc158\uc740 \ub610\ud55c \uc2dc\uc2a4\ud15c\uc758 \ubaa8\ub4e0 \ud654\ud559 \ub2e8\uc704\ub97c \ubb18\uc0ac\ud558\ub294 \ubd84\uc790\ub825\uc7a5\uc744 \uad6c\uc131\ud574\uc57c \ud569\ub2c8\ub2e4. \uc2dc\ubbac\ub808\uc774\uc158\ud560 \uc2dc\uc2a4\ud15c\uc5d0 \uae30\uc9c8\ub85c \uc791\uc740 \ubd84\uc790\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 \uacbd\uc6b0, MD \uc18c\ud504\ud2b8\uc6e8\uc5b4 \ud328\ud0a4\uc9c0\uc5d0\uc11c \uc81c\uacf5\ud558\ub294 \ud45c\uc900 \ubd84\uc790\ub825\uc7a5\uc774 \uae30\uc9c8\ub85c \uc791\uc740 \ubd84\uc790\ub97c \ud3ec\ud568\ud558\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uac00 \uc885\uc885 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacbd\uc6b0 \uc800\ubd84\uc790\uc5d0 \ub300\ud55c \ud3ec\uc2a4 \ud544\ub4dc\ub97c \uc790\ub3d9\uc73c\ub85c \uc0dd\uc131\ud560 \uc218 \uc788\ub294 \ub3c4\uad6c \uc18c\ud504\ud2b8\uc6e8\uc5b4\ub97c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[18-19].<\/sup> \uae34 MD \uc2dc\ubbac\ub808\uc774\uc158\uc5d0 \uc790\ub3d9 \uc0dd\uc131\ub41c \ud3ec\uc2a4 \ud544\ub4dc\ub97c \uc0ac\uc6a9\ud558\uae30 \uc804\uc5d0 \ud3ec\uc2a4 \ud544\ub4dc \ud30c\uc77c\uc744 \uc218\ub3d9\uc73c\ub85c \ud655\uc778\ud558\uc5ec \uc9e7\uc740 \uc2dc\ubbac\ub808\uc774\uc158 \uc2dc\ud5d8\uc5d0 \uc0ac\uc6a9\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n<p>\uadf8\ub9bc. <strong>1<\/strong> \ubd84\uc790 \uc5ed\ud559 \uc5ed\ud559 \ud544\ub4dc <strong>(A) \ubc0f<\/strong> \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158 <strong>(B)<\/strong><br \/>\n\uadf8\ub9bc 1 \ubd84\uc790 \uc5ed\ud559 \ud798\uc7a5(A) \ubc0f \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158(B)<\/p>\n<p>1.2<\/p>\n<p>\ud6a8\uc18c \uc5f0\uad6c\uc5d0 \uc801\uc6a9<\/p>\n<p>MD \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c \uc5bb\uc740 \uc815\ubcf4\ub97c \ub2e4\uc591\ud55c \ubc29\uc2dd\uc73c\ub85c \uc801\uc6a9\ud558\uc5ec \ud6a8\uc18c \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1 \uc218\uc815\uc744 \uc548\ub0b4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[20].<\/sup> \uc608\ub97c \ub4e4\uc5b4, \uc2e4\uc628\uacfc \uace0\uc628 MD \uc2dc\ubbac\ub808\uc774\uc158\uc744 \ube44\uad50\ud568\uc73c\ub85c\uc368 \ud6a8\uc18c \ubd84\uc790\uc758 \uc5b4\ub290 \uc601\uc5ed\uc774 \uc8fc\ubcc0 \uc628\ub3c4\uc5d0 \uac00\uc7a5 \ubbfc\uac10\ud55c \uad6c\uc870\uc801 \uc548\uc815\uc131\uc744 \uac00\uc9c8 \uac00\ub2a5\uc131\uc774 \ub192\uc740\uc9c0 \uc608\uce21\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc601\uc5ed\uc5d0 \ud504\ub864\ub9b0 \uc810 \ub3cc\uc5f0\ubcc0\uc774, \uc774\ud669\ud654 \uacb0\ud569 \ub4f1\uc744 \ub3c4\uc785\ud558\uba74 \uc7a0\uc7ac\uc801\uc73c\ub85c \ud6a8\uc18c\uc758 \ub0b4\uc5f4\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[21-24].<\/sup> \uc548\uc815\uc131\uc744 \uac1c\uc120\ud558\uae30 \uc704\ud55c \ub610 \ub2e4\ub978 \uc804\ub7b5\uc740 \ud45c\uba74 \uc218\uc18c\uc640 \uc5fc \uacb0\ud569\uc744 \ub354 \ub9ce\uc774 \ud615\uc131\ud558\ub294 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc124\uacc4\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. <sup>[25-26].<\/sup> \uc774\ub7ec\ud55c \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc2e4\ud5d8\uc801\uc73c\ub85c \uac80\uc99d\ud558\uae30 \uc804\uc5d0 \uc57c\uc0dd\ud615\uacfc \ub3cc\uc5f0\ubcc0\uc774\ub97c \ub3d9\uc2dc\uc5d0 \uc2dc\ubbac\ub808\uc774\uc158\ud558\uc5ec \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc6d0\ud558\ub294 \ud6a8\uacfc\ub97c \uc5bb\uc744 \uc218 \uc788\ub294\uc9c0 \uc774\ub860\uc801\uc73c\ub85c \ud3c9\uac00\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[27-28].<\/sup> MD\ub294 \uc628\ub3c4 \uc678\uc5d0\ub3c4 \ud658\uacbd pH, \uc6a9\ub9e4 \ub4f1\uc758 \ubcc0\ud654\uac00 \ub2e8\ubc31\uc9c8 \ud615\ud0dc\uc640 \uc548\uc815\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubd84\uc11d\ud558\ub294 \ub370 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[29-30].<\/sup><br \/>\n\uc548\uc815\uc131 \uc678\uc5d0\ub3c4 MD\ub294 \uae30\uc9c8 \uacb0\ud569\/\uc0dd\uc0b0\ubb3c \ubc29\ucd9c\uacfc \uad00\ub828\ub41c \ud615\ud0dc \uc5ed\ud559\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce60 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \ud56b\uc2a4\ud31f \uc794\uae30\ub97c \uc608\uce21\ud558\ub294 \ub370 \uc801\uc6a9\ub418\uc5b4 \uae30\uc9c8 \uc120\ud0dd\uc131, \ubc18\uc751 \uc120\ud0dd\uc131, \uc81c\ud488 \ubc29\ucd9c \uc18d\ub3c4 \ub4f1\uc744 \ubcc0\uacbd\ud560 \uc218 \uc788\ub294 \ub3cc\uc5f0\ubcc0\uc774 \ub610\ub294 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \uc124\uacc4\ud560 \uc218 \uc788\ub294 \uae30\ubc18\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. <sup>[31-32].<\/sup> MD\ub85c \uae30\uc9c8\/\ubc18\uc751 \uc120\ud0dd\uc131\uc744 \uc5f0\uad6c\ud558\ub294 \ubc29\ubc95 \uc911 \ud558\ub098\ub294 \uc11c\ub85c \ub2e4\ub978(\ucd08\uae30 \uad6c\uc870) \ud6a8\uc18c-\uae30\uc9c8 \ubcf5\ud569\uccb4\uc758 \uc2dc\ubbac\ub808\uc774\uc158 \uacb0\uacfc\ub97c \ube44\uad50\ud558\uc5ec \ub354 \ub192\uc740 \uce5c\ud654\ub3c4(\ub610\ub294 \ub354 \ub192\uc740 \ubc18\uc751\uc131)\ub97c \uac16\ub294 \uae30\uc9c8 \ub610\ub294 \uad6c\uc870 \uc0c1\ud0dc\ub97c \uc608\uce21\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uce5c\ud654\ub3c4(\ub610\ub294 \ubc18\uc751\uc131)\ub97c \uacc4\uc0b0\ud558\ub294 \uc5c4\uaca9\ud55c \uc815\ub7c9\uc801 \ubc29\ubc95\uc740 \uc790\uc720 \uc5d0\ub108\uc9c0 \uacc4\uc0b0\uc785\ub2c8\ub2e4. <sup>[33-34].<\/sup> \uc790\uc720 \uc5d0\ub108\uc9c0 \uacc4\uc0b0\uc758 \uacc4\uc0b0 \uc9d1\uc57d\uc801\uc778 \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \ud604\uc7ac \ub300\ubd80\ubd84\uc758 \uc751\uc6a9 \ubd84\uc57c\uc5d0\uc11c\ub294 \uc0c1\ub300\uc801 \uce5c\ud654\ub3c4\uc758 \uc815\uc131\uc801 \ud310\ubcc4\uc740 \uc800\ubd84\uc790-\uac70\ub300 \ubd84\uc790 \ubcf5\ud569\uccb4\uc758 \uad6c\uc870 \uc548\uc815\uc131, \ud3c9\uade0 \ubd84\uc790 \uac04 \uc0c1\ud638\uc791\uc6a9 \uc5d0\ub108\uc9c0 \ub4f1\uc744 \uae30\ubc18\uc73c\ub85c \ud558\uba70, \ubc18\uc751\uc131\uc758 \uc815\uc131\uc801 \ud310\ubcc4\uc740 \ucd09\ub9e4 \ubc0f \ubc18\uc751 \uc791\uc6a9\uae30 \ub4f1\uc758 \uc0c1\ub300\uc801 \uae30\ud558\ud559\uc801 \uad6c\uc131 \ubd84\ud3ec \ub4f1\uc744 \uae30\ubc18\uc73c\ub85c \ud569\ub2c8\ub2e4. <sup>[35].<\/sup> \uc774\ub7ec\ud55c \uc9c8\uc801 \ucc28\ubcc4\uc758 \uacb0\uacfc\ub294 \uc9c0\uc2dc\ub41c \uc9c4\ud654 \uc11c\uc5f4\uc758 \ub77c\uc774\ube0c\ub7ec\ub9ac\ub97c \uc124\uacc4\ud558\uae30 \uc704\ud55c \uae30\ucd08\ub85c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c MD \uc2dc\ubbac\ub808\uc774\uc158\uc740 \uae30\uc9c8 \uacb0\ud569\/\uc0b0\ubb3c \ud574\ub9ac \uae30\uacf5 \uc8fc\ubcc0\uc758 \ud56b\uc2a4\ud31f \uc794\ub958\ubb3c\uc744 \ubd84\uc11d\ud558\ub294 \ub370\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[36-37].<\/sup> \uc774\ub7ec\ud55c \uc720\ud615\uc758 \uc751\uc6a9 \ubd84\uc57c\uc5d0\ub294 \ub2e8\ubc31\uc9c8\uc5d0\uc11c \uc800\ubd84\uc790\ub97c \ubd84\ub9ac\ud558\uae30 \uc704\ud55c \ud574\ub9ac \uacbd\ub85c \uc2dc\ubbac\ub808\uc774\uc158\uc774 \ud3ec\ud568\ub418\uba70, \uc2dc\ubbac\ub808\uc774\uc158 \uc2dc\uac04 \uaddc\ubaa8\uac00 \ucda9\ubd84\ud558\uc9c0 \uc54a\uc544 \uc5b4\ub824\uc6c0\uc774 \uc788\ub294 \uacbd\uc6b0 \ud5a5\uc0c1\ub41c \uc0d8\ud50c\ub9c1 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc774\ub97c \uadf9\ubcf5\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[38-39].<\/sup><\/p>\n<p>2<\/p>\n<p>\uc591\uc790\uc5ed\ud559(QM) \ubc0f \uc591\uc790\uc5ed\ud559\/\ubd84\uc790 \uc5ed\ud559 \uacb0\ud569(QM\/MM) \ubaa8\ub378<\/p>\n<p>2.1<\/p>\n<p>\ubc29\ubc95 \uc18c\uac1c<\/p>\n<p>\uacf5\uc720 \uacb0\ud569 \uc0dd\uc131 \ubc0f \ud30c\uad34, \uc804\uc790 \uc774\ub3d9, \uc11c\ub85c \ub2e4\ub978 \uc804\uc790 \uc0c1\ud0dc \uc0ac\uc774\uc758 \ub3c4\uc57d\uacfc \uac19\uc740 \ud6a8\uc18c \ucd09\ub9e4\uc758 \ud654\ud559\uc801 \ub2e8\uacc4\ub97c \uc2dc\ubbac\ub808\uc774\uc158\ud558\ub824\uba74 \uc591\uc790 \uc5ed\ud559(QM) \ubaa8\ub378\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \ud604\uc7ac \uacc4\uc0b0 \ud654\ud559\uc5d0\uc11c \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 QM \ubaa8\ub378\uc740 \ub2e4\uc74c\uacfc \uac19\uc740 \uba87 \uac00\uc9c0 \uc720\ud615\uc73c\ub85c \ubd84\ub958\ub429\ub2c8\ub2e4. <i><em>\ucc98\uc74c \uc2dc\uc791<\/em><\/i> ), \ubc00\ub3c4-\ud568\uc218 \uc774\ub860(DFT) \ubc0f \ubc18\uacbd\ud5d8\uc801 \ubc29\ubc95 <sup>[40].