La rutine, \u00e9galement connue sous le nom de vitamine P, a une formule mol\u00e9culaire de C27<\/sub>H30<\/sub>O16<\/sub>. La structure chimique de la rutine est pr\u00e9sent\u00e9e \u00e0 la figure 1. Il s'agit d'un glycoside flavono\u00efde naturel aux effets anti-inflammatoires, antioxydants, antiallergiques et antiviraux. Le point de fusion de la rutine est d'environ 178 \u2103, et c'est un cristal jaune \u00e0 temp\u00e9rature ambiante. Elle prend une couleur plus fonc\u00e9e lorsqu'elle est expos\u00e9e \u00e0 la lumi\u00e8re et a un go\u00fbt amer. Elle est peu soluble dans l'eau, facilement soluble dans le m\u00e9thanol et l'\u00e9thanol, et insoluble dans les r\u00e9actifs organiques de faible polarit\u00e9 tels que l'\u00e9ther de p\u00e9trole. La rutine est largement pr\u00e9sente dans les racines, les tiges, les feuilles et d'autres parties des plantes, et sa teneur est plus \u00e9lev\u00e9e dans des plantes telles que Sophora japonicus, Rutinous herb, Eclipta prostrata et le sarrasin. \u00c0 l'heure actuelle, la rutine est principalement extraite de Sophora japonica dans le cadre de la production industrielle, et sa teneur peut atteindre plus de 23,0%. En termes de r\u00e9partition g\u00e9ographique, la teneur en rutine de Sophora japonica est plus \u00e9lev\u00e9e dans les provinces de Henan, Shandong et Hebei. En outre, certaines \u00e9tudes ont montr\u00e9 que le sarrasin, les dattes rouges, les feuilles de m\u00fbrier et d'autres plantes contiennent \u00e9galement une certaine quantit\u00e9 de rutine.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\")
<\/figure>\r\n\r\n\r\n\r\nFigure 1 Structure chimique de la rutine<\/h5>\r\n\r\n\r\n\r\nL'isoquercitrine, \u00e9galement connue sous le nom d'apocynum A, est un d\u00e9riv\u00e9 de la rutine d\u00e9riv\u00e9 du derhamnosyl. Sa formule mol\u00e9culaire est C21<\/sub>H20<\/sub>O12<\/sub>. La structure chimique de l'isoquercitrine est pr\u00e9sent\u00e9e \u00e0 la figure 2. L'isoquercitrine a un point de fusion d'environ 226 \u00b0C et se pr\u00e9sente sous la forme d'un cristal jaune \u00e0 temp\u00e9rature ambiante. Sa solubilit\u00e9 dans l'eau est faible, seulement 25,9 mg\/L \u00e0 temp\u00e9rature ambiante. Elle devient plus fonc\u00e9e apr\u00e8s avoir \u00e9t\u00e9 dissoute dans de l'eau alcaline. L'isoquercitrine est largement r\u00e9pandue dans les plantes, notamment Saururus chinensis, Houttuynia cordata, Rhododendron gold leaf, rhododendron, Ginkgo biloba, Morus mulberry et Elaeagnus seabuckthorn, etc. Cependant, la teneur naturelle des plantes en isoquercitrine est faible, seulement quelques dix milli\u00e8mes en moyenne, de sorte qu'elle est le plus souvent pr\u00e9par\u00e9e par des m\u00e9thodes synth\u00e9tiques. Des \u00e9tudes pharmacologiques modernes ont montr\u00e9 que l'activit\u00e9 pharmacologique de l'isoquercitrine est significativement plus \u00e9lev\u00e9e que celle de la rutine, et que sa valeur m\u00e9dicinale est plus \u00e9lev\u00e9e.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-2.png\")
<\/figure>\r\n\r\n\r\n\r\nFigure 2 Structure chimique de l'isoquercitrine<\/h5>\r\n\r\n\r\n\r\n2. Pr\u00e9paration de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nL'isoquercitrine a une faible teneur naturelle dans les plantes et elle est souvent pr\u00e9par\u00e9e par hydrolyse acide, hydrolyse \u00e0 haute pression et autres m\u00e9thodes dans l'industrie. Des \u00e9tudes ont utilis\u00e9 la chromatographie sur colonne pour s\u00e9parer le monom\u00e8re d'isoquercitrine des extraits de plantes. Par exemple, Shi Xin et al. ont utilis\u00e9 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour s\u00e9parer l'isoquercitrine avec une puret\u00e9 > 98,0% des mati\u00e8res m\u00e9dicinales de Yidianhong ; Yin Li a utilis\u00e9 la chromatographie sur colonne de r\u00e9sine macroporeuse combin\u00e9e \u00e0 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour obtenir de l'isoquercitrine \u00e0 partir de 580 mg de Huangdingju 9,3 mg d'isoquercitrine ont \u00e9t\u00e9 isol\u00e9s de l'extrait d'alcool, et sa puret\u00e9 \u00e9tait de 95,8%. Cependant, en raison de la faible teneur naturelle des plantes en isoquercitrine, cette m\u00e9thode a non seulement un faible rendement, mais aussi une charge de travail importante et une grande consommation de r\u00e9actifs, ce qui limite largement son application dans la pratique industrielle. Yu Ting et al. ont combin\u00e9 l'hydrolyse \u00e0 haute pression avec la technologie de s\u00e9paration chromatographique sur r\u00e9sine SG64 pour \u00e9tablir une m\u00e9thode de pr\u00e9paration rapide de l'isoquercitrine. Cependant, les conditions d'hydrolyse ne sont pas faciles \u00e0 contr\u00f4ler et le rendement de l'isoquercitrine est faible. Le produit contient une grande quantit\u00e9 de rutine et de querc\u00e9tine non hydrolys\u00e9es obtenues par hydrolyse ult\u00e9rieure, ce qui augmente la difficult\u00e9 de la s\u00e9paration ult\u00e9rieure.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-1.png\")
