A rutin, m\u00e1s n\u00e9ven P-vitamin, molekul\u00e1ris k\u00e9plete C27<\/sub>H30<\/sub>O16<\/sub>. A rutin k\u00e9miai szerkezete az 1. \u00e1br\u00e1n l\u00e1that\u00f3. Ez egy term\u00e9szetes flavonoid glikozid, amely gyullad\u00e1scs\u00f6kkent\u0151, antioxid\u00e1ns, antiallergi\u00e1s \u00e9s v\u00edrusellenes hat\u00e1ssal rendelkezik. A rutin olvad\u00e1spontja k\u00f6r\u00fclbel\u00fcl 178 \u2103, \u00e9s szobah\u0151m\u00e9rs\u00e9kleten s\u00e1rga krist\u00e1ly. F\u00e9ny hat\u00e1s\u00e1ra s\u00f6t\u00e9tebb sz\u00edn\u0171v\u00e9 v\u00e1lik, \u00e9s keserny\u00e9s \u00edze van. V\u00edzben kev\u00e9ss\u00e9 old\u00f3dik, metanolban, etanolban k\u00f6nnyen old\u00f3dik, alacsony polarit\u00e1s\u00fa szerves reagensekben, p\u00e9ld\u00e1ul petr\u00f3leum\u00e9terben nem old\u00f3dik. A rutin sz\u00e9les k\u00f6rben megtal\u00e1lhat\u00f3 a n\u00f6v\u00e9nyek gy\u00f6ker\u00e9ben, sz\u00e1r\u00e1ban, level\u00e9ben \u00e9s egy\u00e9b r\u00e9szeiben, \u00e9s tartalma magasabb az olyan n\u00f6v\u00e9nyekben, mint a Sophora japonicus, a rutinos gy\u00f3gyn\u00f6v\u00e9ny, az Eclipta prostrata \u00e9s a hajdina. Jelenleg a rutint az ipari termel\u00e9sben f\u0151k\u00e9nt a Sophora japonic\u00e1b\u00f3l vonj\u00e1k ki, \u00e9s tartalma meghaladhatja a 23,0%-t is. A f\u00f6ldrajzi eloszl\u00e1st tekintve a Sophora japonica rutintartalma Henan, Shandong \u00e9s Hebei tartom\u00e1nyokban magasabb. Ezenk\u00edv\u00fcl egyes tanulm\u00e1nyok kimutatt\u00e1k, hogy a hajdina, a v\u00f6r\u00f6s datolya, az eperfa levelei \u00e9s m\u00e1s n\u00f6v\u00e9nyek is tartalmaznak bizonyos mennyis\u00e9g\u0171 rutint.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\")
<\/figure>\r\n\r\n\r\n\r\n1. \u00e1bra A rutin k\u00e9miai szerkezete<\/h5>\r\n\r\n\r\n\r\nAz isoquercitrin, m\u00e1s n\u00e9ven apocynum A, a rutin derhamnosilb\u00f3l sz\u00e1rmaz\u00f3 sz\u00e1rmaz\u00e9ka. Molekul\u00e1ris k\u00e9plete: C21<\/sub>H20<\/sub>O12<\/sub>. Az izokeritrin k\u00e9miai szerkezete a 2. \u00e1br\u00e1n l\u00e1that\u00f3. Az izoquercitrin olvad\u00e1spontja k\u00f6r\u00fclbel\u00fcl 226 \u00b0C, \u00e9s szobah\u0151m\u00e9rs\u00e9kleten s\u00e1rga krist\u00e1ly. V\u00edzben val\u00f3 oldhat\u00f3s\u00e1ga alacsony, szobah\u0151m\u00e9rs\u00e9kleten mind\u00f6ssze 25,9 mg\/l. L\u00fagos v\u00edzben oldva s\u00f6t\u00e9tebb\u00e9 v\u00e1lik. Az izoquercitrin sz\u00e9les k\u00f6rben elterjedt a n\u00f6v\u00e9nyekben, bele\u00e9rtve a Saururus chinensis, Houttuynia cordata, Rhododendron aranylev\u00e9l, rododendron, Ginkgo biloba, Morus mulberry \u00e9s Elaeagnus homokt\u00f6vis stb. Az izokeritrin term\u00e9szetes tartalma a n\u00f6v\u00e9nyekben azonban alacsony, \u00e1tlagosan csak n\u00e9h\u00e1ny t\u00edzezrel\u00e9k, ez\u00e9rt t\u00f6bbnyire szintetikus m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa l\u00e9nyegesen nagyobb, mint a rutin\u00e9, \u00e9s gy\u00f3gy\u00e1szati \u00e9rt\u00e9ke magasabb.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-2.png\")
<\/figure>\r\n\r\n\r\n\r\n2. \u00e1bra Az izokeritrin k\u00e9miai szerkezete<\/h5>\r\n\r\n\r\n\r\n2. Az izokeritrin el\u0151\u00e1ll\u00edt\u00e1sa<\/h3>\r\n\r\n\r\n\r\nAz izoquercitrin term\u00e9szetes tartalma alacsony a n\u00f6v\u00e9nyekben, \u00e9s az iparban gyakran savas hidrol\u00edzissel, nagynyom\u00e1s\u00fa hidrol\u00edzissel \u00e9s m\u00e1s m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A vizsg\u00e1latok oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1ltak az izokeritrin monomer elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re n\u00f6v\u00e9nyi kivonatokb\u00f3l. P\u00e9ld\u00e1ul Shi Xin \u00e9s munkat\u00e1rsai f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t haszn\u00e1ltak a Yidianhong gy\u00f3gy\u00e1szati anyagokb\u00f3l > 98,0% tisztas\u00e1g\u00fa izoquercitrin elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re; Yin Li makropor\u00f3zus gyanta oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1lt f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1val kombin\u00e1lva, hogy 580 mg Huangdingju 9,3 mg izoquercitrint izol\u00e1ljanak az alkoholos kivonatb\u00f3l, \u00e9s tisztas\u00e1ga 95,8% volt. A n\u00f6v\u00e9nyek alacsony term\u00e9szetes izokeritrin-tartalma miatt azonban ez a m\u00f3dszer nemcsak alacsony hozam\u00fa, hanem nagy munkaterhel\u00e9ssel \u00e9s sok reagensfogyaszt\u00e1ssal is j\u00e1r, ami nagym\u00e9rt\u00e9kben korl\u00e1tozza az ipari gyakorlatban val\u00f3 alkalmaz\u00e1s\u00e1t. Yu Ting \u00e9s munkat\u00e1rsai a nagynyom\u00e1s\u00fa hidrol\u00edzist SG64 gyanta kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technol\u00f3gi\u00e1val kombin\u00e1lt\u00e1k az izokeritrin gyors el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer\u00e9nek l\u00e9trehoz\u00e1s\u00e1hoz. A hidrol\u00edzis k\u00f6r\u00fclm\u00e9nyei azonban nem k\u00f6nnyen szab\u00e1lyozhat\u00f3k, \u00e9s az izokeritrin hozama alacsony. A term\u00e9k nagy mennyis\u00e9g\u0171 hidroliz\u00e1latlan rutint \u00e9s tov\u00e1bbi hidrol\u00edzissel nyert kvercetint tartalmaz, ami megnehez\u00edti a k\u00e9s\u0151bbi elv\u00e1laszt\u00e1st.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-1.png\")