<\/sup> \uadf8 \uc911 \ubc18\uacbd\ud5d8\uc801 \ubc29\ubc95\uc740 \uacc4\uc0b0 \ube44\uc6a9\uc774 \uac00\uc7a5 \uc801\uac8c \ub4ed\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc81c1\uc6d0\uce59\uc774 \uc544\ub2cc \ubc29\ubc95\uc774\uba70 \uacc4\uc0b0 \uacb0\uacfc\uc758 \uc2e0\ub8b0\uc131\uc740 \ud2b9\uc815 \uc2dc\uc2a4\ud15c\uacfc \ubb38\uc81c\uc5d0 \ub530\ub77c \ud06c\uac8c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \uc560\ube44\ub2c8\uc624 \ubc29\ubc95\uacfc DFT \ubc29\ubc95 \ubaa8\ub450 \uc81c1\uc6d0\ub9ac \ubc29\ubc95\uc774\uba70 \ubcf4\ud3b8\uc801\uc778 \ubc29\ubc95\uc785\ub2c8\ub2e4. \uc2e4\uc81c DFT \ubaa8\ub378\uc740 \ucd08\uae30 \uacc4\uc0b0\ubcf4\ub2e4 \uacbd\ud5d8\uc801\uc778 \uc774\ub860\uc801 \uadfc\uc0ac\uce58\ub97c \ub354 \ub9ce\uc774 \ud3ec\ud568\ud560 \uc218 \uc788\uc9c0\ub9cc, DFT\ub294 \ub9e4\uc6b0 \ub192\uc740 \uacc4\uc0b0 \ud6a8\uc728\ub85c \uc804\uc790 \uc0c1\uad00 \uc5d0\ub108\uc9c0\ub97c \ucc98\ub9ac\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ub9ce\uc740 \ud654\ud559 \ubc18\uc751 \ubb38\uc81c\uc758 \uacbd\uc6b0 \ubc18\uc751 \uacfc\uc815 \uc911 \uc5d0\ub108\uc9c0 \ubcc0\ud654\uc640 \uac19\uc740 \uc8fc\uc694 \ud30c\ub77c\ubbf8\ud130\uc5d0 \ub300\ud55c \ucd5c\uc0c1\uc758 DFT \ubaa8\ub378\uc758 \uacc4\uc0b0 \uc624\ucc28\ub294 \uc774\ubbf8 \uc57d 1kcal\/mol \uc815\ub3c4\ub85c \uc791\uc73c\uba70, \uadf8 \uacb0\uacfc\ub294 \ud2b9\uc815 \ucd09\ub9e4 \uba54\ucee4\ub2c8\uc998\uc774\ub098 \ubc18\uc751 \uacbd\ub85c\uc758 \ud654\ud559\uc801 \uac74\uc804\uc131\uc744 \uacb0\uc815\ud558\uae30 \uc704\ud55c \uae30\ucd08\ub85c \uc0ac\uc6a9\ud558\uae30\uc5d0 \ucda9\ubd84\ud569\ub2c8\ub2e4.<br \/>\n\ubd84\uc790\uc758 \uae30\ud558\ud559\uc801 \uad6c\uc131\uc774 \uc8fc\uc5b4\uc9c0\uba74 QM\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5d0\ub108\uc9c0\ub97c \uacc4\uc0b0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \ub2e8\uc77c\uc810 \uacc4\uc0b0(\uc989, \uae30\ud558\ud559\uc801 \uad6c\uc131 \uacf5\uac04\uc5d0\uc11c \ud55c \uc810\ub9cc \ub2e4\ub8e8\ub294 \uacc4\uc0b0)\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. QM \ubaa8\ub378\uc740 \ubd84\uc790 \uad6c\uc870\uc758 \ucd5c\uc801\ud654, \uc989 \ucd08\uae30 \uad6c\uc131\uc5d0\uc11c \uc5f0\uc18d\uc801\uc778 \ubcc0\ud654 \ud6c4 \uad6d\ubd80\uc801\uc73c\ub85c \uc548\uc815\uc801\uc778 \uad6c\uc870(\uc8fc\ubcc0 \uad6c\uc870\ubcf4\ub2e4 \ub0ae\uc740 \uc5d0\ub108\uc9c0)\ub97c \ucc3e\uac70\ub098 \ubc18\uc751\ubb3c\uacfc \uc0dd\uc131\ubb3c\uc744 \uc5f0\uacb0\ud558\ub294 \uac00\uc7a5 \ub0ae\uc740 \uc5d0\ub108\uc9c0 \uacbd\ub85c\uc640 \uacbd\ub85c\ub97c \ub530\ub77c \uc804\uc774 \uc0c1\ud0dc\ub97c \ucc3e\ub294 \ub370 \ub354 \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacc4\uc0b0\uc740 \ub2e4\uc591\ud55c \uae30\ud558\ud559\uc801 \uad6c\uc131\uc744 \uace0\ub824\ud558\uace0 \ube44\uad50\ud574\uc57c \ud558\uba70 \uc77c\ubc18\uc801\uc73c\ub85c \uc218\uc2ed\uc5d0\uc11c \uc218\ucc9c \uac1c\uc758 \ub2e8\uc77c \uc9c0\uc810 \uacc4\uc0b0\uc744 \uc218\ud589\ud574\uc57c \ud558\ubbc0\ub85c \uacc4\uc0b0 \uc9d1\uc57d\uc801\uc785\ub2c8\ub2e4. \uacc4\uc0b0 \ub178\ub825\uc744 \uc808\uc57d\ud558\uae30 \uc704\ud55c \uc77c\ubc18\uc801\uc778 \uc804\ub7b5\uc740 \uba3c\uc800 \uc815\ud655\ub3c4\uac00 \uc81c\ud55c\ub41c \ud6a8\uc728\uc801\uc778 QM \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud558\uc5ec \uad11\ubc94\uc704\ud55c \ubc18\uc751 \uacbd\ub85c \uac80\uc0c9\uc744 \ucd5c\uc801\ud654\ud55c \ub2e4\uc74c, \uac80\uc0c9\ub41c \uac00\uc7a5 \ub0ae\uc740 \uc5d0\ub108\uc9c0 \uad6c\uc131\/\uacbd\ub85c \uadfc\ucc98\uc5d0\uc11c \uc815\ud655\ub3c4\uac00 \ub192\uc740 \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud558\uc5ec \uad6c\uc131 \ucd5c\uc801\ud654\ub97c \uc644\ub8cc\ud558\uac70\ub098 \ub2e8\uc77c \uc9c0\uc810 \uacc4\uc0b0\uc744 \uc218\ud589\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.<br \/>\n\ud604\uc7ac \ud6a8\uc18c \ubd84\uc790 \uc804\uccb4\uc5d0 \uc81c1\uc6d0\ub9ac QM \ubc29\ubc95\uc744 \uc801\uc6a9\ud558\ub294 \uac83\uc740 \uacc4\uc0b0 \uc9d1\uc57d\uc801\uc774\uba70 \uae30\ubcf8\uc801\uc73c\ub85c \ub2e8\uc77c \uc9c0\uc810 \uacc4\uc0b0\uc73c\ub85c \uc81c\ud55c\ub418\uba70 \uc5ec\uc804\ud788 \uc2e4\uc6a9\uc131\uc774 \ubd80\uc871\ud569\ub2c8\ub2e4. QM\/MM \ubaa8\ub378(\uadf8\ub9bc 2)\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ud070 \ubd84\uc790\uc5d0 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. <sup>[11].<\/sup> \uc774 \ubaa8\ub378\uc5d0\uc11c \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc740 \uc801\uc5b4\ub3c4 \ub450 \ubd80\ubd84\uc73c\ub85c \ub098\ub258\ub294\ub370, \ud654\ud559 \ubc18\uc751\uc5d0 \uc9c1\uc811 \uad00\uc5ec\ud558\ub294 \ubd80\ubd84\uc740 QM \ubaa8\ub378\ub85c \ucc98\ub9ac\ud558\uace0 \ub098\uba38\uc9c0\ub294 \ubd84\uc790 \uc5ed\ud559(MM)\uc73c\ub85c \ucc98\ub9ac\ud569\ub2c8\ub2e4. QM-MM \uacbd\uacc4\uc640 \uc0c1\ud638\uc791\uc6a9\uc744 \ucc98\ub9ac\ud558\ub294 \uba87 \uac00\uc9c0 \ub2e4\ub978 \uc804\ub7b5\uc774 \uc788\uc2b5\ub2c8\ub2e4. <sup>[41].<\/sup> \uc81c1\uc6d0\ub9ac QM\/MM \ubaa8\ub378\uc5d0\uc11c QM \uacc4\uc0b0\uc740 MM\ubcf4\ub2e4 \ud6e8\uc52c \ub354 \ub9ce\uc740 \ube44\uc6a9\uc774 \ub4e4\uae30 \ub54c\ubb38\uc5d0, \uc8fc\ub85c QM \uc601\uc5ed\uc758 \ud615\uc0c1\uc744 \uc608\uce21\ud558\uac70\ub098 \uc2dc\ubbac\ub808\uc774\uc158\ud558\uae30 \uc704\ud574 \ud615\ud0dc \ucd5c\uc801\ud654 \ubc29\ubc95\uc774 \uc0ac\uc6a9\ub418\uba70, \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158\uc744 \uc0ac\uc6a9\ud558\uc5ec MM \ubd80\ubd84\uc744 \uc0d8\ud50c\ub9c1\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[42].<\/sup> \uc774\ub294 \uacc4\uc0b0 \uacb0\uacfc\uac00 \uc2dc\uc2a4\ud15c\uc758 QM \uc601\uc5ed\uc758 \ucd08\uae30 \uad6c\uc870\uc5d0 \ub354 \ubbfc\uac10\ud560 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \uc774 \uacbd\uc6b0 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uacb0\uacfc\ub97c \uc5bb\uc73c\ub824\uba74 \ub2e4\ub978 \ucd08\uae30 \uad6c\uc870 \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud55c \uacc4\uc0b0\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \ubc18\uacbd\ud5d8\uc801 \ubc29\ubc95\uc758 \uacbd\uc6b0 <sup>[43] \ub610\ub294<\/sup> \uacbd\ud5d8\uc801 \uc6d0\uc790\uac00 \uacb0\ud569 \uc774\ub860 <sup>[44-45]<\/sup> \ub294 QM \ud30c\ud2b8\uc5d0 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. <sup>,<\/sup> \ub97c \uc0ac\uc6a9\ud558\uba74 \ub354 \uae34 QM\/MM MD \uc0d8\ud50c\ub9c1\uc744 \ud1b5\ud574 \ud615\ud0dc \uacf5\uac04\uc744 \ub354 \uc644\ubcbd\ud558\uac8c \ud0d0\uc0c9\ud558\uace0 \ucd08\uae30 \uad6c\uc870\uc758 \uc601\ud5a5\uc744 \uc904\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uadf8\ub9bc. <strong>2 <\/strong> \uc591\uc790 \uae30\uacc4 <strong>(QM)\/\ubd84\uc790<\/strong> \uc5ed\ud559 <strong> (MM)<\/strong> \ubaa8\ub378<br \/>\n\uadf8\ub9bc 2 \uc591\uc790 \uc5ed\ud559(QM)\/\ubd84\uc790 \uc5ed\ud559(MM) \ubaa8\ub378.