<\/figure>\r\n\r\n\r\n\r\nLa biotechnologie, telle que la transformation microbienne et la transformation catalys\u00e9e par une enzyme, est essentiellement une r\u00e9action m\u00e9tabolique qui utilise des enzymes libres ou des enzymes complexes pour modifier la structure de compos\u00e9s \u00e9trangers. Elle pr\u00e9sente les avantages suivants : conditions douces, forte s\u00e9lectivit\u00e9, peu de sous-produits, propret\u00e9, respect de l'environnement et faible co\u00fbt ; naturel ; les compos\u00e9s glycosidiques contiennent g\u00e9n\u00e9ralement plus de groupes glycosyles et sont tr\u00e8s polaires, de sorte qu'ils ne constituent pas la meilleure structure pour exercer leur activit\u00e9 pharmacologique. Leur conversion en glycosides faibles, en aglycones ou en d'autres produits permettra de mieux exercer leur efficacit\u00e9. Wang Yuanyuan et al. ont utilis\u00e9 Streptomyces griseus pour biotransformer la rutine et ont s\u00e9par\u00e9 6 produits de conversion, dont l'isoquercitrine, par chromatographie sur colonne de gel de silice. D'autres \u00e9tudes ont montr\u00e9 que les r\u00e9actions impliqu\u00e9es dans ce processus sont plus complexes, y compris la m\u00e9thylation et l'hydrolyse des glycosides, etc., ce qui indique que Streptomyces griseus a une faible sp\u00e9cificit\u00e9 pour la transformation de la rutine.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter.png\")
<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n![\"\"](\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/enter-2.png\")
<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nFigure 1 Structure chimique de la rutine<\/h5>\r\n\r\n\r\n\r\nL'isoquercitrine, \u00e9galement connue sous le nom d'apocynum A, est un d\u00e9riv\u00e9 de la rutine d\u00e9riv\u00e9 du derhamnosyl. Sa formule mol\u00e9culaire est C21<\/sub>H20<\/sub>O12<\/sub>. La structure chimique de l'isoquercitrine est pr\u00e9sent\u00e9e \u00e0 la figure 2. L'isoquercitrine a un point de fusion d'environ 226 \u00b0C et se pr\u00e9sente sous la forme d'un cristal jaune \u00e0 temp\u00e9rature ambiante. Sa solubilit\u00e9 dans l'eau est faible, seulement 25,9 mg\/L \u00e0 temp\u00e9rature ambiante. Elle devient plus fonc\u00e9e apr\u00e8s avoir \u00e9t\u00e9 dissoute dans de l'eau alcaline. L'isoquercitrine est largement r\u00e9pandue dans les plantes, notamment Saururus chinensis, Houttuynia cordata, Rhododendron gold leaf, rhododendron, Ginkgo biloba, Morus mulberry et Elaeagnus seabuckthorn, etc. Cependant, la teneur naturelle des plantes en isoquercitrine est faible, seulement quelques dix milli\u00e8mes en moyenne, de sorte qu'elle est le plus souvent pr\u00e9par\u00e9e par des m\u00e9thodes synth\u00e9tiques. Des \u00e9tudes pharmacologiques modernes ont montr\u00e9 que l'activit\u00e9 pharmacologique de l'isoquercitrine est significativement plus \u00e9lev\u00e9e que celle de la rutine, et que sa valeur m\u00e9dicinale est plus \u00e9lev\u00e9e.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nFigure 2 Structure chimique de l'isoquercitrine<\/h5>\r\n\r\n\r\n\r\n2. Pr\u00e9paration de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nL'isoquercitrine a une faible teneur naturelle dans les plantes et elle est souvent pr\u00e9par\u00e9e par hydrolyse acide, hydrolyse \u00e0 haute pression et autres m\u00e9thodes dans l'industrie. Des \u00e9tudes ont utilis\u00e9 la chromatographie sur colonne pour s\u00e9parer le monom\u00e8re d'isoquercitrine des extraits de plantes. Par exemple, Shi Xin et al. ont utilis\u00e9 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour s\u00e9parer l'isoquercitrine avec une puret\u00e9 > 98,0% des mati\u00e8res m\u00e9dicinales de Yidianhong ; Yin Li a utilis\u00e9 la chromatographie sur colonne de r\u00e9sine macroporeuse combin\u00e9e \u00e0 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour obtenir de l'isoquercitrine \u00e0 partir de 580 mg de Huangdingju 9,3 mg d'isoquercitrine ont \u00e9t\u00e9 isol\u00e9s de l'extrait d'alcool, et sa puret\u00e9 \u00e9tait de 95,8%. Cependant, en raison de la faible teneur naturelle des plantes en isoquercitrine, cette m\u00e9thode a non seulement un faible rendement, mais aussi une charge de travail importante et une grande consommation de r\u00e9actifs, ce qui limite largement son application dans la pratique industrielle. Yu Ting et al. ont combin\u00e9 l'hydrolyse \u00e0 haute pression avec la technologie de s\u00e9paration chromatographique sur r\u00e9sine SG64 pour \u00e9tablir une m\u00e9thode de pr\u00e9paration rapide de l'isoquercitrine. Cependant, les conditions d'hydrolyse ne sont pas faciles \u00e0 contr\u00f4ler et le rendement de l'isoquercitrine est faible. Le produit contient une grande quantit\u00e9 de rutine et de querc\u00e9tine non hydrolys\u00e9es obtenues par hydrolyse ult\u00e9rieure, ce qui augmente la difficult\u00e9 de la s\u00e9paration ult\u00e9rieure.