<\/figure>\r\n\r\n\r\n\r\nA biotechnol\u00f3gia, p\u00e9ld\u00e1ul a mikrobi\u00e1lis \u00e1talak\u00edt\u00e1s \u00e9s az enzimkataliz\u00e1lt \u00e1talak\u00edt\u00e1s l\u00e9nyeg\u00e9ben olyan anyagcsere-reakci\u00f3, amely szabad enzimeket vagy komplex enzimeket haszn\u00e1l az idegen vegy\u00fcletek szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1ra. El\u0151nyei az enyhe k\u00f6r\u00fclm\u00e9nyek, az er\u0151s szelektivit\u00e1s, a kev\u00e9s mell\u00e9kterm\u00e9k, a tiszta \u00e9s k\u00f6rnyezetbar\u00e1t, valamint az alacsony k\u00f6lts\u00e9g; term\u00e9szetes; A glikozid vegy\u00fcletek \u00e1ltal\u00e1ban t\u00f6bb glikozilcsoportot tartalmaznak \u00e9s nagyon pol\u00e1risak, \u00edgy nem a legjobb szerkezetek a farmakol\u00f3giai aktivit\u00e1suk kifejt\u00e9s\u00e9re. Alacsony glikozidokk\u00e1, aglikonokk\u00e1 vagy m\u00e1s term\u00e9kekk\u00e9 val\u00f3 \u00e1talak\u00edt\u00e1suk seg\u00edt a hat\u00e9konys\u00e1guk jobb kifejt\u00e9s\u00e9ben. Wang Yuanyuan \u00e9s munkat\u00e1rsai Streptomyces griseus-t haszn\u00e1ltak a rutin biotranszform\u00e1l\u00e1s\u00e1ra, \u00e9s szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1val elk\u00fcl\u00f6n\u00edtettek 6 \u00e1talakul\u00e1si term\u00e9ket, k\u00f6zt\u00fck az izokeritrint. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a folyamatban r\u00e9szt vev\u0151 reakci\u00f3k bonyolultabbak, bele\u00e9rtve a metil\u00e1l\u00e1st \u00e9s a glikozid-hidrol\u00edzist stb., ami azt jelzi, hogy a Streptomyces griseus gyenge specificit\u00e1ssal rendelkezik a rutin \u00e1talak\u00edt\u00e1s\u00e1ra.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter.png\")
<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-2.png\")
<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\n1. \u00e1bra A rutin k\u00e9miai szerkezete<\/h5>\r\n\r\n\r\n\r\nAz isoquercitrin, m\u00e1s n\u00e9ven apocynum A, a rutin derhamnosilb\u00f3l sz\u00e1rmaz\u00f3 sz\u00e1rmaz\u00e9ka. Molekul\u00e1ris k\u00e9plete: C21<\/sub>H20<\/sub>O12<\/sub>. Az izokeritrin k\u00e9miai szerkezete a 2. \u00e1br\u00e1n l\u00e1that\u00f3. Az izoquercitrin olvad\u00e1spontja k\u00f6r\u00fclbel\u00fcl 226 \u00b0C, \u00e9s szobah\u0151m\u00e9rs\u00e9kleten s\u00e1rga krist\u00e1ly. V\u00edzben val\u00f3 oldhat\u00f3s\u00e1ga alacsony, szobah\u0151m\u00e9rs\u00e9kleten mind\u00f6ssze 25,9 mg\/l. L\u00fagos v\u00edzben oldva s\u00f6t\u00e9tebb\u00e9 v\u00e1lik. Az izoquercitrin sz\u00e9les k\u00f6rben elterjedt a n\u00f6v\u00e9nyekben, bele\u00e9rtve a Saururus chinensis, Houttuynia cordata, Rhododendron aranylev\u00e9l, rododendron, Ginkgo biloba, Morus mulberry \u00e9s Elaeagnus homokt\u00f6vis stb. Az izokeritrin term\u00e9szetes tartalma a n\u00f6v\u00e9nyekben azonban alacsony, \u00e1tlagosan csak n\u00e9h\u00e1ny t\u00edzezrel\u00e9k, ez\u00e9rt t\u00f6bbnyire szintetikus m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa l\u00e9nyegesen nagyobb, mint a rutin\u00e9, \u00e9s gy\u00f3gy\u00e1szati \u00e9rt\u00e9ke magasabb.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\n2. \u00e1bra Az izokeritrin k\u00e9miai szerkezete<\/h5>\r\n\r\n\r\n\r\n2. Az izokeritrin el\u0151\u00e1ll\u00edt\u00e1sa<\/h3>\r\n\r\n\r\n\r\nAz izoquercitrin term\u00e9szetes tartalma alacsony a n\u00f6v\u00e9nyekben, \u00e9s az iparban gyakran savas hidrol\u00edzissel, nagynyom\u00e1s\u00fa hidrol\u00edzissel \u00e9s m\u00e1s m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A vizsg\u00e1latok oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1ltak az izokeritrin monomer elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re n\u00f6v\u00e9nyi kivonatokb\u00f3l. P\u00e9ld\u00e1ul Shi Xin \u00e9s munkat\u00e1rsai f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t haszn\u00e1ltak a Yidianhong gy\u00f3gy\u00e1szati anyagokb\u00f3l > 98,0% tisztas\u00e1g\u00fa izoquercitrin elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re; Yin Li makropor\u00f3zus gyanta oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1lt f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1val