<\/p>\n<p>2.2<\/p>\n<p>\ubc29\ubc95 \uc801\uc6a9<\/p>\n<p><sup>\ub458 \ub2e4<\/sup> QM \ubaa8\ub378 <sup>[10] \ubc0f<\/sup> QM\/MM \ubaa8\ub378 <sup>[41]<\/sup> \ub294 \ud6a8\uc18c \ucd09\ub9e4 \ubc18\uc751\uc758 \ud654\ud559\uc801 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\ub860\uc801\uc73c\ub85c \uc608\uce21\ud558\uace0 \ud14c\uc2a4\ud2b8\ud558\ub294 \ub370 \ub110\ub9ac \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc\ub294 \ud654\ud559 \ubc18\uc751 \uacfc\uc815\uc5d0 \ucc38\uc5ec\ud558\ub294 \uc8fc\uc694 \uc794\ub958\ubb3c\uc744 \ud30c\uc545\ud558\uace0, \ubc18\uc751\uc758 \uc18d\ub3c4 \uc81c\ud55c \ub2e8\uacc4\ub97c \ucc3e\uace0, \ubc18\uc751 \uc911\uac04\uccb4\uc640 \uc804\uc774 \uc0c1\ud0dc\uc758 \uad6c\uc870\ub97c \ubaa8\ub378\ub9c1\ud558\uace0, \ud6a8\uc18c \ud658\uacbd\uacfc \uc5b4\ub5bb\uac8c \uc0c1\ud638\uc791\uc6a9\ud558\ub294\uc9c0 \ubd84\uc11d\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. QM \ud074\ub7ec\uc2a4\ud130 \ubaa8\ub378\uacfc \ube44\uad50\ud558\uc5ec QM\/MM \ubaa8\ub378\uc740 \ud654\ud559 \ubc18\uc751 \uc911\uc2ec\uc774 \uc704\uce58\ud55c \ud6a8\uc18c \ud658\uacbd\uc744 \ubcf4\ub2e4 \ud604\uc2e4\uc801\uc73c\ub85c \uc2dc\ubbac\ub808\uc774\uc158\ud560 \uc218 \uc788\uc73c\uba70, \ud6a8\uc18c \ucd09\ub9e4\uc758 \ud654\ud559 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\ub860\uc801\uc73c\ub85c \uc608\uce21\/\uc2dc\ud5d8\ud558\uace0 \ud658\uacbd \uc544\ubbf8\ub178\uc0b0 \uc794\uae30\uac00 \ucd09\ub9e4 \uacfc\uc815\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubd84\uc11d \ubc0f \uc608\uce21\ud558\ub294 \ub370 \ub110\ub9ac \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. <sup>[46].<\/sup> \uc6d0\uce59\uc801\uc73c\ub85c \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ucd09\ub9e4 \ud65c\uc131\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \ud2b9\uc774\uc131 \ub610\ub294 \uc120\ud0dd\uc131\uc744 \ubcc0\uacbd\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud558\ub294 \uc720\ub3c4 \uc9c4\ud654 \ub3cc\uc5f0\ubcc0\uc774 \ub77c\uc774\ube0c\ub7ec\ub9ac\uc758 \uc124\uacc4\ub97c \uc548\ub0b4\ud558\ub294 \ub370 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub354 \ub3c4\uc804\uc801\uc778 \uc5f0\uad6c\ub294 QM \ub610\ub294 QM\/MM \uc608\uce21 \uc804\uc774 \uc0c1\ud0dc \uad6c\uc870 \ubaa8\ub378\uc5d0\uc11c \ucc98\uc74c\ubd80\ud130 \uc0c8\ub85c\uc6b4 \ud65c\uc131 \uc911\uc2ec\uc744 \uc124\uacc4\ud558\uc5ec \uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \uc778\uacf5 \ud6a8\uc18c\ub97c \uc5bb\ub294 \uac83\uc785\ub2c8\ub2e4. <sup>[47].<\/sup><\/p>\n<p>3<\/p>\n<p>\uc815\uc804\uae30 \uc5f0\uc18d\uccb4 \ubbf8\ub514\uc5b4 \ubaa8\ub378\ub9c1<\/p>\n<p>3.1<\/p>\n<p>\ubc29\ubc95\uc758 \uc6d0\ub9ac<\/p>\n<p>\ud6a8\uc18c \ucd09\ub9e4 \uc791\uc6a9\uc740 \uac70\uc758 \ud56d\uc0c1 \ud2b9\uc815 \uc6a9\uc561 \ud658\uacbd\uc5d0\uc11c \uc774\ub8e8\uc5b4\uc9d1\ub2c8\ub2e4. \uc6a9\ub9e4 \ud6a8\uacfc\ub294 \ud6a8\uc18c\uc758 \ud2b9\uc131\uc5d0 \uacb0\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4. \ud654\ud559 \ucc98\ub9ac\uc758 \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \uacc4\uc0b0\ud558\ub294 \ubaa8\ub378\uc740 \ubd84\uc790 \uc5ed\ud559 \ud798\uc7a5 \ub610\ub294 QM \ubaa8\ub378\uacfc \uac19\uc774 \uac01 \uc6a9\ub9e4 \ubd84\uc790\uc640 \uadf8 \uc548\uc758 \uc6d0\uc790\uac00 \ubaa8\ub378\uc5d0 \uba85\uc2dc\uc801\uc73c\ub85c \ud3ec\ud568\ub418\ub294 \uba85\uc2dc\uc801 \uc6a9\ub9e4 \ubaa8\ub378\uacfc \uc554\uc2dc\uc801 \uc6a9\ub9e4 \ub610\ub294 \uc5f0\uc18d\uccb4 \ub9e4\uccb4 \ubaa8\ub378\uc758 \ub450 \uac00\uc9c0 \ubc94\uc8fc\ub85c \ub098\ub269\ub2c8\ub2e4. <sup>[48], \uc5ec\uae30\uc11c<\/sup> \uc6a9\ub9e4 \ubd84\uc790\uc640 \uc6d0\uc790\ub294 \ubaa8\ub378\uc5d0 \ud3ec\ud568\ub418\uc9c0 \uc54a\uace0 \uc18c\uc704 \"\uc6a9\ub9e4 \ud3c9\uade0\uc7a5\"\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \ucc98\ub9ac\ud569\ub2c8\ub2e4. \uc6a9\ub9e4 \ubd84\uc790\uc640 \uc6d0\uc790\ub294 \ud3ec\ud568\ub418\uc9c0 \uc54a\uace0 \uc18c\uc704 \"\uc6a9\ub9e4 \ud3c9\uade0\uc7a5\"\uc73c\ub85c \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \ucc98\ub9ac\ud569\ub2c8\ub2e4. \uba85\uc2dc\uc801 \uc6a9\ub9e4 \ubaa8\ub378\uc758 \uc7a5\uc810\uc740 \uc6a9\uc9c8\uacfc \uc6a9\ub9e4\ub97c \uc644\uc804\ud788 \uc77c\uad00\ub41c \ubc29\uc2dd\uc73c\ub85c \ucc98\ub9ac\ud558\uc5ec \uc6a9\uc9c8-\uc6a9\ub9e4 \uc218\uc18c \uacb0\ud569, \uc5fc \uacb0\ud569 \ub4f1\uacfc \uac19\uc740 \ud2b9\uc815 \uc0c1\ud638\uc791\uc6a9\uc744 \uc0ac\uc2e4\uc801\uc73c\ub85c \ubaa8\ub378\ub9c1\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ub2e8\uc810\uc740 \uc6a9\ub9e4 \ubd84\uc790\uc758 \uc218\uac00 \ub9ce\uace0 \uacc4\uc0b0 \uc9d1\uc57d\uc801\uc774\ub77c\ub294 \uc810\uc785\ub2c8\ub2e4. \ub610\ud55c \uc6a9\ub9e4 \ud655\ub960\uc801 \uc0c1\uc2b9\uc740 \uc2dc\uc2a4\ud15c\uc758 \ucd1d \uc5d0\ub108\uc9c0\uc5d0 \ud06c\uac8c \uae30\uc5ec\ud558\uba70, \uc0c1\uc2b9 \ud6a8\uacfc\ub97c \uc81c\uac70\ud558\ub824\uba74 \uae34 \uc2dc\ubbac\ub808\uc774\uc158 \uc0d8\ud50c \ud3c9\uade0\uc744 \uc218\ud589\ud574\uc57c \ud569\ub2c8\ub2e4. \uc228\uaca8\uc9c4 \uc6a9\ub9e4 \ubaa8\ub378\uc740 \uc6a9\ub9e4\uc758 \ud3c9\uade0\ud654 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b4\uba70, \uc6a9\ub9e4\uc758 \uc5f4\uc5ed\ud559\uc801 \uc0c1\uc2b9\uacfc \ud558\uac15\uc774 \ud3c9\uade0\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<br \/>\n\ucc98\ub9ac\uc758 \ub2e8\uc21c\ud654\ub97c \uc704\ud574 \uc77c\ubc18\uc801\uc73c\ub85c \uc228\uaca8\uc9c4 \uc6a9\ub9e4 \ubaa8\ub378\uc5d0\uc11c\ub294 \ube44\uadf9\uc131 \uc6a9\ub9e4 \ud6a8\uacfc(\uc18c\uc218\uc131 \ud6a8\uacfc)\ub97c \uadf9\uc131 \uc6a9\ub9e4 \ud6a8\uacfc\uc640 \ubd84\ub9ac\ud569\ub2c8\ub2e4. \uacbd\ud5d8\uc5d0 \ub530\ub974\uba74 \ube44\uadf9\uc131 \uc6a9\uc9c8\uc758 \uc6a9\ud574 \uc790\uc720 \uc5d0\ub108\uc9c0\ub294 \uc6a9\ub9e4 \uc811\uadfc \ud45c\uba74\uc801(SASA)\uc5d0 \ube44\ub840\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc774 \uad6c\uc131 \uc694\uc18c\uc5d0\ub294 SASA \uc6a9\ud574 \ubaa8\ub378\uc774 \uc790\uc8fc \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774 \ubaa8\ub378\uc758 \ud30c\ub77c\ubbf8\ud130\uc5d0\ub294 SASA\ub97c \uacc4\uc0b0\ud558\ub294 \ub370 \ud544\uc694\ud55c \uc6d0\uc790 \ubc18\uacbd, \uc6a9\ub9e4 \ubd84\uc790\uc758 \ubc18\uacbd(\ubb3c \ubd84\uc790\uc758 \uacbd\uc6b0 1.4\u00c5), SASA\uc5d0 \ube44\ub840\ud558\ub294 \uc6a9\ud574 \uc790\uc720 \uc5d0\ub108\uc9c0\uc758 \ube44\ub840 \uc0c1\uc218\uac00 \ud3ec\ud568\ub429\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub9e4\uac1c\ubcc0\uc218\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc791\uc740 \ubd84\uc790\uc758 \uc6a9\ud574 \uc790\uc720 \uc5d0\ub108\uc9c0\uc5d0 \ub300\ud55c \uc2e4\ud5d8 \uac12\uc744 \ub9de\ucd94\uc5b4 \uacb0\uc815\ub429\ub2c8\ub2e4.<br \/>\n\uadf9\uc131 \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \uace0\ub824\ud558\ub294 \ub370 \uac00\uc7a5 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ubaa8\ub378\uc740 \uc6a9\ub9e4\uac00 \ucc28\uc9c0\ud558\ub294 \uc601\uc5ed\uc744 \ud2b9\uc815 \uc720\uc804\uc728(\ubb3c\uc758 \uacbd\uc6b0 78.4)\uc744 \uac00\uc9c4 \uc5f0\uc18d \ub9e4\uc9c8\ub85c \uac04\uc8fc\ud558\uace0 \uc6a9\uc9c8 \uc601\uc5ed\uc740 \ub0ae\uc740 \uc720\uc804\uc728(\uc77c\ubc18\uc801\uc73c\ub85c 2-8 \uac12) \ub610\ub294 \uc9c4\uacf5(\uc720\uc804\uc728 1)\uc744 \uac00\uc9c4 \ub9e4\uc9c8\uc774 \ucc28\uc9c0\ud558\ub294 \uac83\uc73c\ub85c \uac04\uc8fc\ud569\ub2c8\ub2e4(\uadf8\ub9bc 3A). \uc5f0\uc18d \ub9e4\uc9c8\uc740 \uc6a9\uc9c8 \uc601\uc5ed\uc758 \uc804\ud558 \ubd84\ud3ec\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc815\uc804\uae30\uc7a5\uc5d0 \uc758\ud574 \ubd84\uadf9\ub418\uace0, \uadf8 \uacb0\uacfc \ubd84\uadf9\ub41c \uc804\ud558 \ubd84\ud3ec\ub294 \uc6a9\uc9c8 \uc601\uc5ed\uc5d0\uc11c \uc6a9\uc9c8 \uc804\ud558\uc5d0 \uc791\uc6a9\ud558\ub294 \uc815\uc804\uae30\uc7a5\uc744 \ucc28\ub840\ub85c \uc0dd\uc131\ud569\ub2c8\ub2e4. \ubd84\uadf9\ub41c \uc804\ud558\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc804\uae30\uc7a5\uc744 \ubc18\uc751\uc7a5\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc815\uc804\uae30 \uc5f0\uc18d \ub9e4\uccb4 \ubaa8\ub378\uc740 \ubc18\uc751\uc7a5 \ubaa8\ub378\uc774\ub77c\uace0\ub3c4 \ud569\ub2c8\ub2e4. \uc6a9\ub9e4 \uc601\uc5ed\uc5d0 \uc790\uc720 \uc774\uc628\uc774 \uc5c6\ub294 \uc5f0\uc18d \ub9e4\uc9c8 \ubaa8\ub378\uc5d0\uc11c \uacf5\uac04 \uc815\uc804\uae30 \uc804\uc704\uc640 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec \uc0ac\uc774\uc758 \uad00\uacc4\ub294 \ud478\uc544\uc1a1 \ubc29\uc815\uc2dd\uc744 \ub9cc\uc871\ud569\ub2c8\ub2e4. \uc790\uc720 \uc774\uc628\uc774 \ud3ec\ud568\ub41c \uc6a9\uc561 \ud658\uacbd\uc758 \uacbd\uc6b0, \uc774\uc628\uc758 \uacf5\uac04 \ubd84\ud3ec\ub294 \uacf5\uac04 \uc815\uc804\uae30 \uc804\uc704\uc758 \uc601\ud5a5\uc744 \ubc1b\uc2b5\ub2c8\ub2e4. \uc774 \uc694\uc18c\ub97c \uace0\ub824\ud558\uba74 \uacf5\uac04 \uc815\uc804\uc704\uc640 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec\uc758 \uad00\uacc4\ub294 \ud478\uc544\uc1a1-\ubcfc\uce20\ub9cc \ubc29\uc815\uc2dd(PB \ubc29\uc815\uc2dd)\uc744 \ub9cc\uc871\ud558\uba70, PB \ubc29\uc815\uc2dd\uc740 3\ucc28\uc6d0 \uacf5\uac04\uc5d0\uc11c \uc815\uc804\uc704 \ubd84\ud3ec\uc640 \uc804\ud558 \ubc0f \uc720\uc804\uccb4\uc758 \ubd84\ud3ec \uc0ac\uc774\uc758 \uad00\uacc4\uc5d0 \uad00\ud55c \ud3b8\ubbf8\ubd84 \ubc29\uc815\uc2dd\uc73c\ub85c \uc218\uce58\uc801\uc73c\ub85c \ud480 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud6a8\uc18c\uc640 \uac19\uc740 \uac70\ub300 \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc758 PB \ubc29\uc815\uc2dd\uc744 \ud478\ub294 \uac00\uc7a5 \uc77c\ubc18\uc801\uc778 \uc218\uce58\uc801 \ubc29\ubc95\uc740 \uc720\ud55c \ucc28\ubd84\ubc95(FD)\uc774\uba70, \uc774\ub97c \ud1b5\uce6d\ud558\uc5ec FDPB \ubaa8\ub378\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4(\uadf8\ub9bc 3B). <sup>[14].<\/sup> FDPB\ub97c \uc0ac\uc6a9\ud558\uba74 \uc6a9\uc9c8\uc758 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec\ub97c \uae30\ubc18\uc73c\ub85c 3\ucc28\uc6d0\uc5d0\uc11c \uc815\uc804\uae30 \uc804\uc704\ub97c \uacc4\uc0b0\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 \uc815\uc804\uae30 \uc790\uc720 \uc5d0\ub108\uc9c0\uc640 \uac19\uc740 \ub2e4\ub978 \ud2b9\uc131\ub3c4 \uacc4\uc0b0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc800\ubd84\uc790 \uc2dc\uc2a4\ud15c\uc5d0 \ub300\ud55c QM \uacc4\uc0b0\uc5d0\uc11c \ubc18\uc751\uc7a5\uc740 \uc885\uc885 \ubd84\uc790 \ud45c\uba74\uc758 \ud45c\uba74 \uc804\ud558 \ubd84\ud3ec\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc804\uae30\uc7a5\uc73c\ub85c \ub3d9\ub4f1\ud558\uac8c \ub300\uccb4\ub418\uba70, \ud574\ub2f9 \ubaa8\ub378\uc744 \ud3b8\uadf9\uc131 \uc5f0\uc18d \ub9e4\uccb4(PCM) \ubaa8\ub378\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4.<br \/>\n\uadf9\uc131 \uc6a9\ub9e4 \ud6a8\uacfc\ub97c \uc124\uba85\ud558\uae30 \uc704\ud574 \uac00\uc7a5 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ubaa8\ub378\uc740 \uc6a9\ub9e4\uac00 \ucc28\uc9c0\ud558\ub294 \uc601\uc5ed\uc744 \ud2b9\uc815 \uc720\uc804\uc728(\ubb3c\uc758 \uacbd\uc6b0 78.4)\uc744 \uac00\uc9c4 \uc5f0\uc18d \ub9e4\uc9c8\ub85c \ucde8\uae09\ud558\ub294 \ubc18\uba74 \uc6a9\uc9c8 \uc601\uc5ed\uc740 \ub0ae\uc740 \uc720\uc804\uc728(\uc77c\ubc18\uc801\uc73c\ub85c 2-8 \uac12) \ub610\ub294 \uc9c4\uacf5(\uc720\uc804\uc728 1)\uc744 \uac00\uc9c4 \ub9e4\uc9c8\uc774 \ucc28\uc9c0\ud558\ub294 \uac83\ucc98\ub7fc \ucde8\uae09\ud569\ub2c8\ub2e4(\uadf8\ub9bc 3A). \uc5f0\uc18d \ub9e4\uc9c8\uc740 \uc6a9\uc9c8 \uc601\uc5ed\uc758 \uc804\ud558 \ubd84\ud3ec\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc815\uc804\uae30\uc7a5\uc5d0 \uc758\ud574 \ubd84\uadf9\ub418\uace0, \uadf8 \uacb0\uacfc \ubd84\uadf9\ub41c \uc804\ud558 \ubd84\ud3ec\ub294 \ub2e4\uc2dc \uc6a9\uc9c8 \uc601\uc5ed\uc5d0\uc11c \uc6a9\uc9c8 \uc804\ud558\uc5d0 \uc791\uc6a9\ud558\ub294 \uc815\uc804\uae30\uc7a5\uc744 \uc0dd\uc131\ud569\ub2c8\ub2e4. \ubd84\uadf9\ub41c \uc804\ud558\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc804\uae30\uc7a5\uc744 \ubc18\uc751\uc7a5\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc815\uc804\uae30 \uc5f0\uc18d \ub9e4\uccb4 \ubaa8\ub378\uc740 \ubc18\uc751\uc7a5 \ubaa8\ub378\uc774\ub77c\uace0\ub3c4 \ud569\ub2c8\ub2e4. \uc6a9\ub9e4 \uc601\uc5ed\uc5d0 \uc790\uc720 \uc774\uc628\uc774 \uc5c6\ub294 \uc5f0\uc18d \ub9e4\uc9c8 \ubaa8\ub378\uc5d0\uc11c \uacf5\uac04 \uc815\uc804\uae30 \uc804\uc704\uc640 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec \uc0ac\uc774\uc758 \uad00\uacc4\ub294 \ud478\uc544\uc1a1 \ubc29\uc815\uc2dd\uc744 \ub9cc\uc871\ud569\ub2c8\ub2e4. \uc790\uc720 \uc774\uc628\uc774 \ud3ec\ud568\ub41c \uc6a9\uc561 \ud658\uacbd\uc758 \uacbd\uc6b0, \uc774\uc628\uc758 \uacf5\uac04 \ubd84\ud3ec\ub294 \uacf5\uac04 \uc815\uc804\uae30 \uc804\uc704\uc758 \uc601\ud5a5\uc744 \ubc1b\uc2b5\ub2c8\ub2e4. \uc774 \uc694\uc18c\ub97c \uace0\ub824\ud558\uba74 \uacf5\uac04 \uc815\uc804\uc704\uc640 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec\uc758 \uad00\uacc4\ub294 \ud478\uc544\uc1a1-\ubcfc\uce20\ub9cc \ubc29\uc815\uc2dd(PB \ubc29\uc815\uc2dd)\uc744 \ub9cc\uc871\ud558\uba70, PB \ubc29\uc815\uc2dd\uc740 3\ucc28\uc6d0 \uacf5\uac04\uc5d0\uc11c \uc815\uc804\uc704 \ubd84\ud3ec\uc640 \uc804\ud558 \ubc0f \uc720\uc804\uccb4\uc758 \ubd84\ud3ec \uc0ac\uc774\uc758 \uad00\uacc4\uc5d0 \uad00\ud55c \ud3b8\ubbf8\ubd84 \ubc29\uc815\uc2dd\uc73c\ub85c \uc218\uce58\uc801\uc73c\ub85c \ud480 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ud6a8\uc18c\uc640 \uac19\uc740 \uac70\ub300 \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc758 PB \ubc29\uc815\uc2dd\uc744 \ud478\ub294 \uac00\uc7a5 \uc77c\ubc18\uc801\uc778 \uc218\uce58\uc801 \ubc29\ubc95\uc740 \uc720\ud55c \ucc28\ubd84\ubc95(FD)\uc774\uba70, \uc774\ub97c \ud1b5\uce6d\ud558\uc5ec FDPB \ubaa8\ub378\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4(\uadf8\ub9bc 3B). <sup>[14].<\/sup> FDPB\ub97c \uc0ac\uc6a9\ud558\uba74 \uc6a9\uc9c8\uc758 \uacf5\uac04 \uc804\ud558 \ubd84\ud3ec\ub97c \uae30\ubc18\uc73c\ub85c 3\ucc28\uc6d0\uc5d0\uc11c \uc815\uc804\uae30 \uc804\uc704\ub97c \uacc4\uc0b0\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 \uc815\uc804\uae30 \uc790\uc720 \uc5d0\ub108\uc9c0\uc640 \uac19\uc740 \ub2e4\ub978 \ud2b9\uc131\ub3c4 \uacc4\uc0b0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc18c\ubd84\uc790 \uc2dc\uc2a4\ud15c\uc758 QM \uacc4\uc0b0\uc5d0\uc11c \ubc18\uc751\uc7a5\uc740 \uc885\uc885 \ubd84\uc790 \ud45c\uba74\uc758 \ud45c\uba74 \uc804\ud558 \ubd84\ud3ec\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c \uc804\uae30\uc7a5\uc73c\ub85c \ub4f1\uac00\uc801\uc73c\ub85c \ub300\uccb4\ub418\uba70, \ud574\ub2f9 \ubaa8\ub378\uc744 \ud3b8\uadf9\uc131 \uc5f0\uc18d \ub9e4\uccb4(PCM) \ubaa8\ub378\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4.<\/p>\n<p>\uadf8\ub9bc. <strong>3 <\/strong> \uc815\uc804\uae30 \uc5f0\uc18d\uccb4 \ubaa8\ub378 <strong>(A)<\/strong> \ubc0f \uc720\ud55c \ucc28\ubd84 \ud478\uc544\uc1a1-\ubcfc\uce20\ub9cc <strong>(FDPB) <\/strong> \uba54\uc11c\ub4dc <strong>(B)<\/strong><br \/>\n\uadf8\ub9bc 3 \uc815\uc804\uae30 \uc5f0\uc18d\uccb4 \ubaa8\ub378(A)\uacfc \uc720\ud55c\ucc28\ubd84 \ud478\uc544\uc1a1-\ubcfc\uce20\ub9cc(FDPB) \ubc29\ubc95(B).<\/p>\n<p>3.2<\/p>\n<p>\ubc29\ubc95 \uc801\uc6a9<\/p>\n<p>\uc5f0\uc18d\uccb4 \ubaa8\ub378\uc758 \uc911\uc694\ud55c \uc751\uc6a9 \ubd84\uc57c \uc911 \ud558\ub098\ub294 \ud6a8\uc18c \ubd84\uc790\uc5d0\uc11c \ud558\uc804\ub41c \uc544\ubbf8\ub178\uc0b0 \uce21\uc1c4\uae30\uc758 \uc591\uc131\uc790\ud654 \uc0c1\ud0dc\ub97c \uc5f0\uad6c\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc18c\ud504\ud2b8\uc6e8\uc5b4 PROPKA\ub294 PB \ubc29\uc815\uc2dd\uc744 \ud480\uc5b4 \ub2e4\uc591\ud55c \uc591\uc131\uc790 \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uc815\uc804\uae30\uc801 \uc790\uc720 \uc5d0\ub108\uc9c0\ub97c \uacc4\uc0b0\ud558\uc5ec \uac01 \ud574\ub9ac \uac00\ub2a5\ud55c \uadf8\ub8f9\uc758 pKa\ub97c \uc608\uce21\ud569\ub2c8\ub2e4. <sup>[50].