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa biotechnologie, telle que la transformation microbienne et la transformation catalys\u00e9e par une enzyme, est essentiellement une r\u00e9action m\u00e9tabolique qui utilise des enzymes libres ou des enzymes complexes pour modifier la structure de compos\u00e9s \u00e9trangers. Elle pr\u00e9sente les avantages suivants : conditions douces, forte s\u00e9lectivit\u00e9, peu de sous-produits, propret\u00e9, respect de l'environnement et faible co\u00fbt ; naturel ; les compos\u00e9s glycosidiques contiennent g\u00e9n\u00e9ralement plus de groupes glycosyles et sont tr\u00e8s polaires, de sorte qu'ils ne constituent pas la meilleure structure pour exercer leur activit\u00e9 pharmacologique. Leur conversion en glycosides faibles, en aglycones ou en d'autres produits permettra de mieux exercer leur efficacit\u00e9. Wang Yuanyuan et al. ont utilis\u00e9 Streptomyces griseus pour biotransformer la rutine et ont s\u00e9par\u00e9 6 produits de conversion, dont l'isoquercitrine, par chromatographie sur colonne de gel de silice. D'autres \u00e9tudes ont montr\u00e9 que les r\u00e9actions impliqu\u00e9es dans ce processus sont plus complexes, y compris la m\u00e9thylation et l'hydrolyse des glycosides, etc., ce qui indique que Streptomyces griseus a une faible sp\u00e9cificit\u00e9 pour la transformation de la rutine.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nFigure 2 Structure chimique de l'isoquercitrine<\/h5>\r\n\r\n\r\n\r\n2. Pr\u00e9paration de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nL'isoquercitrine a une faible teneur naturelle dans les plantes et elle est souvent pr\u00e9par\u00e9e par hydrolyse acide, hydrolyse \u00e0 haute pression et autres m\u00e9thodes dans l'industrie. Des \u00e9tudes ont utilis\u00e9 la chromatographie sur colonne pour s\u00e9parer le monom\u00e8re d'isoquercitrine des extraits de plantes. Par exemple, Shi Xin et al. ont utilis\u00e9 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour s\u00e9parer l'isoquercitrine avec une puret\u00e9 > 98,0% des mati\u00e8res m\u00e9dicinales de Yidianhong ; Yin Li a utilis\u00e9 la chromatographie sur colonne de r\u00e9sine macroporeuse combin\u00e9e \u00e0 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour obtenir de l'isoquercitrine \u00e0 partir de 580 mg de Huangdingju 9,3 mg d'isoquercitrine ont \u00e9t\u00e9 isol\u00e9s de l'extrait d'alcool, et sa puret\u00e9 \u00e9tait de 95,8%. Cependant, en raison de la faible teneur naturelle des plantes en isoquercitrine, cette m\u00e9thode a non seulement un faible rendement, mais aussi une charge de travail importante et une grande consommation de r\u00e9actifs, ce qui limite largement son application dans la pratique industrielle. Yu Ting et al. ont combin\u00e9 l'hydrolyse \u00e0 haute pression avec la technologie de s\u00e9paration chromatographique sur r\u00e9sine SG64 pour \u00e9tablir une m\u00e9thode de pr\u00e9paration rapide de l'isoquercitrine. Cependant, les conditions d'hydrolyse ne sont pas faciles \u00e0 contr\u00f4ler et le rendement de l'isoquercitrine est faible. Le produit contient une grande quantit\u00e9 de rutine et de querc\u00e9tine non hydrolys\u00e9es obtenues par hydrolyse ult\u00e9rieure, ce qui augmente la difficult\u00e9 de la s\u00e9paration ult\u00e9rieure.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa biotechnologie, telle que la transformation microbienne et la transformation catalys\u00e9e par une enzyme, est essentiellement une r\u00e9action m\u00e9tabolique qui utilise des enzymes libres ou des enzymes complexes pour modifier la structure de compos\u00e9s \u00e9trangers. Elle pr\u00e9sente les avantages suivants : conditions douces, forte s\u00e9lectivit\u00e9, peu de sous-produits, propret\u00e9, respect de l'environnement et faible co\u00fbt ; naturel ; les compos\u00e9s glycosidiques contiennent g\u00e9n\u00e9ralement plus de groupes glycosyles et sont tr\u00e8s polaires, de sorte qu'ils ne constituent pas la meilleure structure pour exercer leur activit\u00e9 pharmacologique. Leur conversion en glycosides faibles, en aglycones ou en d'autres produits permettra de mieux exercer leur efficacit\u00e9. Wang Yuanyuan et al. ont utilis\u00e9 Streptomyces griseus pour biotransformer la rutine et ont s\u00e9par\u00e9 6 produits de conversion, dont l'isoquercitrine, par chromatographie sur colonne de gel de silice. D'autres \u00e9tudes ont montr\u00e9 que les r\u00e9actions impliqu\u00e9es dans ce processus sont plus complexes, y compris la m\u00e9thylation et l'hydrolyse des glycosides, etc., ce qui indique que Streptomyces griseus a une faible sp\u00e9cificit\u00e9 pour la transformation de la rutine.