kombin\u00e1lva, hogy 580 mg Huangdingju 9,3 mg izoquercitrint izol\u00e1ljanak az alkoholos kivonatb\u00f3l, \u00e9s tisztas\u00e1ga 95,8% volt. A n\u00f6v\u00e9nyek alacsony term\u00e9szetes izokeritrin-tartalma miatt azonban ez a m\u00f3dszer nemcsak alacsony hozam\u00fa, hanem nagy munkaterhel\u00e9ssel \u00e9s sok reagensfogyaszt\u00e1ssal is j\u00e1r, ami nagym\u00e9rt\u00e9kben korl\u00e1tozza az ipari gyakorlatban val\u00f3 alkalmaz\u00e1s\u00e1t. Yu Ting \u00e9s munkat\u00e1rsai a nagynyom\u00e1s\u00fa hidrol\u00edzist SG64 gyanta kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technol\u00f3gi\u00e1val kombin\u00e1lt\u00e1k az izokeritrin gyors el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer\u00e9nek l\u00e9trehoz\u00e1s\u00e1hoz. A hidrol\u00edzis k\u00f6r\u00fclm\u00e9nyei azonban nem k\u00f6nnyen szab\u00e1lyozhat\u00f3k, \u00e9s az izokeritrin hozama alacsony. A term\u00e9k nagy mennyis\u00e9g\u0171 hidroliz\u00e1latlan rutint \u00e9s tov\u00e1bbi hidrol\u00edzissel nyert kvercetint tartalmaz, ami megnehez\u00edti a k\u00e9s\u0151bbi elv\u00e1laszt\u00e1st.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotechnol\u00f3gia, p\u00e9ld\u00e1ul a mikrobi\u00e1lis \u00e1talak\u00edt\u00e1s \u00e9s az enzimkataliz\u00e1lt \u00e1talak\u00edt\u00e1s l\u00e9nyeg\u00e9ben olyan anyagcsere-reakci\u00f3, amely szabad enzimeket vagy komplex enzimeket haszn\u00e1l az idegen vegy\u00fcletek szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1ra. El\u0151nyei az enyhe k\u00f6r\u00fclm\u00e9nyek, az er\u0151s szelektivit\u00e1s, a kev\u00e9s mell\u00e9kterm\u00e9k, a tiszta \u00e9s k\u00f6rnyezetbar\u00e1t, valamint az alacsony k\u00f6lts\u00e9g; term\u00e9szetes; A glikozid vegy\u00fcletek \u00e1ltal\u00e1ban t\u00f6bb glikozilcsoportot tartalmaznak \u00e9s nagyon pol\u00e1risak, \u00edgy nem a legjobb szerkezetek a farmakol\u00f3giai aktivit\u00e1suk kifejt\u00e9s\u00e9re. Alacsony glikozidokk\u00e1, aglikonokk\u00e1 vagy m\u00e1s term\u00e9kekk\u00e9 val\u00f3 \u00e1talak\u00edt\u00e1suk seg\u00edt a hat\u00e9konys\u00e1guk jobb kifejt\u00e9s\u00e9ben. Wang Yuanyuan \u00e9s munkat\u00e1rsai Streptomyces griseus-t haszn\u00e1ltak a rutin biotranszform\u00e1l\u00e1s\u00e1ra, \u00e9s szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1val elk\u00fcl\u00f6n\u00edtettek 6 \u00e1talakul\u00e1si term\u00e9ket, k\u00f6zt\u00fck az izokeritrint. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a folyamatban r\u00e9szt vev\u0151 reakci\u00f3k bonyolultabbak, bele\u00e9rtve a metil\u00e1l\u00e1st \u00e9s a glikozid-hidrol\u00edzist stb., ami azt jelzi, hogy a Streptomyces griseus gyenge specificit\u00e1ssal rendelkezik a rutin \u00e1talak\u00edt\u00e1s\u00e1ra.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\n2. \u00e1bra Az izokeritrin k\u00e9miai szerkezete<\/h5>\r\n\r\n\r\n\r\n2. Az izokeritrin el\u0151\u00e1ll\u00edt\u00e1sa<\/h3>\r\n\r\n\r\n\r\nAz izoquercitrin term\u00e9szetes tartalma alacsony a n\u00f6v\u00e9nyekben, \u00e9s az iparban gyakran savas hidrol\u00edzissel, nagynyom\u00e1s\u00fa hidrol\u00edzissel \u00e9s m\u00e1s m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A vizsg\u00e1latok oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1ltak az izokeritrin monomer elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re n\u00f6v\u00e9nyi kivonatokb\u00f3l. P\u00e9ld\u00e1ul Shi Xin \u00e9s munkat\u00e1rsai f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t haszn\u00e1ltak a Yidianhong gy\u00f3gy\u00e1szati anyagokb\u00f3l > 98,0% tisztas\u00e1g\u00fa izoquercitrin elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re; Yin Li makropor\u00f3zus gyanta oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1lt f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1val kombin\u00e1lva, hogy 580 mg Huangdingju 9,3 mg izoquercitrint izol\u00e1ljanak az alkoholos kivonatb\u00f3l, \u00e9s tisztas\u00e1ga 95,8% volt. A n\u00f6v\u00e9nyek alacsony term\u00e9szetes izokeritrin-tartalma miatt azonban ez a m\u00f3dszer nemcsak alacsony hozam\u00fa, hanem nagy munkaterhel\u00e9ssel \u00e9s sok reagensfogyaszt\u00e1ssal is j\u00e1r, ami nagym\u00e9rt\u00e9kben korl\u00e1tozza az ipari gyakorlatban val\u00f3 alkalmaz\u00e1s\u00e1t. Yu Ting \u00e9s munkat\u00e1rsai a nagynyom\u00e1s\u00fa hidrol\u00edzist SG64 gyanta kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technol\u00f3gi\u00e1val kombin\u00e1lt\u00e1k az izokeritrin gyors el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer\u00e9nek l\u00e9trehoz\u00e1s\u00e1hoz. A hidrol\u00edzis k\u00f6r\u00fclm\u00e9nyei azonban nem k\u00f6nnyen szab\u00e1lyozhat\u00f3k, \u00e9s az izokeritrin hozama alacsony. A term\u00e9k nagy mennyis\u00e9g\u0171 hidroliz\u00e1latlan rutint \u00e9s tov\u00e1bbi hidrol\u00edzissel nyert kvercetint tartalmaz, ami megnehez\u00edti a k\u00e9s\u0151bbi elv\u00e1laszt\u00e1st.