<\/sup> \ud6a8\uc18c \ubd84\uc790\uc758 \ud45c\uba74 \uc815\uc804\uae30 \uc804\uc704 \ubd84\ud3ec\ub294 \ud6a8\uc18c\uc758 \uae30\uc9c8 \uc120\ud0dd\uc131\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc911\uc694\ud55c \uc694\uc18c\uc785\ub2c8\ub2e4. \ud6a8\uc18c \ubd84\uc790\uc758 \uacf5\uac04 \uad6c\uc870\uc640 \uc591\uc131\uc790 \uc0c1\ud0dc\uac00 \uc8fc\uc5b4\uc9c0\uba74 \ud6a8\uc18c \ubd84\uc790\uc758 \ud45c\uba74 \uc815\uc804\uae30 \uc804\uc704 \ubd84\ud3ec\ub294 FDPB \ubc29\ubc95\uc73c\ub85c \uacc4\uc0b0\ud560 \uc218 \uc788\uc73c\uba70, \uc544\ubbf8\ub178\uc0b0 \uc794\uae30\uc758 \ub3cc\uc5f0\ubcc0\uc774 \ub610\ub294 \ud658\uacbd pH\uc758 \ubcc0\ud654, \uc774\uc628 \ub18d\ub3c4 \ubcc0\ud654 \ub4f1\uc774 \ud45c\uba74 \uc815\uc804\uc704\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\ub3c4 \uc608\uce21\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[14].<\/sup><br \/>\nQM \ud074\ub7ec\uc2a4\ud130 \ubaa8\ub378\ub85c \ud6a8\uc18c \ucd09\ub9e4\uc758 \ud654\ud559\uc801 \ub2e8\uacc4\ub97c \uc5f0\uad6c\ud560 \ub54c, \ubc18\uc751 \uc601\uc5ed\uc5d0 \ub300\ud55c \ud658\uacbd\uc758 \uc815\uc804\uae30\uc801 \uc601\ud5a5\uc744 \uc2dc\ubbac\ub808\uc774\uc158\ud558\uae30 \uc704\ud574 PCM \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud574\uc57c \ud558\ub294 \uacbd\uc6b0\uac00 \uc885\uc885 \uc788\uc2b5\ub2c8\ub2e4. \ubc18\uc751 \uacfc\uc815\uc5d0 \uc804\ud558 \ubd84\ud3ec\uc5d0 \uc0c1\ub2f9\ud55c \ubcc0\ud654\uac00 \uc788\ub294 \uacbd\uc6b0, \uc5f0\uc18d \ub9e4\uccb4\ub97c \uc0ac\uc6a9\ud558\uc9c0 \uc54a\uc740 \uc9c4\uacf5 QM \uacc4\uc0b0 \uacb0\uacfc\ub294 \ud569\ub9ac\uc801\uc774\uc9c0 \uc54a\uc73c\uba70 \uc798\ubabb\ub41c \uc815\uc131\uc801 \uacb0\ub860\uc744 \ub3c4\ucd9c\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. QM\/MM \ubaa8\ub378\uc5d0\uc11c \ubc18\uc751 \uc911\uc2ec\uc740 \uc77c\ubc18\uc801\uc73c\ub85c MM \ubc29\uc2dd\uc73c\ub85c \ucc98\ub9ac\ub418\ub294 \uc6a9\ud574\uc131 \ubd84\uc790\ub85c \ub458\ub7ec\uc2f8\uc5ec \uc788\uc73c\uba70, \uc77c\ubc18\uc801\uc73c\ub85c \uc5f0\uc18d \ub9e4\uccb4 \ubc18\uc751\uc7a5\uc744 \uace0\ub824\ud560 \ud544\uc694\uac00 \uc5c6\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ubc18\uc751 \uc804\ud6c4\uc5d0 \uc2dc\uc2a4\ud15c\uc758 \uc21c\uc804\ud558\uac00 \ubcc0\ud654\ud558\ub294 \uacbd\uc6b0(\uc608: \uc0b0\ud654 \ud658\uc6d0 \uc804\uc704 \uacc4\uc0b0), \uc2dc\uc2a4\ud15c \uacbd\uacc4 \uc678\ubd80\uc758 \uc6a9\uc561 \ud658\uacbd\uc774 \ubc18\uc751\uc758 \uc790\uc720 \uc5d0\ub108\uc9c0\uc5d0 \uae30\uc5ec\ud558\ub294 \ubc14\ub97c \uace0\ub824\ud574\uc57c \ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc73c\uba70, \uc774 \uacbd\uc6b0 \uc5f0\uc18d\uccb4 \ub9e4\uccb4 \ubaa8\ub378\uc744 \uc0ac\uc6a9\ud558\uc5ec QM\/MM \uacb0\uacfc\ub97c \ubcf4\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\ud6a8\uc728\uc131\uacfc \uc815\ud655\uc131\uc758 \uade0\ud615\uc744 \ub9de\ucd94\ub294 \ubc29\ubc95\uc73c\ub85c\uc11c MM\/PBSA\ub294 \ub2e8\ubc31\uc9c8-\ub2e8\ubc31\uc9c8 \ubc0f \ub2e8\ubc31\uc9c8-\uc18c\ubd84\uc790 \ubcf5\ud569\uccb4\uc758 \uce5c\ud654\uc131\uc744 \ubd84\uc11d\ud558\ub294 \ub370 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[49].<\/sup> \uc624\ucc28 \uc81c\uac70\ub97c \uc704\ud574\uc11c\ub294 \ubcf5\ud569\uccb4\uc758 \uba85\uc2dc\uc801 \uc6a9\ub9e4 \ubd84\uc790 \uc5ed\ud559 \uc2dc\ubbac\ub808\uc774\uc158\uc744 \uc218\ud589\ud558\uc5ec \ubcf5\ud569\uccb4\uc758 \ud615\ud0dc\ub97c \uc5bb\uace0, \uac01 \ubcf5\ud569\uccb4 \ud615\ud0dc\uc5d0 \ub300\ud574 \ubcf5\ud569\uccb4 \uc804\uccb4\uc640 \ubcf5\ud569\uccb4\ub97c \uad6c\uc131\ud558\ub294 \uac01 \ubaa8\ub178\uba38\uc758 MM\/PBSA \uc5d0\ub108\uc9c0\ub97c \uac01\uac01 \uacc4\uc0b0\ud558\uace0, \uc804\uccb4 \ud615\ud0dc\uc5d0 \ub300\ud55c \uc804\uccb4 MM\/PBSA \uc5d0\ub108\uc9c0\uc640 \ubaa8\ub178\uba38\uc758 \uc5d0\ub108\uc9c0 \ucc28\uc774\uc758 \ud3c9\uade0\uc744 \uc0ac\uc6a9\ud558\uc5ec \uacb0\ud569\uc758 \uc790\uc720 \uc5d0\ub108\uc9c0\ub97c \uadfc\uc0ac\ud654\ud558\ub294 \uac83\uc774 \uc77c\ubc18\uc801\uc785\ub2c8\ub2e4. \uc774 \ubc29\ubc95\uc740 \uae30\uc9c8 \uce5c\ud654\ub3c4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ud56b\uc2a4\ud31f \uc794\uae30\ub97c \ubd84\uc11d\ud558\ub294 \ub370 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc73c\uba70 \ub3cc\uc5f0\ubcc0\uc774\uc758 \uae30\uc9c8 \uc120\ud0dd\uc131 \ubcc0\ud654\ub97c \uc608\uce21\ud558\ub294 \ub370\uc5d0\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>4<\/p>\n<p>\uae30\ud0c0 \ubc29\ubc95<\/p>\n<p>4.1<\/p>\n<p>\ubd84\uc790 \ub3c4\ud0b9<\/p>\n<p>\ub3c4\ud0b9\uc740 \ub2e8\ub7c9\uccb4\uc758 \uad6c\uc870\ub97c \uae30\ubc18\uc73c\ub85c \ubcf5\ud569\uccb4\uc758 \uad6c\uc870(\ubc0f \uce5c\ud654\ub825)\ub97c \uc608\uce21\ud558\ub294 \uacc4\uc0b0 \ud504\ub85c\uc138\uc2a4\ub97c \ub9d0\ud569\ub2c8\ub2e4. \uc800\ubd84\uc790 \ub2e8\ubc31\uc9c8 \ub3c4\ud0b9\uc740 \uad6c\uc870 \uae30\ubc18 \uc57d\ubb3c \uac00\uc0c1 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \uc704\ud55c \ud575\uc2ec \ub3c4\uad6c\ub85c, \uc774\ub97c \uc704\ud574 \uc5ec\ub7ec \uc54c\uace0\ub9ac\uc998\uc774 \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. <sup>[13].<\/sup> \uc774\ub7ec\ud55c \uc54c\uace0\ub9ac\uc998\uacfc \ubaa8\ub378\uc740 \uae30\uc9c8-\ud6a8\uc18c \ubcf5\ud569\uccb4\uc758 \ub3c4\ud0b9\uc5d0\ub3c4 \uc801\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uac00\uc0c1 \uc57d\ubb3c \uc2a4\ud06c\ub9ac\ub2dd\uc740 \uc218\ub9ce\uc740 \uc11c\ub85c \ub2e4\ub978 \uc800\ubd84\uc790\ub97c \uace0\ub824\ud574\uc57c \ud558\uba70, \uacc4\uc0b0 \ud6a8\uc728\uc131\uc758 \uc774\uc720\ub85c \ubd84\uc790 \ub3c4\ud0b9 \uacc4\uc0b0\uc5d0\uc11c \uc218\uc6a9\uccb4(\ub610\ub294 \uce21\uc1c4)\uc758 \uad6c\uc870\uc801 \ubcc0\ud654\ub294 \uace0\ub824\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc2b5\ub2c8\ub2e4. \uac00\uc0c1 \uc2a4\ud06c\ub9ac\ub2dd\uacfc \ub2ec\ub9ac \uae30\uc9c8-\ud6a8\uc18c \ub3c4\ud0b9 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud558\ub098 \ub610\ub294 \uc5ec\ub7ec \uac1c\uc758 \ub2e4\ub978 \uae30\uc9c8\ub9cc \uace0\ub824\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc73c\uba70, \uc6d0\uce59\uc801\uc73c\ub85c \ud6a8\uc18c\uc758 \uad6c\uc870\uc801 \ubcc0\ud654\ub97c \ub354 \uc644\ubcbd\ud558\uac8c \uace0\ub824\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \ub2ec\uc131\ud558\ub294 \uac00\uc7a5 \uac04\ub2e8\ud55c \ubc29\ubc95\uc740 \uae30\uc9c8\uc5d0 \uac1c\ubcc4\uc801\uc73c\ub85c \ub3c4\ud0b9\ud558\ub294 MD\uc640 \uac19\uc740 \ucee8\ud3ec\uba40 \uc0d8\ud50c\ub9c1 \ubc29\ubc95\uc744 \ud1b5\ud574 \ub2e4\uc591\ud55c \ud6a8\uc18c \uad6c\uc870\ub97c \uc5bb\ub294 \uac83\uc785\ub2c8\ub2e4. \uae30\uc9c8-\ud6a8\uc18c \ub3c4\ud0b9\uc5d0\uc11c\ub294 \uae30\uc9c8\uacfc \ucd09\ub9e4 \uc791\uc6a9\uae30\uc758 \uc0c1\ub300\uc801\uc778 \uacf5\uac04 \ubc30\uc5f4\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub3c4\ud0b9 \uacb0\uacfc\ub97c \uc120\ubcc4\/\ud3c9\uac00\ud558\ub294 \uac83\ub3c4 \uc885\uc885 \uac00\ub2a5\ud569\ub2c8\ub2e4.<\/p>\n<p>4.2<\/p>\n<p>\uae30\ud558\ud559\uc801 \uad6c\uc870\ub97c \uae30\ubc18\uc73c\ub85c \ud55c \uc800\ubd84\uc790 \uae30\uacf5 \uc608\uce21<\/p>\n<p>\uc218\ub9ce\uc740 \uc2e4\ud5d8 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ud65c\uc131 \uc911\uc2ec\uc5d0\uc11c \uba40\ub9ac \ub5a8\uc5b4\uc9c4 \uc77c\ubd80 \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud6a8\uc18c\uc758 \ucd09\ub9e4 \uc131\ub2a5\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubd80\uc704 \uc911 \uc77c\ubd80\ub294 \uae30\uc9c8 \uacb0\ud569\/\uc0dd\uc131\ubb3c \ubc29\ucd9c \uae30\uacf5\uc744 \ubcc0\uacbd\ud558\uc5ec \uc791\uc6a9\ud560 \uc218 \uc788\uc73c\uba70 \uae30\uacf5 \ud06c\uae30, \uae30\uacf5 \uc8fc\ubcc0 \uc794\ub958\ubb3c\uc758 \ubb3c\ub9ac\ud654\ud559\uc801 \ud2b9\uc131 \ub4f1\uc774 \uae30\uc9c8\/\uc0dd\uc131\ubb3c \ud1b5\uacfc\uc728\uc744 \ubcc0\ud654\uc2dc\ud0a4\uace0 \uae30\uc9c8 \uc120\ud0dd\uc131\uc5d0 \uc601\ud5a5\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uae30\uacf5 \uc608\uce21 \ubc29\ubc95\uc740 \uad00\ub828 \ud56b \uc794\ub958\ubb3c\uc744 \ucc3e\uace0 \uc9c0\uc2dc\ub41c \uc9c4\ud654 \ub77c\uc774\ube0c\ub7ec\ub9ac \uc124\uacc4\uc758 \uae30\ucd08\ub97c \uc81c\uacf5\ud558\ub294 \ub370 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub2e8\ubc31\uc9c8 \ud45c\uba74 \ud53c\ud2b8, \ub0b4\ubd80 \uacf5\ub3d9, \uc11c\ub85c \ub2e4\ub978 \uc601\uc5ed\uc744 \uc5f0\uacb0\ud558\ub294 \uae30\uacf5 \ub4f1\uc744 \uc608\uce21\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \uae30\ud558\ud559\uc801 \uad6c\uc870 \uae30\ubc18 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <sup>[51-53].