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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L'isoquercitrine a une faible teneur naturelle dans les plantes et elle est souvent pr\u00e9par\u00e9e par hydrolyse acide, hydrolyse \u00e0 haute pression et autres m\u00e9thodes dans l'industrie. Des \u00e9tudes ont utilis\u00e9 la chromatographie sur colonne pour s\u00e9parer le monom\u00e8re d'isoquercitrine des extraits de plantes. Par exemple, Shi Xin et al. ont utilis\u00e9 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour s\u00e9parer l'isoquercitrine avec une puret\u00e9 > 98,0% des mati\u00e8res m\u00e9dicinales de Yidianhong ; Yin Li a utilis\u00e9 la chromatographie sur colonne de r\u00e9sine macroporeuse combin\u00e9e \u00e0 la chromatographie liquide semi-pr\u00e9parative \u00e0 haute performance pour obtenir de l'isoquercitrine \u00e0 partir de 580 mg de Huangdingju 9,3 mg d'isoquercitrine ont \u00e9t\u00e9 isol\u00e9s de l'extrait d'alcool, et sa puret\u00e9 \u00e9tait de 95,8%. Cependant, en raison de la faible teneur naturelle des plantes en isoquercitrine, cette m\u00e9thode a non seulement un faible rendement, mais aussi une charge de travail importante et une grande consommation de r\u00e9actifs, ce qui limite largement son application dans la pratique industrielle. Yu Ting et al. ont combin\u00e9 l'hydrolyse \u00e0 haute pression avec la technologie de s\u00e9paration chromatographique sur r\u00e9sine SG64 pour \u00e9tablir une m\u00e9thode de pr\u00e9paration rapide de l'isoquercitrine. Cependant, les conditions d'hydrolyse ne sont pas faciles \u00e0 contr\u00f4ler et le rendement de l'isoquercitrine est faible. Le produit contient une grande quantit\u00e9 de rutine et de querc\u00e9tine non hydrolys\u00e9es obtenues par hydrolyse ult\u00e9rieure, ce qui augmente la difficult\u00e9 de la s\u00e9paration ult\u00e9rieure.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa biotechnologie, telle que la transformation microbienne et la transformation catalys\u00e9e par une enzyme, est essentiellement une r\u00e9action m\u00e9tabolique qui utilise des enzymes libres ou des enzymes complexes pour modifier la structure de compos\u00e9s \u00e9trangers. Elle pr\u00e9sente les avantages suivants : conditions douces, forte s\u00e9lectivit\u00e9, peu de sous-produits, propret\u00e9, respect de l'environnement et faible co\u00fbt ; naturel ; les compos\u00e9s glycosidiques contiennent g\u00e9n\u00e9ralement plus de groupes glycosyles et sont tr\u00e8s polaires, de sorte qu'ils ne constituent pas la meilleure structure pour exercer leur activit\u00e9 pharmacologique. Leur conversion en glycosides faibles, en aglycones ou en d'autres produits permettra de mieux exercer leur efficacit\u00e9. Wang Yuanyuan et al. ont utilis\u00e9 Streptomyces griseus pour biotransformer la rutine et ont s\u00e9par\u00e9 6 produits de conversion, dont l'isoquercitrine, par chromatographie sur colonne de gel de silice. D'autres \u00e9tudes ont montr\u00e9 que les r\u00e9actions impliqu\u00e9es dans ce processus sont plus complexes, y compris la m\u00e9thylation et l'hydrolyse des glycosides, etc., ce qui indique que Streptomyces griseus a une faible sp\u00e9cificit\u00e9 pour la transformation de la rutine.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nLa biotechnologie, telle que la transformation microbienne et la transformation catalys\u00e9e par une enzyme, est essentiellement une r\u00e9action m\u00e9tabolique qui utilise des enzymes libres ou des enzymes complexes pour modifier la structure de compos\u00e9s \u00e9trangers. Elle pr\u00e9sente les avantages suivants : conditions douces, forte s\u00e9lectivit\u00e9, peu de sous-produits, propret\u00e9, respect de l'environnement et faible co\u00fbt ; naturel ; les compos\u00e9s glycosidiques contiennent g\u00e9n\u00e9ralement plus de groupes glycosyles et sont tr\u00e8s polaires, de sorte qu'ils ne constituent pas la meilleure structure pour exercer leur activit\u00e9 pharmacologique. Leur conversion en glycosides faibles, en aglycones ou en d'autres produits permettra de mieux exercer leur efficacit\u00e9. Wang Yuanyuan et al. ont utilis\u00e9 Streptomyces griseus pour biotransformer la rutine et ont s\u00e9par\u00e9 6 produits de conversion, dont l'isoquercitrine, par chromatographie sur colonne de gel de silice. D'autres \u00e9tudes ont montr\u00e9 que les r\u00e9actions impliqu\u00e9es dans ce processus sont plus complexes, y compris la m\u00e9thylation et l'hydrolyse des glycosides, etc., ce qui indique que Streptomyces griseus a une faible sp\u00e9cificit\u00e9 pour la transformation de la rutine.