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotechnol\u00f3gia, p\u00e9ld\u00e1ul a mikrobi\u00e1lis \u00e1talak\u00edt\u00e1s \u00e9s az enzimkataliz\u00e1lt \u00e1talak\u00edt\u00e1s l\u00e9nyeg\u00e9ben olyan anyagcsere-reakci\u00f3, amely szabad enzimeket vagy komplex enzimeket haszn\u00e1l az idegen vegy\u00fcletek szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1ra. El\u0151nyei az enyhe k\u00f6r\u00fclm\u00e9nyek, az er\u0151s szelektivit\u00e1s, a kev\u00e9s mell\u00e9kterm\u00e9k, a tiszta \u00e9s k\u00f6rnyezetbar\u00e1t, valamint az alacsony k\u00f6lts\u00e9g; term\u00e9szetes; A glikozid vegy\u00fcletek \u00e1ltal\u00e1ban t\u00f6bb glikozilcsoportot tartalmaznak \u00e9s nagyon pol\u00e1risak, \u00edgy nem a legjobb szerkezetek a farmakol\u00f3giai aktivit\u00e1suk kifejt\u00e9s\u00e9re. Alacsony glikozidokk\u00e1, aglikonokk\u00e1 vagy m\u00e1s term\u00e9kekk\u00e9 val\u00f3 \u00e1talak\u00edt\u00e1suk seg\u00edt a hat\u00e9konys\u00e1guk jobb kifejt\u00e9s\u00e9ben. Wang Yuanyuan \u00e9s munkat\u00e1rsai Streptomyces griseus-t haszn\u00e1ltak a rutin biotranszform\u00e1l\u00e1s\u00e1ra, \u00e9s szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1val elk\u00fcl\u00f6n\u00edtettek 6 \u00e1talakul\u00e1si term\u00e9ket, k\u00f6zt\u00fck az izokeritrint. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a folyamatban r\u00e9szt vev\u0151 reakci\u00f3k bonyolultabbak, bele\u00e9rtve a metil\u00e1l\u00e1st \u00e9s a glikozid-hidrol\u00edzist stb., ami azt jelzi, hogy a Streptomyces griseus gyenge specificit\u00e1ssal rendelkezik a rutin \u00e1talak\u00edt\u00e1s\u00e1ra.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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Az izoquercitrin term\u00e9szetes tartalma alacsony a n\u00f6v\u00e9nyekben, \u00e9s az iparban gyakran savas hidrol\u00edzissel, nagynyom\u00e1s\u00fa hidrol\u00edzissel \u00e9s m\u00e1s m\u00f3dszerekkel \u00e1ll\u00edtj\u00e1k el\u0151. A vizsg\u00e1latok oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1ltak az izokeritrin monomer elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re n\u00f6v\u00e9nyi kivonatokb\u00f3l. P\u00e9ld\u00e1ul Shi Xin \u00e9s munkat\u00e1rsai f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1t haszn\u00e1ltak a Yidianhong gy\u00f3gy\u00e1szati anyagokb\u00f3l > 98,0% tisztas\u00e1g\u00fa izoquercitrin elk\u00fcl\u00f6n\u00edt\u00e9s\u00e9re; Yin Li makropor\u00f3zus gyanta oszlopkromatogr\u00e1fi\u00e1t haszn\u00e1lt f\u00e9lpreparat\u00edv nagy teljes\u00edtm\u00e9ny\u0171 folyad\u00e9kkromatogr\u00e1fi\u00e1val kombin\u00e1lva, hogy 580 mg Huangdingju 9,3 mg izoquercitrint izol\u00e1ljanak az alkoholos kivonatb\u00f3l, \u00e9s tisztas\u00e1ga 95,8% volt. A n\u00f6v\u00e9nyek alacsony term\u00e9szetes izokeritrin-tartalma miatt azonban ez a m\u00f3dszer nemcsak alacsony hozam\u00fa, hanem nagy munkaterhel\u00e9ssel \u00e9s sok reagensfogyaszt\u00e1ssal is j\u00e1r, ami nagym\u00e9rt\u00e9kben korl\u00e1tozza az ipari gyakorlatban val\u00f3 alkalmaz\u00e1s\u00e1t. Yu Ting \u00e9s munkat\u00e1rsai a nagynyom\u00e1s\u00fa hidrol\u00edzist SG64 gyanta kromatogr\u00e1fi\u00e1s elv\u00e1laszt\u00e1si technol\u00f3gi\u00e1val kombin\u00e1lt\u00e1k az izokeritrin gyors el\u0151\u00e1ll\u00edt\u00e1si m\u00f3dszer\u00e9nek l\u00e9trehoz\u00e1s\u00e1hoz. A hidrol\u00edzis k\u00f6r\u00fclm\u00e9nyei azonban nem k\u00f6nnyen szab\u00e1lyozhat\u00f3k, \u00e9s az izokeritrin hozama alacsony. A term\u00e9k nagy mennyis\u00e9g\u0171 hidroliz\u00e1latlan rutint \u00e9s tov\u00e1bbi hidrol\u00edzissel nyert kvercetint tartalmaz, ami megnehez\u00edti a k\u00e9s\u0151bbi elv\u00e1laszt\u00e1st.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA biotechnol\u00f3gia, p\u00e9ld\u00e1ul a mikrobi\u00e1lis \u00e1talak\u00edt\u00e1s \u00e9s az enzimkataliz\u00e1lt \u00e1talak\u00edt\u00e1s l\u00e9nyeg\u00e9ben olyan anyagcsere-reakci\u00f3, amely szabad enzimeket vagy komplex enzimeket haszn\u00e1l az idegen vegy\u00fcletek szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1ra. El\u0151nyei az enyhe k\u00f6r\u00fclm\u00e9nyek, az er\u0151s szelektivit\u00e1s, a kev\u00e9s mell\u00e9kterm\u00e9k, a tiszta \u00e9s k\u00f6rnyezetbar\u00e1t, valamint az alacsony k\u00f6lts\u00e9g; term\u00e9szetes; A glikozid vegy\u00fcletek \u00e1ltal\u00e1ban t\u00f6bb glikozilcsoportot tartalmaznak \u00e9s nagyon pol\u00e1risak, \u00edgy nem a legjobb szerkezetek a farmakol\u00f3giai aktivit\u00e1suk kifejt\u00e9s\u00e9re. Alacsony glikozidokk\u00e1, aglikonokk\u00e1 vagy m\u00e1s term\u00e9kekk\u00e9 val\u00f3 \u00e1talak\u00edt\u00e1suk seg\u00edt a hat\u00e9konys\u00e1guk jobb kifejt\u00e9s\u00e9ben. Wang Yuanyuan \u00e9s munkat\u00e1rsai Streptomyces griseus-t haszn\u00e1ltak a rutin biotranszform\u00e1l\u00e1s\u00e1ra, \u00e9s szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1val elk\u00fcl\u00f6n\u00edtettek 6 \u00e1talakul\u00e1si term\u00e9ket, k\u00f6zt\u00fck az izokeritrint. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a folyamatban r\u00e9szt vev\u0151 reakci\u00f3k bonyolultabbak, bele\u00e9rtve a metil\u00e1l\u00e1st \u00e9s a glikozid-hidrol\u00edzist stb., ami azt jelzi, hogy a Streptomyces griseus gyenge specificit\u00e1ssal rendelkezik a rutin \u00e1talak\u00edt\u00e1s\u00e1ra.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nA biotechnol\u00f3gia, p\u00e9ld\u00e1ul a mikrobi\u00e1lis \u00e1talak\u00edt\u00e1s \u00e9s az enzimkataliz\u00e1lt \u00e1talak\u00edt\u00e1s l\u00e9nyeg\u00e9ben olyan anyagcsere-reakci\u00f3, amely szabad enzimeket vagy komplex enzimeket haszn\u00e1l az idegen vegy\u00fcletek szerkezet\u00e9nek m\u00f3dos\u00edt\u00e1s\u00e1ra. El\u0151nyei az enyhe k\u00f6r\u00fclm\u00e9nyek, az er\u0151s szelektivit\u00e1s, a kev\u00e9s mell\u00e9kterm\u00e9k, a tiszta \u00e9s k\u00f6rnyezetbar\u00e1t, valamint az alacsony k\u00f6lts\u00e9g; term\u00e9szetes; A glikozid vegy\u00fcletek \u00e1ltal\u00e1ban t\u00f6bb glikozilcsoportot tartalmaznak \u00e9s nagyon pol\u00e1risak, \u00edgy nem a legjobb szerkezetek a farmakol\u00f3giai aktivit\u00e1suk kifejt\u00e9s\u00e9re. Alacsony glikozidokk\u00e1, aglikonokk\u00e1 vagy m\u00e1s term\u00e9kekk\u00e9 val\u00f3 \u00e1talak\u00edt\u00e1suk seg\u00edt a hat\u00e9konys\u00e1guk jobb kifejt\u00e9s\u00e9ben. Wang Yuanyuan \u00e9s munkat\u00e1rsai Streptomyces griseus-t haszn\u00e1ltak a rutin biotranszform\u00e1l\u00e1s\u00e1ra, \u00e9s szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1val elk\u00fcl\u00f6n\u00edtettek 6 \u00e1talakul\u00e1si term\u00e9ket, k\u00f6zt\u00fck az izokeritrint. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy az ebben a folyamatban r\u00e9szt vev\u0151 reakci\u00f3k bonyolultabbak, bele\u00e9rtve a metil\u00e1l\u00e1st \u00e9s a glikozid-hidrol\u00edzist stb., ami azt jelzi, hogy a Streptomyces griseus gyenge specificit\u00e1ssal rendelkezik a rutin \u00e1talak\u00edt\u00e1s\u00e1ra.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nAz enzimatikus hidrol\u00edzis m\u00f3dszer el\u0151nyei k\u00f6z\u00e9 tartozik az enyhe reakci\u00f3k\u00f6r\u00fclm\u00e9nyek, az er\u0151s specificit\u00e1s \u00e9s a reakci\u00f3 k\u00f6nny\u0171 ir\u00e1ny\u00edthat\u00f3s\u00e1ga, \u00e9s a fent eml\u00edtett m\u00f3dszer hi\u00e1nyoss\u00e1gait az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1ra k\u00e9pes kik\u00fcsz\u00f6b\u00f6lni. P\u00e9ld\u00e1ul Wu Di \u00e9s munkat\u00e1rsai mikroorganizmusok \u00e1ltal termelt \u03b1-L-ramnosid\u00e1zt haszn\u00e1ltak a rutin \u00e1talak\u00edt\u00e1s\u00e1ra; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izokeritrin hozama 49,4% volt, \u00e9s tisztas\u00e1ga szilikag\u00e9l oszlopkromatogr\u00e1fi\u00e1s tiszt\u00edt\u00e1s ut\u00e1n el\u00e9rte a 98,3%-t. Sun Guoxia \u00e9s munkat\u00e1rsai a rutin hidroliz\u00e1l\u00e1s\u00e1hoz hesperidin\u00e1zt haszn\u00e1ltak az izokeritrin el\u0151\u00e1ll\u00edt\u00e1s\u00e1hoz, \u00e9s ionos folyad\u00e9kokat haszn\u00e1ltak az izokeritrin hozam\u00e1nak n\u00f6vel\u00e9s\u00e9re. A v\u00e9gterm\u00e9k konverzi\u00f3s ar\u00e1nya el\u00e9rte a 99,27 \u00b1 0,55% \u00e9rt\u00e9ket.<\/h5>\r\n\r\n\r\n\r\n3. A rutin \u00e9s az izoquercitrin farmakol\u00f3giai tev\u00e9kenys\u00e9g\u00e9nek bemutat\u00e1sa<\/h3>\r\n\r\n\r\n\r\nA rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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A rutin a hagyom\u00e1nyos k\u00ednai gy\u00f3gy\u00e1szatban a s\u00e1fr\u00e1nyvir\u00e1g \u00e9s m\u00e1s gy\u00f3gyszerek fontos \u00f6sszetev\u0151je a v\u00e9rkering\u00e9s el\u0151seg\u00edt\u00e9s\u00e9re \u00e9s a v\u00e9r pang\u00e1s\u00e1nak megsz\u00fcntet\u00e9s\u00e9re. Bizonyos hat\u00e1ssal van a sz\u00edv- \u00e9s \u00e9rrendszeri \u00e9s agyi \u00e9rrendszeri betegs\u00e9gekre, p\u00e9ld\u00e1ul az agyi tromb\u00f3zisra \u00e9s az angina pectorisra. Jin Ming \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy a rutin bizonyos koncentr\u00e1ci\u00f3ja antagoniz\u00e1lni tudja a v\u00e9rlemezke-aktiv\u00e1l\u00f3 faktor \u00e9s a ny\u00faltrombocita receptorok specifikus k\u00f6t\u0151d\u00e9s\u00e9t, ez\u00e1ltal g\u00e1tolja az aktiv\u00e1l\u00f3 faktor \u00e1ltal k\u00f6zvet\u00edtett v\u00e9rlemezke-adh\u00e9zi\u00f3t \u00e9s a szabad Ca2+<\/sup>\u00a0koncentr\u00e1ci\u00f3 a v\u00e9rlemezk\u00e9kben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nGuardia \u00e9s munkat\u00e1rsai h\u00e1rom flavonoidot, a hesperidint, a quercetint \u00e9s a rutint, valamint e h\u00e1rom flavonoid gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k patk\u00e1nyokon. El\u0151sz\u00f6r az akut \u00e9s kr\u00f3nikus gyullad\u00e1s patk\u00e1nymodellj\u00e9t \u00e1ll\u00edtott\u00e1k fel. A h\u00e1rom flavonoid 80 mg\/kg-d d\u00f3zisban t\u00f6rt\u00e9n\u0151 intraperitone\u00e1lis bead\u00e1sa ut\u00e1n a h\u00e1rom flavonoid k\u00e9pes g\u00e1tolni a k\u00eds\u00e9rleti gyullad\u00e1smodell akut \u00e9s kr\u00f3nikus f\u00e1zisait; k\u00f6z\u00fcl\u00fck a rutin a leger\u0151sebb hat\u00e1st a kr\u00f3nikus gyullad\u00e1sra fejtette ki. Yoo \u00e9s munkat\u00e1rsai a rutin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k a hum\u00e1n k\u00f6ld\u00f6kv\u00e9n\u00e1s endot\u00e9lsejtek (HUVEC) pro-inflammatorikus v\u00e1lasz\u00e1ra, amelyet a nagy mobilit\u00e1s\u00fa csoportfeh\u00e9rje 1 (HMGB1) \u00e9s a kapcsol\u00f3d\u00f3 jel\u00e1tviteli utak induk\u00e1ltak. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin k\u00e9pes g\u00e1tolni a HMGB1 felszabadul\u00e1s\u00e1t \u00e9s cs\u00f6kkenteni az eg\u00e9r leukocit\u00e1k migr\u00e1ci\u00f3j\u00e1t. Tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy a rutin g\u00e1tolni tudja a tumor nekr\u00f3zis faktor alfa \u00e9s az interleukin 6 HMGB1 \u00e1ltal induk\u00e1lt termel\u00e9s\u00e9t is, ami bizony\u00edtja, hogy a rutin a HMGB1 jel\u00e1tviteli \u00fatvonal g\u00e1tl\u00e1s\u00e1val k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyos vaszkulitiszes betegs\u00e9geket kezelhet.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nYang \u00e9s munkat\u00e1rsai megm\u00e9rt\u00e9k a rutin antioxid\u00e1ns aktivit\u00e1s\u00e1t, \u00e9s \u00f6sszehasonl\u00edtott\u00e1k a standard antioxid\u00e1ns butil-hidroxitoluol (BHT) \u00e9s az aszkorbinsav (Vc) antioxid\u00e1nsokkal. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin er\u0151s k\u00e9pess\u00e9ggel rendelkezik a DPPH szabadgy\u00f6k\u00f6k elnyel\u00e9s\u00e9re. Amikor a koncentr\u00e1ci\u00f3 0,05 mg\/ml, a Vc, a BHT \u00e9s a rutin g\u00e1tl\u00e1si ar\u00e1nya el\u00e9rheti a 92,8%, 58,8% \u00e9s 90,4% \u00e9rt\u00e9keket; ezen k\u00edv\u00fcl a rutin er\u0151s hat\u00e1ssal van a lipidekre. A min\u0151s\u00e9gi peroxid\u00e1ci\u00f3 szint\u00e9n jelent\u0151s g\u00e1tl\u00f3 hat\u00e1ssal b\u00edr.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro \u00e9s munkat\u00e1rsai a rutin citotoxikus hat\u00e1s\u00e1nak kimutat\u00e1s\u00e1ra az MTT-m\u00f3dszert alkalmazt\u00e1k emberi r\u00e1kos sejteken \u00e9s nem daganatos sejtvonalakon. A rutin k\u00fcl\u00f6nb\u00f6z\u0151 d\u00f3zisait 32 napon kereszt\u00fcl intraperitone\u00e1lisan fecskendezt\u00e9k be SW480 vastagb\u00e9lr\u00e1kot mutat\u00f3 nu\/nu egerekbe; elemezt\u00e9k a sz\u00e9rum vaszkul\u00e1ris endoteli\u00e1lis n\u00f6veked\u00e9si faktor (VEGF) szintj\u00e9t, a t\u00fal\u00e9l\u00e9si id\u0151t, valamint a testt\u00f6megre \u00e9s a szervek t\u00f6meg\u00e9re gyakorolt toxikol\u00f3giai hat\u00e1sokat. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy a rutin a legnagyobb citotoxikus hat\u00e1ssal rendelkezik az SW480 sejtekre (IC50 = 125 \u03bcM), \u00e9s nincs toxikus hat\u00e1sa az egerek m\u00e1s szerveire; a kezeletlen egerekhez k\u00e9pest az \u00e1tlagos t\u00fal\u00e9l\u00e9si id\u0151 50 nappal meghosszabbodik, \u00e9s a sz\u00e9rum VEGF szint A cs\u00f6kken\u00e9se 55%. Saleh \u00e9s munkat\u00e1rsai \u00f6sszehasonl\u00edtott\u00e1k a rutin \u00e9s az orlistat r\u00e1kellenes hat\u00e1s\u00e1t k\u00e9t eml\u0151r\u00e1kmodellre (in vivo EAC \u00e9s in vitro MCF7) \u00e9s hasny\u00e1lmirigyr\u00e1k-sejtvonalra (PANC-1). A tumor t\u00e9rfogata, a CEA (karcinoembri\u00f3 antig\u00e9n) szintje, a koleszterintartalom, a FAS antig\u00e9n, az antioxid\u00e1ns hat\u00e1s \u00e9s a sz\u00f6vettani vizsg\u00e1lat azt mutatta, hogy mind a rutin, mind az orlistat r\u00e1kellenes hat\u00e1ssal rendelkezik a szervezetben. Ezenk\u00edv\u00fcl mindkett\u0151 citotoxikus az MCF-7 \u00e9s PANC-1 sejtvonalakra az apopt\u00f3zis el\u0151seg\u00edt\u00e9s\u00e9vel.