<\/sup> \uc774\ub7ec\ud55c \ubc29\ubc95\uc740 \uc815\uc801 \uacf5\uac04 \uad6c\uc870\ub97c \uc785\ub825\uc73c\ub85c \uc0ac\uc6a9\ud558\uba70, \ub300\ubd80\ubd84 \uae30\ud558\ud559\uc801 \ubc0f \uadf8\ub798\ud504 \uc774\ub860\uc801 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub192\uc740 \uacc4\uc0b0 \ud6a8\uc728\ub85c \uc608\uce21\uc744 \uc2e4\ud604\ud569\ub2c8\ub2e4.<\/p>\n<p>4.3<\/p>\n<p>\uc561\ud2f0\ube0c \uc13c\ud130 \ube44\uad50 \ubc29\ubc95<\/p>\n<p>\ud604\uc7ac \ub2e8\ubc31\uc9c8 3D \uad6c\uc870 \ub370\uc774\ud130\ubca0\uc774\uc2a4(PDB)\uc5d0\ub294 \ub2e4\uc591\ud55c \uad6c\uc870 \uc720\ud615\uacfc \uacc4\uc5f4\uc744 \uac00\uc9c4 \ud6a8\uc18c\uc758 3D \uad6c\uc870 \ub370\uc774\ud130\uac00 \ub300\ub7c9\uc73c\ub85c \ucd95\uc801\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc11c\ub85c \ub2e4\ub978 \ud6a8\uc18c\ub97c \ube44\uad50\ud558\uba74 \uc804\uccb4 \uad6c\uc870 \uc11c\uc5f4\uc774 \uc720\uc0ac\ud558\uc9c0 \uc54a\ub354\ub77c\ub3c4 \uc77c\ubd80 \ud6a8\uc18c\ub294 \ud65c\uc131 \uc911\uc2ec\uc774 \ub9e4\uc6b0 \uc720\uc0ac\ud558\ub2e4\ub294 \uac83\uc744 \uc54c \uc218 \uc788\uc2b5\ub2c8\ub2e4(\ub300\ud45c\uc801\uc778 \uc608\ub85c \uc138\ub9b0 \ud504\ub85c\ud14c\uc544\uc81c\uac00 \uacf5\uc720\ud558\ub294 \ucd09\ub9e4 \uc0bc\uc911 \ud65c\uc131 \uc911\uc2ec\uc774 \uc788\uc2b5\ub2c8\ub2e4). \ud65c\uc131 \uc911\uc2ec \uad6c\uc870 \ube44\uad50 \ubc29\ubc95 <sup>[54-55] \uce94<\/sup> \ub97c \uc0ac\uc6a9\ud558\uc5ec \ud604\uc7ac \ud6a8\uc18c\uc758 \ud65c\uc131 \uc911\uc2ec\uacfc \uc720\uc0ac\ud55c \ub2e4\ub978 \ud6a8\uc18c\uc758 \ud65c\uc131 \uc911\uc2ec\uc744 \uc790\ub3d9\uc73c\ub85c \uac80\uc0c9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. 3\ucc28\uc6d0 \uacf5\uac04\uc5d0\uc11c \uc5ec\ub7ec \uac1c\uc758 \uc720\uc0ac\ud55c \ud65c\uc131 \uc911\uc2ec\uc744 \ud568\uaed8 \uc313\uace0 \uc11c\ub85c \ub2e4\ub978 \ud65c\uc131 \uc911\uc2ec \uac04\uc758 \uc720\uc0ac\uc810\uacfc \ucc28\uc774\uc810\uc744 \ubd84\uc11d\ud558\uba74 \ub3cc\uc5f0\ubcc0\uc774 \ubd80\uc704 \uc120\ud0dd\uc5d0 \uc720\uc6a9\ud55c \uc815\ubcf4\ub97c \uc5bb\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>5<\/p>\n<p>\uc694\uc57d<\/p>\n<p>\uc124\uba85\uc758 \uba85\ud655\uc131\uc744 \uc704\ud574 \uc704\uc758 \ubc29\ubc95\uc744 \ubd84\ub958\ud558\uc5ec \uc18c\uac1c\ud569\ub2c8\ub2e4. \uc2e4\uc81c\ub85c\ub294 \uc11c\ub85c \ub2e4\ub978 \uc720\ud615\uc758 \ubc29\ubc95\uc774 \uc0c1\ud638 \ubc30\ud0c0\uc801\uc774\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uad00\uc2ec \uc788\ub294 \uc9c8\ubb38\uc5d0 \ub354 \uc798 \ub2f5\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \uac00\uc9c0 \ubc29\ubc95\uc73c\ub85c \uc870\ud569\ud558\uc5ec \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud6a8\uc18c-\uae30\uc9c8 \ubcf5\ud569\uccb4 \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c \ubd84\uc790 \ub3c4\ud0b9\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc2dc\ubbac\ub808\uc774\uc158\uc758 \ucd08\uae30 \ud615\ud0dc\ub97c \uc5bb\uc744 \uc218 \uc788\uace0, MD \uc2dc\ubbac\ub808\uc774\uc158\uc5d0\uc11c \uc5bb\uc740 \ud615\ud0dc \uc9d1\ud569\uc744 \uae30\uacf5 \uc608\uce21 \ubd84\uc11d, \ubd84\uc790 \ub3c4\ud0b9, QM\/MM \uc2dc\ubbac\ub808\uc774\uc158 \ub4f1\uc5d0 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.QM \ub610\ub294 QM\/MM \ubaa8\ub378\uc5d0\uc11c \uc5bb\uc740 \uc804\uc774 \uc0c1\ud0dc\ub97c \uc0c8\uae34 MM \ubaa8\ub378\uc744 \uad6c\ucd95\ud558\uc5ec \uc7a5\uc2dc\uac04 \uace0\uc804\uc801\uc778 MD \uc2dc\ubbac\ub808\uc774\uc158\uc5d0 \uc0ac\uc6a9\ud558\uc5ec \ud654\ud559 \uacf5\uc815\uc5d0 \ub300\ud55c \ud615\ud0dc \uc0c1\uc2b9 \ubc0f \ud558\uac15\uc758 \uc601\ud5a5\uc744 \ubd84\uc11d\ud558\uac70\ub098 \ub9ce\uc740 \uc218\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc2dc\ubbac\ub808\uc774\uc158\ud558\uc5ec MD \uc2dc\ubbac\ub808\uc774\uc158\uc744 \uae30\ubc18\uc73c\ub85c \ub3cc\uc5f0\ubcc0\uc774\uc758 \uac00\uc0c1 \uc2a4\ud06c\ub9ac\ub2dd\uc744 \uc2e4\ud604\ud560 \uc218 \uc788\uc73c\uba70, \uc774\ubbf8 \uc5b8\uae09\ud55c MM\/PBSA \ubc29\uc2dd\uc740 MD\uc640 \uc5f0\uc18d \ub9e4\uccb4 \ubaa8\ub378\ub9c1\uc758 \uc870\ud569 \ub4f1 \ub2e4\uc591\ud55c \uc6a9\ub3c4\ub85c \ud65c\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n\uacc4\uc0b0 \ud654\ud559 \ubc29\ubc95\uc73c\ub85c \ub2e8\ubc31\uc9c8\uacfc \uac19\uc740 \uc0dd\uccb4 \ubd84\uc790 \uc2dc\uc2a4\ud15c\uc744 \uc5f0\uad6c\ud558\ub294 \uac83\uc740 40\ub144 \uc774\uc0c1\uc758 \uc5ed\uc0ac\ub97c \uac00\uc9c0\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubc29\ubc95\uc740 \uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0\uc11c \uc810\uc810 \ub354 \ub110\ub9ac \uc0ac\uc6a9\ub418\uba70 \uc9c0\uc18d\uc801\uc73c\ub85c \ubc1c\uc804\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uc911\uad6d\uc758 \uacc4\uc0b0 \ud654\ud559 \ubc0f \uc0b0\uc5c5 \ud6a8\uc18c \uacf5\ud559 \uc5f0\uad6c\ud300\uc774 \ud655\ub300\ub418\uace0 \uc788\uc73c\uba70 \uc5f0\uad6c \uc5ed\ub7c9\uc774 \ube60\ub974\uac8c \ud5a5\uc0c1\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud6a8\uc18c \uacf5\ud559\uc5d0\uc11c \uacc4\uc0b0 \ud654\ud559\uc758 \uc751\uc6a9\uc740 \uc774 \ub450 \ud559\ubb38\uc758 \uad50\ucc28 \uacb0\ud569\uc774 \uc810\uc810 \ub354 \uac00\uae4c\uc6cc\uc9d0\uc5d0 \ub530\ub77c \ub354 \ub113\uace0 \uae4a\uc5b4\uc9c8 \uac83\uc785\ub2c8\ub2e4. \ub2e8\ubc31\uc9c8 \uacf5\ud559, \uc720\ub3c4 \uc9c4\ud654 \ubc0f \uae30\ud0c0 \uae30\uc220\uc740 \uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\ucce4\uc2b5\ub2c8\ub2e4. \ud5a5\ud6c4 \uacc4\uc0b0 \ubc29\ubc95\uc758 \ubc1c\uc804, \ud2b9\ud788 \uc0c8\ub85c\uc6b4 \ud6a8\uc18c \uc124\uacc4 \ubc29\ubc95\uc758 \ud68d\uae30\uc801\uc778 \ubc1c\uc804\uc740 \ud569\uc131 \uc0dd\ubb3c\ud559 \uc2dc\ub300\uc758 \uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0 \uc0c8\ub85c\uc6b4 \uae30\uc220 \ud601\uc2e0\uc744 \uac00\uc838\uc62c \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4.<\/p>\n<p><!-- lc-commercial-start --><\/p>\n<h2>How buyers usually evaluate enzyme and food-processing ingredients<\/h2>\n<p>\ud6a8\uc18c \ubc0f \uc2dd\ud488 \uac00\uacf5 \ud504\ub85c\uc81d\ud2b8\uc5d0\uc11c\ub294 \uac00\uc7a5 \uc720\uc6a9\ud55c \uc758\uc0ac \uacb0\uc815 \ud504\ub808\uc784\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc751\uc6a9 \uc801\ud569\uc131\uacfc \uacf5\uc815 \uc548\uc815\uc131\uc785\ub2c8\ub2e4. \uc989, \uc5b4\ub5a4 \uc131\ubd84\uc774 \uc758\ub3c4\ub41c pH, \uc628\ub3c4, \uc2dc\uac04 \ubc0f \uae30\uc9c8 \uc870\uac74\uc5d0\uc11c downstream \ud488\uc9c8\uc774\ub098 \uaddc\uc81c \ubb38\uc81c\ub97c \uc57c\uae30\ud558\uc9c0 \uc54a\uace0 \uc131\ub2a5\uc744 \ubc1c\ud718\ud558\ub294\uc9c0\uc785\ub2c8\ub2e4.<\/p>\n<ul>\n<li><strong>\uba3c\uc800 \ucc98\ub9ac \ub300\uc0c1\uc744 \uc815\uc758\ud558\uc2ed\uc2dc\uc624:<\/strong> \ub9db, \uac00\uc218\ubd84\ud574, \uc9c8\uac10, \ubc1c\ud6a8, \uc138\ucc99 \ubc0f \uc0dd\ubb3c \uacf5\uc815 \uc751\uc6a9 \ubd84\uc57c\ub294 \uc885\uc885 \ub9e4\uc6b0 \ub2e4\ub978 \ud65c\uc131 \ud504\ub85c\ud30c\uc77c\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/li>\n<li><strong>\uc2e4\ud589 \uc911\uc778 \ucc3d \ud655\uc778<\/strong> pH, \uc628\ub3c4, \uccb4\ub958 \uc2dc\uac04, \uae30\uc9c8 \uc720\ud615\uc740 \uc885\uc885 \ud5e4\ub4dc\ub77c\uc778 \uc81c\ud488 \uc8fc\uc7a5\ubcf4\ub2e4 \ub354 \uc911\uc694\ud569\ub2c8\ub2e4.