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nLa m\u00e9thode d'hydrolyse enzymatique pr\u00e9sente les avantages de conditions de r\u00e9action douces, d'une forte sp\u00e9cificit\u00e9 et d'un contr\u00f4le facile de la r\u00e9action, et peut surmonter les insuffisances de la m\u00e9thode susmentionn\u00e9e pour pr\u00e9parer l'isoquercitrine. Par exemple, Wu Di et al. ont utilis\u00e9 l'\u03b1-L-rhamnosidase produite par des micro-organismes pour transformer la rutine ; les r\u00e9sultats ont montr\u00e9 que le rendement de l'isoquercitrine \u00e9tait de 49,4%, et que sa puret\u00e9 pouvait atteindre 98,3% apr\u00e8s purification par chromatographie sur colonne de gel de silice. Sun Guoxia et al. ont utilis\u00e9 l'hesp\u00e9ridinase pour hydrolyser la rutine et pr\u00e9parer l'isoquercitrine, et ont utilis\u00e9 des liquides ioniques pour augmenter le rendement de l'isoquercitrine. Le taux de conversion du produit final a atteint 99,27 \u00b1 0,55%.<\/h5>\r\n\r\n\r\n\r\n3. Introduction aux activit\u00e9s pharmacologiques de la rutine et de l'isoquercitrine<\/h3>\r\n\r\n\r\n\r\nLa rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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La rutine est un composant important de la m\u00e9decine traditionnelle chinoise (carthame) et d'autres m\u00e9dicaments qui favorisent la circulation sanguine et \u00e9liminent la stase sanguine. Elle a certains effets sur les maladies cardiovasculaires et c\u00e9r\u00e9brovasculaires telles que la thrombose c\u00e9r\u00e9brale et l'angine de poitrine. Jin Ming et al. ont d\u00e9couvert qu'une certaine concentration de rutine peut antagoniser la liaison sp\u00e9cifique du facteur d'activation des plaquettes et des r\u00e9cepteurs plaquettaires du lapin, inhibant ainsi l'adh\u00e9sion plaquettaire m\u00e9di\u00e9e par le facteur d'activation et l'augmentation du Ca2+<\/sup>\u00a0dans les plaquettes.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nGuardia et al. ont \u00e9tudi\u00e9 trois flavono\u00efdes, l'hesp\u00e9ridine, la querc\u00e9tine et la rutine, et les effets anti-inflammatoires de ces trois flavono\u00efdes sur des rats. Tout d'abord, un mod\u00e8le d'inflammation aigu\u00eb et chronique a \u00e9t\u00e9 construit chez le rat. Apr\u00e8s administration intrap\u00e9riton\u00e9ale d'une dose de 80 mg\/kg\/j, les trois flavono\u00efdes peuvent inhiber les phases aigu\u00ebs et chroniques du mod\u00e8le d'inflammation exp\u00e9rimental ; parmi eux, la rutine a l'effet le plus fort sur l'inflammation chronique. Yoo et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la rutine sur la r\u00e9ponse pro-inflammatoire des cellules endoth\u00e9liales de la veine ombilicale humaine (HUVEC) induite par la prot\u00e9ine 1 du groupe de haute mobilit\u00e9 (HMGB1) et les voies de signalisation associ\u00e9es. Les r\u00e9sultats montrent que la rutine peut inhiber la lib\u00e9ration de HMGB1 et r\u00e9duire la migration des leucocytes de souris. D'autres \u00e9tudes ont montr\u00e9 que la rutine peut \u00e9galement inhiber la production du facteur de n\u00e9crose tumorale alpha et de l'interleukine 6 induite par HMGB1, ce qui prouve que la rutine peut traiter diverses maladies vasculaires graves en inhibant la voie de signalisation HMGB1.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nYang et al. ont mesur\u00e9 l'activit\u00e9 antioxydante de la rutine et l'ont compar\u00e9e \u00e0 celle de l'antioxydant standard, le butylhydroxytolu\u00e8ne (BHT), et \u00e0 celle de l'acide ascorbique (Vc). Les r\u00e9sultats montrent que la rutine a une forte capacit\u00e9 \u00e0 pi\u00e9ger les radicaux libres DPPH. \u00c0 une concentration de 0,05 mg\/mL, les taux d'inhibition du Vc, du BHT et de la rutine peuvent atteindre respectivement 92,8%, 58,8% et 90,4% ; en outre, la rutine a un effet important sur les lipides. La peroxydation qualitative a \u00e9galement un effet inhibiteur significatif.