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nA modern farmakol\u00f3giai vizsg\u00e1latok kimutatt\u00e1k, hogy az izoquercitrin farmakol\u00f3giai aktivit\u00e1sa az antioxid\u00e1ci\u00f3, a daganatellenes \u00e9s egy\u00e9b vonatkoz\u00e1sokban jelent\u0151sen magasabb, mint a rutin\u00e9. Jung \u00e9s munkat\u00e1rsai h\u00e9t vegy\u00fcletet, \u00edgy az izoquercitrint izol\u00e1lt\u00e1k a Platycladus orientalisb\u00f3l, \u00e9s vizsg\u00e1lt\u00e1k antioxid\u00e1ns aktivit\u00e1sukat. Az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin hat\u00e1ssal van a hidrog\u00e9n-peroxid (H2<\/sub>O2<\/sub>). A sejtpusztul\u00e1s g\u00e1tl\u00f3 hat\u00e1sa a leger\u0151sebb. Ugyanakkor az izoquercitrin sz\u00e1jon \u00e1t toler\u00e1lhat\u00f3, \u00edgy olyan betegs\u00e9gek kezel\u00e9s\u00e9re is alkalmazhat\u00f3, mint a glauk\u00f3ma. Rogerio \u00e9s munkat\u00e1rsai a kvercetin \u00e9s az izokvercitrin gyullad\u00e1scs\u00f6kkent\u0151 hat\u00e1s\u00e1t vizsg\u00e1lt\u00e1k asztma eg\u00e9rmodelleken; az eredm\u00e9nyek azt mutatt\u00e1k, hogy ez a k\u00e9t flavonoid hat\u00e9kony eozinofil gyullad\u00e1sg\u00e1tl\u00f3, \u00e9s bizonyos potenci\u00e1llal rendelkezik az allergi\u00e1s betegs\u00e9gek kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nHuang \u00e9s munkat\u00e1rsai az izokeritrin m\u00e1jr\u00e1kra gyakorolt hat\u00e1s\u00e1nak mechanizmus\u00e1t vizsg\u00e1lt\u00e1k. In vitro k\u00eds\u00e9rletekben meg\u00e1llap\u00edtott\u00e1k, hogy az izokeritrin k\u00e9pes g\u00e1tolni a r\u00e1kos sejtek prolifer\u00e1ci\u00f3j\u00e1t, mik\u00f6zben el\u0151seg\u00edti apopt\u00f3zisukat, \u00e9s ugyanakkor cs\u00f6kkenti a PKC expresszi\u00f3s szintj\u00e9t az emberi m\u00e1jr\u00e1ksejtekben; in vivo k\u00eds\u00e9rletekben az izokeritrin transzplant\u00e1lt tumorokat is okozhat meztelen egerekben. A sejtek n\u00f6veked\u00e9si \u00fcteme jelent\u0151sen cs\u00f6kken. Meger\u0151s\u00edt\u00e9st nyert, hogy az izoquercitrin jelent\u0151sen g\u00e1tolni tudja a m\u00e1jr\u00e1k kialakul\u00e1s\u00e1t \u00e9s fejl\u0151d\u00e9s\u00e9t, \u00e9s molekul\u00e1ris mechanizmusa a PKC \u00e9s a MAPK jel\u00e1tviteli \u00fatvonalakkal \u00e1llhat \u00f6sszef\u00fcgg\u00e9sben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nJi Lili \u00f6sszehasonl\u00edtotta a Moringa oleifera levelek izoquercitrin \u00e9s \u00f6sszes flavonoidj\u00e1nak in vitro hipoglik\u00e9mi\u00e1s aktivit\u00e1s\u00e1t. Az eredm\u00e9nyek azt mutatj\u00e1k, hogy mindkett\u0151 k\u00e9pes jelent\u0151sen n\u00f6velni a HepG2 sejtek gl\u00fck\u00f3zfogyaszt\u00e1s\u00e1t, \u00e9s az izoquercitrin hipoglik\u00e9mi\u00e1s hat\u00e1sa jelent\u0151sen er\u0151sebb, mint az \u00f6sszes flavonoid\u00e9; tov\u00e1bbi vizsg\u00e1latok meg\u00e1llap\u00edtott\u00e1k, hogy hipoglik\u00e9mi\u00e1s mechanizmusa els\u0151sorban a DPP-4 aktivit\u00e1s\u00e1nak g\u00e1tl\u00e1s\u00e1val fokoz\u00f3dik, \u00e9s az inzulin szekr\u00e9ci\u00f3ja az InsR, PKA \u00e9s PKC\u03b1 expresszi\u00f3j\u00e1t is felszab\u00e1lyozza, ez\u00e1ltal fokozza az inzulin hat\u00e1s\u00e1t \u00e9s el\u0151seg\u00edti a m\u00e1j \u00e9s a hasny\u00e1lmirigy szigetsejtek prolifer\u00e1ci\u00f3j\u00e1t.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nYun \u00e9s munkat\u00e1rsai az izoquercitrin gombaellenes aktivit\u00e1s\u00e1t \u00e9s hat\u00e1smechanizmus\u00e1t t\u00e1rgyalt\u00e1k; az eredm\u00e9nyek azt mutatt\u00e1k, hogy az izoquercitrin er\u0151s hat\u00e1st fejt ki a patog\u00e9n gomb\u00e1k \u00e9rz\u00e9kenys\u00e9gi tesztj\u00e9ben, \u00e9s nem tal\u00e1ltak hemol\u00edzist. Ezenk\u00edv\u00fcl a candida albicans eset\u00e9ben is vizsg\u00e1lt\u00e1k a malonyl-jodid \u00e9s a k\u00e1lium felszabadul\u00e1s\u00e1t, ami meger\u0151s\u00edtette, hogy az izoquercitrin k\u00e9pes beavatkozni a sejtmembr\u00e1nba \u00e9s n\u00f6velni annak permeabilit\u00e1s\u00e1t, hogy el\u0151seg\u00edtse a membr\u00e1n k\u00e1rosod\u00e1s\u00e1t, ez\u00e1ltal antibakteri\u00e1lis hat\u00e1st fejt ki. Kim \u00e9s munkat\u00e1rsai meg\u00e1llap\u00edtott\u00e1k, hogy az izoquercitrin k\u00e9pes g\u00e1tolni az influenza A \u00e9s B v\u00edrusok szaporod\u00e1s\u00e1t, \u00e9s amantadinnal \u00e9s oszeltamivirrel egy\u00fctt alkalmazva hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t, ami azt jelzi, hogy az izoquercitrin hat\u00e9konyan g\u00e1tolja a rezisztens v\u00edrusok kialakul\u00e1s\u00e1t. Bizonyos alkalmaz\u00e1si lehet\u0151s\u00e9gekkel rendelkezik a v\u00edrusos influenza kezel\u00e9s\u00e9ben.