<\/li>\n<li><strong>\uc77c\uad00\uc131\uacfc \ub2e4\uc6b4\uc2a4\ud2b8\ub9bc \uc601\ud5a5 \uac80\ud1a0<\/strong> \ubcf5\uc6a9\ub7c9, \uac10\uac01\uc801 \uc601\ud5a5, \uc5ec\uacfc \ubc0f \uc800\uc7a5 \uc218\uba85 \ub3d9\uc791\uc740 \ubaa8\ub450 \ucd5c\uc885 \uc0c1\uc5c5\uc801 \uac00\uce58\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/li>\n<li><strong>\ud30c\uc77c\ub7ff \uac80\uc99d \uc0ac\uc6a9<\/strong> \uc18c\uaddc\ubaa8 \uc0dd\uc0b0 \ud14c\uc2a4\ud2b8\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ud65c\ub3d9, \ud6a8\uc728\uc131, \uacf5\uc815 \uc801\ud569\uc131\uc5d0\uc11c \uac00\uc7a5 \uc720\uc6a9\ud55c \ucc28\uc774\uc810\uc744 \ub4dc\ub7ec\ub0c5\ub2c8\ub2e4.<\/li>\n<\/ul>\n<h3>\ucd94\ucc9c \uc81c\ud488 \ucc38\uace0<\/h3>\n<ul>\n<li><strong><a href=\"https:\/\/longchangchemical.com\/ko\/product\/hema-monomer-cas-868-77-9\/\">CHLUMICRYL HEMA<\/a>:<\/strong> A well-known polar monomer reference in adhesion- and reactivity-driven systems.<\/li>\n<li><strong><a href=\"https:\/\/longchangchemical.com\/ko\/product\/lipase-cas-9001-62-1\/\">\ub871\uc790\uc784 \ub9ac\ud30c\uc544\uc81c<\/a>:<\/strong> \ub9ac\ud30c\uc544\uc81c \uad00\ub828 \uc2dd\ud488, \uc138\ucc99 \ub610\ub294 \ubc14\uc774\uc624\ud504\ub85c\uc138\uc2a4 \ub17c\uc758\ub97c \uc704\ud55c \uc9c1\uc811\uc801\uc778 \uc81c\ud488 \ucc38\uc870<\/li>\n<li><strong><a href=\"https:\/\/longchangchemical.com\/ko\/product\/beta-amylase-cas-9000-91-3\/\">\ub871\uc790\uc784 \ubca0\ud0c0-\uc544\ubc00\ub77c\uc544\uc81c<\/a>:<\/strong> \uc804\ubd84 \uc804\ud658 \ubc0f \uc2dd\ud488 \uac00\uacf5 \ud65c\ub3d9\uc744 \uac80\ud1a0\ud560 \ub54c \uc2e4\uc6a9\uc801\uc778 \ud6a8\uc18c \ucc38\uace0 \uc790\ub8cc.<\/li>\n<li><strong><a href=\"https:\/\/longchangchemical.com\/ko\/product\/compound-glucoamylase-cas-9032-08-0\/\">\ub871\uc790\uc784 \ubcf5\ud569 \uae00\ub8e8\ucf54\uc544\ubc00\ub77c\uc81c<\/a>:<\/strong> \ub2f9\ud654 \ub610\ub294 \uad00\ub828 \uacf5\uc815 \uc131\ub2a5\uc774 \uc911\uc694\ud560 \ub54c \uc720\uc6a9\ud55c \ud6a8\uc18c \ucc38\uace0 \uc790\ub8cc<\/li>\n<\/ul>\n<h3>\uad6c\ub9e4\uc790 \ubc0f \uc81c\ud615 \ub2f4\ub2f9\uc790\ub97c \uc704\ud55c FAQ<\/h3>\n<p><strong>\ud65c\ub3d9\uc131\uc774 \ub192\uc740 \ud6a8\uc18c\uac00 \ubc18\ub4dc\uc2dc \uc0c1\uc5c5\uc801\uc73c\ub85c \uac00\uc7a5 \uc88b\uc740 \uc120\ud0dd\uc774 \uc544\ub2cc \uc774\uc720\ub294 \ubb34\uc5c7\uc778\uac00\uc694?<\/strong><br \/>\ucd5c\uace0\uc758 \ud6a8\uc18c\ub294 \uc2e4\uc81c \uacf5\uc815 \uc870\uac74 \ud558\uc5d0\uc11c \uc548\uc815\uc801\uc73c\ub85c \uc791\uc6a9\ud558\uace0 \uc0c8\ub85c\uc6b4 \ubb38\uc81c\ub97c \uc77c\uc73c\ud0a4\uc9c0 \uc54a\uc73c\uba74\uc11c \uc6d0\ud558\ub294 \ub2e4\uc6b4\uc2a4\ud2b8\ub9bc \uacb0\uacfc\ub97c \uc81c\uacf5\ud558\ub294 \ud6a8\uc18c\uc774\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n<p><strong>\uc2dd\ud488 \ubc0f \uc0dd\uba85\uacf5\ud559 \uc6d0\ub8cc\ub294 \ub370\uc774\ud130 \uc2dc\ud2b8\ub9cc\uc73c\ub85c \uc120\ud0dd\ud574\uc57c \ud560\uae4c\uc694?<\/strong><br \/>\uc77c\ubc18\uc801\uc73c\ub85c \uc2e4\uc81c \uae30\ud310\uacfc \uacf5\uc815 \ucc3d\uc774 \uacb0\uacfc\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\ubbc0\ub85c \uba85\uc138 \uac80\ud1a0\ub97c \ud30c\uc77c\ub7ff \ub610\ub294 \uc560\ud50c\ub9ac\ucf00\uc774\uc158 \ud14c\uc2a4\ud2b8\uc640 \ud568\uaed8 \uc9c4\ud589\ud558\ub294 \uac83\uc774 \ub354 \uc548\uc804\ud569\ub2c8\ub2e4.<\/p>\n<p><!-- lc-commercial-end --><\/p>\n<h2><strong><b>\uc9c0\uae08 \ubb38\uc758\ud558\uc138\uc694!<\/b><\/strong><\/h2>\n<h4><strong><b>\uac00\uaca9\uc774 \ud544\uc694\ud55c \uacbd\uc6b0 \uc544\ub798 \uc591\uc2dd\uc5d0 \uc5f0\ub77d\ucc98 \uc815\ubcf4\ub97c \uc785\ub825\ud574 \uc8fc\uc2dc\uba74 \ubcf4\ud1b5 24\uc2dc\uac04 \uc774\ub0b4\uc5d0 \uc5f0\ub77d\ub4dc\ub9ac\uaca0\uc2b5\ub2c8\ub2e4. \uc774\uba54\uc77c\uc744 \ubcf4\ub0b4\uc154\ub3c4 \ub429\ub2c8\ub2e4.\u00a0<span style=\"color: #00ccff;\"><a style=\"color: #00ccff;\" href=\"mailto:info@longchangchemical.com\">info@longchangchemical.com<\/a><\/span>\u00a0\uadfc\ubb34 \uc2dc\uac04(\uc624\uc804 8\uc2dc 30\ubd84~\uc624\ud6c4 6\uc2dc, \uc6d4~\ud1a0\uc694\uc77c)\uc5d0 \ubb38\uc758\ud558\uac70\ub098 \uc6f9\uc0ac\uc774\ud2b8 \ub77c\uc774\ube0c \ucc44\ud305\uc744 \uc774\uc6a9\ud558\uba74 \uc2e0\uc18d\ud558\uac8c \ub2f5\ubcc0\uc744 \ubc1b\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/b><\/strong><\/h4>\n<table style=\"border-collapse: collapse; width: 326.27pt;\" border=\"0\" width=\"435\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt; width: 164.25pt;\" width=\"219\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/compound-glucoamylase-cas-9032-08-0\/\"><span style=\"color: #00ccff;\">\ubcf5\ud569 \uae00\ub8e8\ucf54\uc544\ubc00\ub77c\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\" style=\"width: 162.00pt;\" width=\"216\">9032-08-0<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/pullulanase-cas-9075-68-7\/\"><span style=\"color: #00ccff;\">\ud480\ub8f0\ub77c\ub098\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9075-68-7<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/xylanase-cas-37278-89-0\/\"><span style=\"color: #00ccff;\">\uc790\uc77c\ub77c\ub098\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">37278-89-0<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/cellulase-cas-9012-54-8\/\"><span style=\"color: #00ccff;\">\uc140\ub8f0\ub77c\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9012-54-8<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/naringinase-cas-9068-31-9\/\"><span style=\"color: #00ccff;\">\ub098\ub9b0\uae30\ub098\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9068-31-9<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/beta-amylase-cas-9000-91-3\/\"><span style=\"color: #00ccff;\">\u03b2-\uc544\ubc00\ub77c\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9000-91-3<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/glucose-oxidase-cas-9001-37-0\/\"><span style=\"color: #00ccff;\">\ud3ec\ub3c4\ub2f9 \uc0b0\ud654 \ud6a8\uc18c<\/span><\/a><\/td>\n<td class=\"et2\">9001-37-0<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\">\uc54c\ud30c-\uc544\ubc00\ub77c\uc544\uc81c<\/td>\n<td class=\"et2\">9000-90-2<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/longzyme-acid-pectinase-cas-9032-75-1\/\"><span style=\"color: #00ccff;\">\ud399\ud2f0\ub098\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9032-75-1<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\">\uacfc\uc0b0\ud654\ud6a8\uc18c<\/td>\n<td class=\"et2\">9003-99-0<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/lipase-cas-9001-62-1\/\"><span style=\"color: #00ccff;\">\ub9ac\ud30c\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9001-62-1<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/catalase-cas-9001-05-2\/\"><span style=\"color: #00ccff;\">\uce74\ud0c8\ub77c\uc544\uc81c<\/span><\/a><\/td>\n<td class=\"et4\">9001-05-2<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/tannase-cas-9025-71-2\/\"><span style=\"color: #00ccff;\">\ud0c4\ub098\uc138<\/span><\/a><\/td>\n<td class=\"et2\">9025-71-2<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/elastase-cas-39445-21-1\/\"><span style=\"color: #00ccff;\">\uc5d8\ub77c\uc2a4\ud0c0\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">39445-21-1<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/urease-cas-9002-13-5\/\"><span style=\"color: #00ccff;\">Urease<\/span><\/a><\/td>\n<td class=\"et2\">9002-13-5<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/dextranase-cas-9025-70-1\/\"><span style=\"color: #00ccff;\">\ub371\uc2a4\ud2b8\ub77c\ub098\uc81c<\/span><\/a><\/td>\n<td class=\"et2\">9025-70-1<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.5pt; text-align: left;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/l-lactic-dehydrogenase-cas-9001-60-9\/\"><span style=\"color: #00ccff;\">L-\ub77d\ud2b8 \ud0c8\uc218\uc18c \ud6a8\uc18c<\/span><\/a><\/td>\n<td class=\"et2\">9001-60-9<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/dehydrogenase-malate-cas-9001-64-3\/\"><span style=\"color: #00ccff;\">\ud0c8\uc218\uc18c \ud6a8\uc18c \ub9d0\ub808\uc774\ud2b8<\/span><\/a><\/td>\n<td class=\"et2\">9001-64-3<\/td>\n<\/tr>\n<tr