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nAlonso-Castro et al. ont utilis\u00e9 la m\u00e9thode MTT pour d\u00e9tecter l'effet cytotoxique de la rutine sur les cellules canc\u00e9reuses humaines et les lign\u00e9es cellulaires non tumorig\u00e8nes. Diff\u00e9rentes doses de rutine ont \u00e9t\u00e9 inject\u00e9es par voie intrap\u00e9riton\u00e9ale \u00e0 des souris nu\/nu atteintes d'un carcinome du c\u00f4lon SW480 pendant 32 jours ; les taux s\u00e9riques de facteur de croissance endoth\u00e9liale vasculaire (VEGF), le temps de survie et les effets toxicologiques sur le poids corporel et le poids des organes ont \u00e9t\u00e9 analys\u00e9s. Les r\u00e9sultats montrent que la rutine a l'effet cytotoxique le plus \u00e9lev\u00e9 sur les cellules SW480 (IC50 = 125 \u03bcM), et n'a pas d'effet toxique sur les autres organes des souris ; par rapport aux souris non trait\u00e9es, la dur\u00e9e de survie moyenne est prolong\u00e9e de 50 jours, et le taux s\u00e9rique de VEGF A diminu\u00e9 de 55%. Saleh et al. ont compar\u00e9 les effets anticanc\u00e9reux de la rutine et de l'orlistat sur deux mod\u00e8les de cancer du sein (in vivo EAC et in vitro MCF7) et sur des lign\u00e9es cellulaires de cancer du pancr\u00e9as (PANC-1). Le volume tumoral, le taux de CEA (antig\u00e8ne carcino-embryonnaire), la teneur en cholest\u00e9rol, l'antig\u00e8ne FAS, l'effet antioxydant et l'examen histopathologique ont montr\u00e9 que la rutine et l'orlistat avaient tous deux une activit\u00e9 anticanc\u00e9reuse dans l'organisme. En outre, ils sont tous deux cytotoxiques pour les lign\u00e9es cellulaires MCF-7 et PANC-1 en favorisant l'apoptose.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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<\/figure>\r\n\r\n\r\n\r\nDes \u00e9tudes pharmacologiques modernes ont montr\u00e9 que les activit\u00e9s pharmacologiques de l'isoquercitrine en mati\u00e8re d'anti-oxydation, d'anti-tumorale et d'autres aspects sont significativement plus \u00e9lev\u00e9es que celles de la rutine. Jung et al. ont isol\u00e9 sept compos\u00e9s tels que l'isoquercitrine \u00e0 partir de Platycladus orientalis et ont test\u00e9 leur activit\u00e9 antioxydante. Les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet sur la lign\u00e9e de cellules ganglionnaires r\u00e9tiniennes RGC-5 induite par le peroxyde d'hydrog\u00e8ne (H2<\/sub>O2<\/sub>). L'effet inhibiteur de la mort cellulaire est le plus fort. En m\u00eame temps, l'isoquercitrine est tol\u00e9r\u00e9e par voie orale et peut donc \u00eatre utilis\u00e9e pour traiter des maladies telles que le glaucome. Rogerio et al. ont \u00e9tudi\u00e9 les effets anti-inflammatoires de la querc\u00e9tine et de l'isoquercitrine sur des mod\u00e8les murins d'asthme ; les r\u00e9sultats ont montr\u00e9 que ces deux flavono\u00efdes sont des inhibiteurs efficaces de l'inflammation \u00e9osinophile et qu'ils ont un certain potentiel pour le traitement des maladies allergiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nHuang et al. ont \u00e9tudi\u00e9 le m\u00e9canisme de l'effet de l'isoquercitrine sur le cancer du foie. Lors d'exp\u00e9riences in vitro, il a \u00e9t\u00e9 constat\u00e9 que l'isoquercitrine peut inhiber la prolif\u00e9ration des cellules canc\u00e9reuses tout en favorisant leur apoptose et, en m\u00eame temps, r\u00e9duire le niveau d'expression de la PKC dans les cellules canc\u00e9reuses du foie humain ; lors d'exp\u00e9riences in vivo, l'isoquercitrine peut \u00e9galement provoquer des tumeurs transplant\u00e9es chez des souris nude. Le taux de croissance des cellules est consid\u00e9rablement r\u00e9duit. Il est confirm\u00e9 que l'isoquercitrine peut inhiber de mani\u00e8re significative l'apparition et le d\u00e9veloppement du cancer du foie, et que son m\u00e9canisme mol\u00e9culaire peut \u00eatre li\u00e9 aux voies de signalisation PKC et MAPK.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nJi Lili a compar\u00e9 l'activit\u00e9 hypoglyc\u00e9mique in vitro de l'isoquercitrine et des flavono\u00efdes totaux des feuilles de Moringa oleifera. Les r\u00e9sultats montrent que les deux peuvent augmenter de mani\u00e8re significative la consommation de glucose par les cellules HepG2, et que l'effet hypoglyc\u00e9mique de l'isoquercitrine est significativement plus fort que celui des flavono\u00efdes totaux ; d'autres \u00e9tudes ont montr\u00e9 que son m\u00e9canisme hypoglyc\u00e9mique est principalement renforc\u00e9 par l'inhibition de l'activit\u00e9 de la DPP-4 et de la s\u00e9cr\u00e9tion d'insuline, ainsi que par la r\u00e9gulation \u00e0 la hausse de l'expression de l'InsR, de la PKA et de la PKC\u03b1, renfor\u00e7ant ainsi l'effet de l'insuline et favorisant la prolif\u00e9ration des cellules du foie et des \u00eelots pancr\u00e9atiques.