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\nHa sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\n\u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nKatal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUre\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nDehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nKoleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"hu\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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Longchang Chemical","description":"Rem\u00e9lj\u00fck, hogy term\u00e9keinket vil\u00e1gszerte haszn\u00e1lj\u00e1k a tudom\u00e1ny \u00e9rdek\u00e9ben.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_locale":"hu_HU","og_type":"article","og_title":"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical","og_description":"We hope our products are used worldwide to enable science.","og_url":"https:\/\/longchangchemical.com\/hu\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","og_site_name":"Longchang Chemical","article_published_time":"2021-03-24T14:43:25+00:00","article_modified_time":"2026-04-28T10:41:49+00:00","og_image":[{"width":396,"height":230,"url":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","type":"image\/png"}],"author":"Longchang Chemical","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article","isPartOf":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"author":{"name":"Longchang Chemical","@id":"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e"},"headline":"Preparation and pharmacological activity of rutin and isoquercitrin","datePublished":"2021-03-24T14:43:25+00:00","dateModified":"2026-04-28T10:41:49+00:00","mainEntityOfPage":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/"},"wordCount":2138,"commentCount":0,"publisher":{"@id":"https:\/\/longchangchemical.com\/#organization"},"image":{"@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png","articleSection":["Enzyme News"],"inLanguage":"hu","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","url":"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/","name":"A rutin \u00e9s az izoquercitrin el\u0151\u00e1ll\u00edt\u00e1sa \u00e9s farmakol\u00f3giai aktivit\u00e1sa - 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<\/figure>\r\n\r\n\r\n\r\nA fenti hat\u00e1sok mellett az izokeritrin \u00e9lettani tev\u00e9kenys\u00e9get is kifejt, p\u00e9ld\u00e1ul csontritkul\u00e1s-ellenes, v\u00e9rnyom\u00e1s- \u00e9s v\u00e9rzs\u00edrcs\u00f6kkent\u0151, neuroprotekt\u00edv \u00e9s depresszi\u00f3ellenes. Az \u03b1-L-ramnozid\u00e1z alkalmaz\u00e1s\u00e1t a rutin biotranszform\u00e1ci\u00f3j\u00e1ban a k\u00e9s\u0151bbiekben mutatjuk be.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
- \n
- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n
- \n
- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nL\u00e9pjen kapcsolatba vel\u00fcnk most!<\/b><\/strong><\/h2>\r\n
Ha sz\u00fcks\u00e9ge van Price-ra, k\u00e9rj\u00fck, t\u00f6ltse ki el\u00e9rhet\u0151s\u00e9g\u00e9t az al\u00e1bbi \u0171rlapon, \u00e1ltal\u00e1ban 24 \u00f3r\u00e1n bel\u00fcl felvessz\u00fck \u00d6nnel a kapcsolatot. \u00d6n is k\u00fcldhet nekem e-mailt\u00a0info@longchangchemical.com<\/a><\/span>\u00a0munkaid\u0151ben ( 8:30-18:00 UTC+8 H.-Szombat ) vagy haszn\u00e1lja a weboldal \u00e9l\u0151 chatj\u00e9t, hogy azonnali v\u00e1laszt kapjon.<\/b><\/strong><\/h4>\r\n
\r\n\r\n
\r\n \u00d6sszet\u00e9tel Gl\u00fckoamil\u00e1z<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\n Pullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\n Xilan\u00e1z<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\n Cellul\u00e1z<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\n Naringin\u00e1z<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n \u03b2-Amil\u00e1z<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\n Gl\u00fck\u00f3z-oxid\u00e1z<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\n alfa-amil\u00e1z<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\n Pektin\u00e1z<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\n Peroxid\u00e1z<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\n Lip\u00e1z<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\n Katal\u00e1z<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\n TANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\n Elaszt\u00e1z<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\n Ure\u00e1z<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\n DEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\n L-laktil-dehidrogen\u00e1z<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\n Dehidrogen\u00e1z mal\u00e1t<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\n Koleszterin-oxid\u00e1z<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":" 1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n