style=\"height: 13.50pt;\">\n<td class=\"et2\" style=\"height: 13.50pt;\" height=\"18\"><a href=\"https:\/\/longchangchemical.com\/ko\/product\/cholesterol-oxidase-cas-9028-76-6\/\"><span style=\"color: #00ccff;\">\ucf5c\ub808\uc2a4\ud14c\ub864 \uc0b0\ud654 \ud6a8\uc18c<\/span><\/a><\/td>\n<td class=\"et2\">9028-76-6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>","protected":false},"excerpt":{"rendered":"<p>The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including molecular mechanics force-field and molecular dynamics simulations, quantum mechanics and combined<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-7255","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What is the computational chemistry approach in industrial enzyme research? - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/ko\/chemistry-approach-in-industrial-enzyme-research\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is the computational chemistry approach in industrial enzyme research? - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/ko\/chemistry-approach-in-industrial-enzyme-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-20T11:36:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:42:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"1000\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"What is the computational chemistry approach in industrial enzyme research?\",\"datePublished\":\"2024-08-20T11:36:15+00:00\",\"dateModified\":\"2026-04-28T10:42:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/\"},\"wordCount\":5506,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"ko-KR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/\",\"url\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/\",\"name\":\"What is the computational chemistry approach in industrial enzyme research? - Longchang Chemical\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/#website\"},\"datePublished\":\"2024-08-20T11:36:15+00:00\",\"dateModified\":\"2026-04-28T10:42:33+00:00\",\"description\":\"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...\",\"breadcrumb\":{\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#breadcrumb\"},\"inLanguage\":\"ko-KR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangchemical.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"What is the computational chemistry approach in industrial enzyme research?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangchemical.com\/#website\",\"url\":\"https:\/\/longchangchemical.com\/\",\"name\":\"Longchang Chemical\",\"description\":\"China chemical manufacturer \uff06 supplier\",\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangchemical.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ko-KR\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/longchangchemical.com\/#organization\",\"name\":\"Longchang Chemical\",\"url\":\"https:\/\/longchangchemical.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ko-KR\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"contentUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png\",\"width\":512,\"height\":512,\"caption\":\"Longchang Chemical\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\",\"name\":\"Longchang Chemical\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ko-KR\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"Longchang Chemical\"},\"sameAs\":[\"https:\/\/longchangchemical.com\"],\"url\":\"https:\/\/longchangchemical.com\/ko\/author\/infolongchangchemical-com\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0\uc11c \uacc4\uc0b0 \ud654\ud559\uc801 \uc811\uadfc \ubc29\uc2dd\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c? - \ub871\ucc3d\ucf00\ubbf8\uce7c","description":"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/ko\/chemistry-approach-in-industrial-enzyme-research\/","og_locale":"ko_KR","og_type":"article","og_title":"What is the computational chemistry approach in industrial enzyme research? - Longchang Chemical","og_description":"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...","og_url":"https:\/\/longchangchemical.com\/ko\/chemistry-approach-in-industrial-enzyme-research\/","og_site_name":"Longchang Chemical","article_published_time":"2024-08-20T11:36:15+00:00","article_modified_time":"2026-04-28T10:42:33+00:00","og_image":[{"width":1000,"height":1000,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2024\/02\/logo-jpeg.jpg","type":"image\/jpeg"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"What is the computational chemistry approach in industrial enzyme research?","datePublished":"2024-08-20T11:36:15+00:00","dateModified":"2026-04-28T10:42:33+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/"},"wordCount":5506,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"articleSection":["Enzyme News"],"inLanguage":"ko-KR"},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/","url":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/","name":"\uc0b0\uc5c5 \ud6a8\uc18c \uc5f0\uad6c\uc5d0\uc11c \uacc4\uc0b0 \ud654\ud559\uc801 \uc811\uadfc \ubc29\uc2dd\uc740 \ubb34\uc5c7\uc785\ub2c8\uae4c? - \ub871\ucc3d\ucf00\ubbf8\uce7c","isPartOf":{"@id":"https:\/\/longchangchemical.com\/#website"},"datePublished":"2024-08-20T11:36:15+00:00","dateModified":"2026-04-28T10:42:33+00:00","description":"The paper introduces the main computational chemistry methods used in industrial enzyme research, especially for guiding enzyme engineering, including m...","breadcrumb":{"@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#breadcrumb"},"inLanguage":"ko-KR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/longchangchemical.com\/chemistry-approach-in-industrial-enzyme-research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangchemical.com\/"},{"@type":"ListItem","position":2,"name":"What is the computational chemistry approach in industrial enzyme research?"}]},{"@type":"WebSite","@id":"https:\/\/longchangchemical.com\/#website","url":"https:\/\/longchangchemical.com\/","name":"\ub871\ucc3d\ucf00\ubbf8\uce7c","description":"\uc911\uad6d \ud654\ud559 \uc81c\uc870\uc5c5\uccb4 \uff06 \uacf5\uae09 \uc5c5\uccb4","publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangchemical.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ko-KR"},{"@type":"Organization","@id":"https:\/\/longchangchemical.com\/#organization","name":"\ub871\ucc3d\ucf00\ubbf8\uce7c","url":"https:\/\/longchangchemical.com\/","logo":{"@type":"ImageObject","inLanguage":"ko-KR","@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/","url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","contentUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2020\/08\/cropped-longchang-logo.png","width":512,"height":512,"caption":"Longchang Chemical"},"image":{"@id":"https:\/\/longchangchemical.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e","name":"\ub871\ucc3d\ucf00\ubbf8\uce7c","image":{"@type":"ImageObject","inLanguage":"ko-KR","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"Longchang Chemical"},"sameAs":["https:\/\/longchangchemical.com"],"url":"https:\/\/longchangchemical.com\/ko\/author\/infolongchangchemical-com\/"}]}},"_links":{"self":[{"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/posts\/7255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/comments?post=7255"}],"version-history":[{"count":6,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/posts\/7255\/revisions"}],"predecessor-version":[{"id":9819,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/posts\/7255\/revisions\/9819"}],"wp:attachment":[{"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/media?parent=7255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/categories?post=7255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangchemical.com\/ko\/wp-json\/wp\/v2\/tags?post=7255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}