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nYun et al. ont examin\u00e9 l'activit\u00e9 antifongique de l'isoquercitrine et son m\u00e9canisme d'action ; les r\u00e9sultats ont montr\u00e9 que l'isoquercitrine a un effet important sur l'antibiogramme des champignons pathog\u00e8nes et qu'aucune h\u00e9molyse n'a \u00e9t\u00e9 constat\u00e9e. En outre, le candida albicans a \u00e9galement \u00e9t\u00e9 test\u00e9 pour la lib\u00e9ration d'iodure de malonyle et de potassium, ce qui confirme que l'isoquercitrine peut interf\u00e9rer avec la membrane cellulaire et augmenter sa perm\u00e9abilit\u00e9 pour favoriser les dommages membranaires, exer\u00e7ant ainsi une activit\u00e9 antibact\u00e9rienne. Kim et al. ont d\u00e9couvert que l'isoquercitrine peut inhiber la r\u00e9plication des virus de la grippe A et B et que, lorsqu'elle est utilis\u00e9e conjointement avec l'amantadine et l'oseltamivir, elle peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants, ce qui indique que l'isoquercitrine peut inhiber efficacement l'\u00e9mergence de virus r\u00e9sistants. L'isoquercitrine pr\u00e9sente un certain potentiel d'application pour le traitement de la grippe virale.<\/h5>\r\n\r\n\r\n\r\n<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
\n- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n\n- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\nSi vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n\r\n\r\n\r\nCompos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\nPullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\nXylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\nCellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\nNaringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n\u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\nGlucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\nalpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\nPectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\nPeroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\nLipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\nCatalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\nTANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\nElastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\nUr\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\nDEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\nL-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\nD\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\nCholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":"1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical<\/title>\n<meta name=\"description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation and pharmacological activity of rutin and isoquercitrin - Longchang Chemical\" \/>\n<meta property=\"og:description\" content=\"We hope our products are used worldwide to enable science.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangchemical.com\/fr\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\" \/>\n<meta property=\"og:site_name\" content=\"Longchang Chemical\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T14:43:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-28T10:41:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"396\" \/>\n\t<meta property=\"og:image:height\" content=\"230\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Longchang Chemical\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"author\":{\"name\":\"Longchang Chemical\",\"@id\":\"https:\/\/longchangchemical.com\/#\/schema\/person\/ecb1ad846136c6f1ca534b62978c6a8e\"},\"headline\":\"Preparation and pharmacological activity of rutin and isoquercitrin\",\"datePublished\":\"2021-03-24T14:43:25+00:00\",\"dateModified\":\"2026-04-28T10:41:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\"},\"wordCount\":2138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/longchangchemical.com\/#organization\"},\"image\":{\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangchemical.com\/wp-content\/uploads\/2021\/03\/image-1.png\",\"articleSection\":[\"Enzyme News\"],\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"url\":\"https:\/\/longchangchemical.com\/preparation-and-pharmacological-activity-of-rutin-and-isoquercitrin\/\",\"name\":\"Preparation and pharmacological activity of rutin and isoquercitrin - 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<\/figure>\r\n\r\n\r\n\r\nOutre les effets susmentionn\u00e9s, l'isoquercitrine a \u00e9galement des activit\u00e9s physiologiques telles que la lutte contre l'ost\u00e9oporose, la r\u00e9duction de la pression art\u00e9rielle et des lipides sanguins, la neuroprotection et la lutte contre la d\u00e9pression. L'application de l'\u03b1-L-rhamnosidase dans la biotransformation de la rutine sera pr\u00e9sent\u00e9e plus loin.<\/h5>\r\n\r\n\r\n\n\n\nHow buyers usually evaluate UV monomers and resin systems<\/h2>\n
Most successful UV formulations are built by choosing the backbone first and then tuning the reactive monomer package around the substrate, cure method, and end-use stress. That usually produces a more stable result than choosing materials by viscosity or price alone.<\/p>\n
- \n
- Start from the final property target:<\/strong> hardness, flexibility, adhesion, and shrinkage rarely point to exactly the same raw-material package.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n
- Use viscosity as a tool, not the only decision rule:<\/strong> the easiest-processing material is not always the one that performs best after cure.<\/li>\n
- Check the real substrate:<\/strong> plastic, metal, label film, gel systems, and coatings can reward very different polarity and cure-density balances.<\/li>\n<\/ul>\n
Recommended product references<\/h3>\n
- \n
- CHLUMIAO 1010<\/a>:<\/strong> A widely used primary antioxidant benchmark for long-term thermal stability.<\/li>\n
- CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Longzyme Lipase<\/a>:<\/strong> A direct product reference for lipase-related food, cleaning, or bioprocess discussions.<\/li>\n
- Longzyme Beta-Amylase<\/a>:<\/strong> A practical enzyme reference when starch conversion and food-processing activity are under review.<\/li>\n<\/ul>\n
FAQ for buyers and formulators<\/h3>\n
Can one UV monomer or resin solve every formulation problem?<\/strong>
Usually no. Commercially strong formulas depend on how several components work together to balance cure, adhesion, flow, and durability.<\/p>\nWhy should monomers be screened together with oligomers?<\/strong>
Because monomers can change viscosity, cure rate, shrinkage, and substrate behavior enough to alter the final ranking of the same backbone resin.<\/p>\n\n\nContactez-nous d\u00e8s maintenant !<\/b><\/strong><\/h2>\r\n
Si vous avez besoin de Price, veuillez indiquer vos coordonn\u00e9es dans le formulaire ci-dessous. Nous vous contacterons g\u00e9n\u00e9ralement dans les 24 heures. Vous pouvez \u00e9galement m'envoyer un courriel\u00a0info@longchangchemical.com<\/a><\/span>\u00a0pendant les heures de travail ( 8:30 am to 6:00 pm UTC+8 Mon.~Sat. ) ou utilisez le chat en direct du site web pour obtenir une r\u00e9ponse rapide.<\/b><\/strong><\/h4>\r\n
\r\n\r\n
\r\n Compos\u00e9 Glucoamylase<\/span><\/a><\/td>\r\n 9032-08-0<\/td>\r\n<\/tr>\r\n \r\n Pullulanase<\/span><\/a><\/td>\r\n 9075-68-7<\/td>\r\n<\/tr>\r\n \r\n Xylanase<\/span><\/a><\/td>\r\n 37278-89-0<\/td>\r\n<\/tr>\r\n \r\n Cellulase<\/span><\/a><\/td>\r\n 9012-54-8<\/td>\r\n<\/tr>\r\n \r\n Naringinase<\/span><\/a><\/td>\r\n 9068-31-9<\/td>\r\n<\/tr>\r\n \r\n \u03b2-Amylase<\/span><\/a><\/td>\r\n 9000-91-3<\/td>\r\n<\/tr>\r\n \r\n Glucose oxydase<\/span><\/a><\/td>\r\n 9001-37-0<\/td>\r\n<\/tr>\r\n \r\n alpha-amylase<\/td>\r\n 9000-90-2<\/td>\r\n<\/tr>\r\n \r\n Pectinase<\/span><\/a><\/td>\r\n 9032-75-1<\/td>\r\n<\/tr>\r\n \r\n Peroxydase<\/td>\r\n 9003-99-0<\/td>\r\n<\/tr>\r\n \r\n Lipase<\/span><\/a><\/td>\r\n 9001-62-1<\/td>\r\n<\/tr>\r\n \r\n Catalase<\/span><\/a><\/td>\r\n 9001-05-2<\/td>\r\n<\/tr>\r\n \r\n TANNASE<\/span><\/a><\/td>\r\n 9025-71-2<\/td>\r\n<\/tr>\r\n \r\n Elastase<\/span><\/a><\/td>\r\n 39445-21-1<\/td>\r\n<\/tr>\r\n \r\n Ur\u00e9ase<\/span><\/a><\/td>\r\n 9002-13-5<\/td>\r\n<\/tr>\r\n \r\n DEXTRANASE<\/span><\/a><\/td>\r\n 9025-70-1<\/td>\r\n<\/tr>\r\n \r\n L-Lactique d\u00e9shydrog\u00e9nase<\/span><\/a><\/td>\r\n 9001-60-9<\/td>\r\n<\/tr>\r\n \r\n D\u00e9shydrog\u00e9nase malate<\/span><\/a><\/td>\r\n 9001-64-3<\/td>\r\n<\/tr>\r\n \r\n Cholest\u00e9rol oxydase<\/span><\/a><\/td>\r\n 9028-76-6<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","protected":false},"excerpt":{"rendered":" 1. Introduction to Rutin and Isoquercitrin Rutin, also known as vitamin P, has a molecular formula of C27H30O16. The chemical structure of rutin is shown in Figure 1. It is<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[108],"tags":[],"class_list":["post-4452","post","type-post","status-publish","format-standard","hentry","category-enzyme-news"],"yoast_head":"\n
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CHLUMIAO 168<\/a>:<\/strong> A practical process-stability reference when hydroperoxide control matters.<\/li>\n
- Screen the reactive package as a whole:<\/strong> oligomer, monomer, and photoinitiator choices interact strongly in UV systems.<\/li>\n